INT80635

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Context Info
Confidence 0.04
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1) transmembrane transport (RYR1) cytoplasm (RYR1)
Anatomy Link Frequency
reticulum 2
RYR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 2 54.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the pronounced myotoxicity of bupivacaine may be the result of this specific effect on Ca2+ release channel-ryanodine receptor superimposed on a nonspecific action on lipid bilayers to increase the Ca2+ permeability of sarcoplasmic reticulum membranes, an effect shared by all local anesthetics.
Regulation (effect) of Localization (release) of channel-ryanodine receptor in reticulum
1) Confidence 0.04 Published 1999 Journal Anesthesiology Section Body Doc Link 10078686 Disease Relevance 0.10 Pain Relevance 0

General Comments

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