INT8065

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2011
Negated 7
Speculated 0
Reported most in Body
Documents 54
Total Number 55
Disease Relevance 20.54
Pain Relevance 10.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
AT-1 4
plasma 3
blood 3
blood cells 2
cleavage 1
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 12 100.00 Very High Very High Very High
Somatostatin 8 100.00 Very High Very High Very High
Angina 35 99.84 Very High Very High Very High
bradykinin 81 99.76 Very High Very High Very High
cytokine 24 99.76 Very High Very High Very High
Inflammation 127 99.64 Very High Very High Very High
antagonist 165 99.44 Very High Very High Very High
Enkephalin 14 99.36 Very High Very High Very High
Neuropeptide 44 98.80 Very High Very High Very High
Opioid 17 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Angina 1 99.84 Very High Very High Very High
Hypertension 549 99.64 Very High Very High Very High
INFLAMMATION 147 99.64 Very High Very High Very High
Diabetes Mellitus 486 99.54 Very High Very High Very High
Stress 47 98.96 Very High Very High Very High
Bladder Cancer 2 98.80 Very High Very High Very High
Myocardial Infarction 100 98.52 Very High Very High Very High
Syndrome 67 98.36 Very High Very High Very High
Pre-eclampsia 125 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
125I-Angiotensin II binding to human blood cells.
Angiotensin II Binding (binding) of in blood cells
1) Confidence 0.48 Published 1985 Journal J. Hypertens. Section Title Doc Link 2991370 Disease Relevance 0 Pain Relevance 0.08
This occurs in part as the result of interactions between vasoconstrictors, e.g., angiotensin II (AII), and the vasodilatory prostaglandins E2 or I2.
angiotensin II Binding (interactions) of
2) Confidence 0.43 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092664 Disease Relevance 0.13 Pain Relevance 0.13
The binding of 125I-angiotensin II to human blood cells was investigated.
angiotensin II Binding (binding) of in blood cells
3) Confidence 0.42 Published 1985 Journal J. Hypertens. Section Abstract Doc Link 2991370 Disease Relevance 0 Pain Relevance 0
Specific binding of 125I-angiotensin II was saturable.
angiotensin II Binding (binding) of
4) Confidence 0.42 Published 1985 Journal J. Hypertens. Section Abstract Doc Link 2991370 Disease Relevance 0 Pain Relevance 0.10
Unrelated peptides, e.g. bradykinin, vasopressin and enkephalin, did not displace specifically bound angiotensin II.
angiotensin II Binding (bound) of associated with enkephalin and bradykinin
5) Confidence 0.37 Published 1985 Journal J. Hypertens. Section Abstract Doc Link 2991370 Disease Relevance 0 Pain Relevance 0.15
Angiotensin II/III (AII/III), estradiol (E2) and progesterone concentrations increase with the size of the follicles.
Angiotensin II Binding (increase) of in follicles
6) Confidence 0.36 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2459891 Disease Relevance 0 Pain Relevance 0.40
Angiotensin II (AngII), the biologically active peptide of the renin-angiotensin system (RAS), is also recognized as a potent mitogen that participates in various pathological situations involving tissue remodeling.
angiotensin Binding (recognized) of
7) Confidence 0.36 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.97 Pain Relevance 0.05
Renin is the rate-limiting step of the RAAS and has unique specificity for its substrate, angiotensinogen.
angiotensin Binding (specificity) of
8) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.15 Pain Relevance 0.16
The rate of generation of angiotensin in ex-vivo plasma, or plasma renin activity (PRA), was assayed using a commercial radioimmune assay (RIA) kit (DiaSorin, Stillwater, MN, USA).
angiotensin Binding (generation) of in plasma
9) Confidence 0.36 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.13 Pain Relevance 0.07
The present study was designed to identify an interaction between the renin-angiotensin system and noradrenergic transmission in the human heart.
angiotensin Binding (interaction) of in heart
10) Confidence 0.36 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9381945 Disease Relevance 0.15 Pain Relevance 0.13
The renin-angiotensin system (RAS) is recognized as an important contributor to hypertension [22], and the majority of research concerned with this system has focused on the synthesis of AngII and its interaction with angiotensin receptors [23].
angiotensin Binding (interaction) of associated with hypertension
11) Confidence 0.36 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.57 Pain Relevance 0.03
The rat and human renin-angiotensin systems do not interact, so the hypertension and vasculopathy exhibited by these rats is the result of the overexpression of the human renin-angiotensin system.
angiotensin Neg (not) Binding (interact) of associated with hypertension
12) Confidence 0.35 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.75 Pain Relevance 0.16
The renin-angiotensin system (RAS) is recognized as an important contributor to hypertension [22], and the majority of research concerned with this system has focused on the synthesis of AngII and its interaction with angiotensin receptors [23].
angiotensin Binding (recognized) of associated with hypertension
13) Confidence 0.35 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.57 Pain Relevance 0.03
Thus our study shows specific binding of 125I-angiotensin II to human platelets.
angiotensin II Binding (binding) of in platelets
14) Confidence 0.32 Published 1985 Journal J. Hypertens. Section Abstract Doc Link 2991370 Disease Relevance 0 Pain Relevance 0.12
Other peptide activated GPCRs implicated in inflammation, like those that bind angiotensin II, N-formyl peptides, galanin, neuropeptide Y, opioids and oxytocin, are only briefly discussed because there is either less direct association with inflammation or few/no nonpeptidic antiinflammatory ligands known.
angiotensin II Binding (bind) of associated with inflammation, neuropeptide and opioid
15) Confidence 0.26 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16378503 Disease Relevance 1.00 Pain Relevance 0.52
We found an association between the A-20C polymorphism and increased risk of renal function decline and no association with the other angiotensinogen polymorphism in our population.
angiotensinogen Neg (no) Binding (association) of
16) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.88 Pain Relevance 0
Moreover, our data obtained in humans appear to confirm the co-regulatory interaction of COX-2 and angiotensin II in the control of renin release, as suggested by animal studies.


angiotensin II Binding (interaction) of
17) Confidence 0.24 Published 2001 Journal Swiss Med Wkly Section Body Doc Link 11345810 Disease Relevance 0 Pain Relevance 0
This plasma precursor is angiotensinogen and two forms of angiotensin, angiotensin I and II, were recognized in the mid 1950s.
angiotensin I Binding (recognized) of in plasma
18) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0 Pain Relevance 0
Pharmacological agents such as ACE inhibitors, that actively prevent the formation of angiotensin II, may therefore have a beneficial effect in terms of end-organ protection beyond their activity on BP.
angiotensin II Neg (prevent) Binding (formation) of
19) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.62 Pain Relevance 0
This plasma precursor is angiotensinogen and two forms of angiotensin, angiotensin I and II, were recognized in the mid 1950s.
angiotensin Binding (recognized) of in plasma
20) Confidence 0.22 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0 Pain Relevance 0

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