INT80656

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Context Info
Confidence 0.26
First Reported 1999
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.89
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SLC17A5) plasma membrane (SLC17A5) transmembrane transport (SLC17A5)
Anatomy Link Frequency
liver 3
plasma 2
blood 1
SLC17A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 295 99.64 Very High Very High Very High
methotrexate 4 99.46 Very High Very High Very High
withdrawal 10 99.12 Very High Very High Very High
cINOD 23 99.02 Very High Very High Very High
imagery 4 93.56 High High
alcohol 94 89.08 High High
abdominal pain 12 89.00 High High
Bile 5 88.24 High High
Glutamate 2 80.92 Quite High
corticosteroid 1 73.32 Quite High
Disease Link Frequency Relevance Heat
Injury 65 99.48 Very High Very High Very High
Hyperlipidemia 10 99.00 Very High Very High Very High
Blister 1 98.92 Very High Very High Very High
Hepatotoxicity 21 98.32 Very High Very High Very High
Diabetes Mellitus 22 98.30 Very High Very High Very High
Necrosis 7 96.36 Very High Very High Very High
Cancer 13 96.20 Very High Very High Very High
Colon Cancer 2 95.56 Very High Very High Very High
Jaundice 4 93.52 High High
Urticaria 1 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary outcome was change in serum alpha-GST, a sensitive experimental biomarker of hepatocellular injury; secondary outcomes were changes in serum AST, ALT, INR, and study withdrawal for a doubling of aminotransferases to >120 IU/L.
Regulation (changes) of AST associated with injury and withdrawal
1) Confidence 0.26 Published 2008 Journal Clin Toxicol (Phila) Section Abstract Doc Link 18344107 Disease Relevance 0.48 Pain Relevance 0.60
Therapeutic acetaminophen dosing in a total of 132 subjects showed no effect on serum ALT, AST, bilirubin or INR.
Neg (no) Regulation (effect) of AST associated with paracetamol
2) Confidence 0.14 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.12 Pain Relevance 0.49
There was a significantly greater number of patients with abnormal AST and ALT values in the isoflurane group than in the sevoflurane group.
Regulation (values) of AST
3) Confidence 0.12 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10081544 Disease Relevance 0 Pain Relevance 0
In this study, we identified NSAID-activated gene (NAG-1) as a potential molecular target of AST.
Regulation (target) of AST associated with cinod
4) Confidence 0.10 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.35 Pain Relevance 0.17
Our results indicate that NAG-1 is a potential molecular target of AST in its antitumorigenic and proapoptotic actions, which would have additive effects when used along with PI3K-Akt inhibitors.
Regulation (target) of AST
5) Confidence 0.10 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.31 Pain Relevance 0.13
As the other liver markers such as AST and ALT were not impacted it is possible to suggest that hydrogen water did not have a negative effect on liver function.
Neg (not) Regulation (impacted) of AST in liver
6) Confidence 0.08 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.11 Pain Relevance 0.07
The purpose of this study was twofold: (1) to determine if a 3-day course of acetaminophen dose (4.0 g/day) affects the serum ALT, AST or INR, and (2) to determine if the plasma concentration of reduced glutathione is affected by this acetaminophen dosing regimen.


Regulation (affects) of AST in plasma associated with paracetamol
7) Confidence 0.06 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.24 Pain Relevance 0.65
Our study had 95% power to detect a 15 IU/L change in AST or ALT, a smaller change than is typically used by common definitions of liver injury [16].
Regulation (change) of AST in liver associated with injury
8) Confidence 0.05 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.83 Pain Relevance 0.69
No statistically significant changes were observed in serum urea, uric acid, creatinine, electrolytes, ALT, AST, total protein, bilirubin or glucose levels between the treatment groups and control groups.
Neg (No) Regulation (changes) of AST
9) Confidence 0.05 Published 1999 Journal Drug Metabol Drug Interact Section Abstract Doc Link 10707126 Disease Relevance 0.07 Pain Relevance 0.10
Thus, the changes in activity and concentration of marker enzymes like AcP, AlkP, ALT and AST in blood sera could reflect the state of hepatotoxicity (35).
Regulation (changes) of AST in blood associated with hepatotoxicity
10) Confidence 0.05 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 1.04 Pain Relevance 0.11
However, no significant change of the serum AST, ALP, creatinine and urea was observed in those rats after being administered with 14 days of fresh star fruit juice at different storage times as compared to the control rats [Table 2].
Neg (no) Regulation (change) of AST
11) Confidence 0.04 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900059 Disease Relevance 0.38 Pain Relevance 0
Transient rises of ALT occurred in three patients who also received methotrexate, but all had above normal values of GGT and/or AST, lactic dehydrogenase (LDH), and ALT at screening, but were below the levels stated in the exclusion criteria.
Regulation (values) of AST associated with methotrexate
12) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297576 Disease Relevance 0.41 Pain Relevance 0.05
Blood for standard liver tests (serum values of prothrombin time, albumin, total bilirubin, AST, ALT and alkaline phosphatase) was withdrawn immediately before performing the breath test.


Regulation (values) of AST in liver
13) Confidence 0.02 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2875214 Disease Relevance 0.92 Pain Relevance 0.08
AST and ALT values were slightly diminished (100 and 170 U/L respectively), and alkaline phosphatase and GGT had decreased to 428 U/L and 170 U/L, respectively (Table 1).
Regulation (values) of AST
14) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2978230 Disease Relevance 1.15 Pain Relevance 0.04
Pitavastatin 1 mg or 2 mg was administered for 8 weeks to 79 type 2 diabetic patients with hypercholesterolemia who had never been treated with statins, and the effects on the fasting plasma glucose, hemoglobin A1c (HbA1c), AST, ALT, ?
Regulation (effects) of AST in plasma associated with diabetes mellitus and hyperlipidemia
15) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.47 Pain Relevance 0

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