INT80671

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.23
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HK2) mitochondrion (HK2) small molecule metabolic process (HK2)
carbohydrate metabolic process (HK2) kinase activity (HK2) transmembrane transport (HK2)
Anatomy Link Frequency
skeletal muscle 2
HK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 98.94 Very High Very High Very High
COX2 2 98.62 Very High Very High Very High
Angina 4 66.72 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 184 99.40 Very High Very High Very High
Obesity 8 97.60 Very High Very High Very High
Reprotox - General 1 3 95.56 Very High Very High Very High
Cancer 3 90.20 High High
INFLAMMATION 2 88.36 High High
Insulin Resistance 28 82.00 Quite High
Diabetes Mellitus-type I 4 72.96 Quite High
Microvascular Angina 2 67.84 Quite High
Muscle Disease 2 57.52 Quite High
Cv Unclassified Under Development 35 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the review is to discuss our present knowledge of the activities and gene expression of hexokinase II (HKII), phosphofructokinase (PFK) and glycogen synthase (GS) in human skeletal muscle in states of altered insulin-stimulated glucose metabolism.
Gene_expression (expression) of HKII in skeletal muscle
1) Confidence 0.70 Published 1999 Journal Dan Med Bull Section Abstract Doc Link 10081651 Disease Relevance 0.57 Pain Relevance 0.07
The aim of the review is to discuss our present knowledge of the activities and gene expression of hexokinase II (HKII), phosphofructokinase (PFK) and glycogen synthase (GS) in human skeletal muscle in states of altered insulin-stimulated glucose metabolism.
Gene_expression (expression) of hexokinase II in skeletal muscle
2) Confidence 0.61 Published 1999 Journal Dan Med Bull Section Abstract Doc Link 10081651 Disease Relevance 0.57 Pain Relevance 0.07
Furthermore, it has been shown that HK2 expression is stimulated by insulin in healthy individuals but not in obese or type 2 diabetes patients [34].
Gene_expression (expression) of HK2 associated with diabetes mellitus and obesity
3) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.83 Pain Relevance 0
This can explain the decrease in expression of HK2 in the type 2 diabetics since subjects were submitted to a hyperinsulinemic clamp before samples were taken.
Gene_expression (expression) of HK2 associated with diabetes mellitus
4) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.84 Pain Relevance 0
The 10 most highly differentially expressed genes detected by GSEA were: C20orf20, QSOX1, HK2, EIF2AK2, LMNB1, TP53RK, LY9, CCDC107, PAQR8, and SLC37A4.
Gene_expression (expressed) of HK2
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836383 Disease Relevance 0 Pain Relevance 0
We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, hK2, and the FK506-binding protein 51 (FKBP51).
Gene_expression (expression) of hK2 associated with cinod and cox2
6) Confidence 0.00 Published 2003 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12917209 Disease Relevance 0.42 Pain Relevance 0.70

General Comments

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