INT80636

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1) transmembrane transport (RYR1) cytoplasm (RYR1)
Anatomy Link Frequency
skeletal muscle 2
RYR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 89.24 High High
Spinal cord 1 84.00 Quite High
Central nervous system 1 54.12 Quite High
depression 2 14.68 Low Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 9 99.52 Very High Very High Very High
Injury 8 94.12 High High
Pain 3 89.24 High High
Mental Disorders 20 73.08 Quite High
Toxicity 2 64.12 Quite High
Anxiety 1 39.64 Quite Low
Hypesthesia 2 31.72 Quite Low
Sleep Disorders 1 29.80 Quite Low
Traumatic Stress Disorders 1 16.08 Low Low
Depression 2 14.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these studies suggest that caffeine can enhance contractile force during submaximal contractions by potentiating calcium release from the ryanodine receptor, not by altering sarcoplasmic excitability.
Neg (not) Positive_regulation (enhance) of Localization (release) of ryanodine receptor
1) Confidence 0.47 Published 2008 Journal Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme Section Abstract Doc Link 19088790 Disease Relevance 0.16 Pain Relevance 0.29
They showed that (subclinical) PTSD was clearly related to increased use of MHS.
Positive_regulation (increased) of Localization (use) of MHS associated with post-traumatic stress disorder
2) Confidence 0.44 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.50 Pain Relevance 0
CONCLUSIONS: Bupivacaine's ability to enhance Ca2+ release channel-ryanodine receptor activity of skeletal muscle sarcoplasmic reticulum most likely contributes to the myotoxicity of this local anesthetic.
Spec (likely) Positive_regulation (enhance) of Localization (release) of channel-ryanodine receptor in skeletal muscle
3) Confidence 0.08 Published 1999 Journal Anesthesiology Section Body Doc Link 10078686 Disease Relevance 0.12 Pain Relevance 0

General Comments

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