INT80674

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 18.14
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
liver 6
germline 2
skeletal muscle 2
T cells 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 99.36 Very High Very High Very High
Inflammatory response 12 98.72 Very High Very High Very High
Inflammation 85 98.16 Very High Very High Very High
Kinase C 3 84.76 Quite High
Bile 12 84.08 Quite High
cva 20 72.36 Quite High
Angina 3 71.04 Quite High
cINOD 36 50.00 Quite Low
COX-2 inhibitor 14 50.00 Quite Low
withdrawal 1 43.04 Quite Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 724 100.00 Very High Very High Very High
Cancer 362 100.00 Very High Very High Very High
Hepatocellular Cancer 306 99.84 Very High Very High Very High
Liver Cancer 60 99.84 Very High Very High Very High
Pancreatitis 88 99.56 Very High Very High Very High
INFLAMMATION 106 98.36 Very High Very High Very High
Hepatitis Virus Infection 24 95.72 Very High Very High Very High
Pneumonia 48 95.28 Very High Very High Very High
Hypertension 5 93.24 High High
Metastasis 68 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Negative_regulation (reduced) of Gene_expression (expression) of APC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
1) Confidence 0.59 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.91 Pain Relevance 0
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Negative_regulation (reduced) of Gene_expression (expression) of APC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
2) Confidence 0.59 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.75 Pain Relevance 0
This finding reflects the overall reduced expression of the APC protein in patients with HCC.
Negative_regulation (reduced) of Gene_expression (expression) of APC associated with hepatocellular cancer and familial adenomatous polyposis
3) Confidence 0.59 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.01 Pain Relevance 0
The level of APC protein expression was significantly reduced in HCC samples compared to that of the corresponding non-tumor liver tissue (p<0.05).


Negative_regulation (reduced) of Gene_expression (expression) of APC in liver associated with cancer and hepatocellular cancer
4) Confidence 0.43 Published 2007 Journal J Cancer Res Clin Oncol Section Abstract Doc Link PMC2757596 Disease Relevance 1.06 Pain Relevance 0
Overall no significant difference among the two isoforms was observed

Immunohistochemical analysis of APC expression

Negative_regulation (analysis) of Gene_expression (expression) of APC associated with familial adenomatous polyposis
5) Confidence 0.43 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.87 Pain Relevance 0.04
A recent study showed that APC hypermethylation can disrupt the APC/?
Negative_regulation (disrupt) of Gene_expression (hypermethylation) of APC associated with familial adenomatous polyposis
6) Confidence 0.43 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.42 Pain Relevance 0
PC deficiency and decreased APC generation in severe AP probably contributed to a compromised anticoagulant and anti-inflammatory defence.
Negative_regulation (decreased) of Gene_expression (generation) of APC associated with inflammation and pancreatitis
7) Confidence 0.35 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1550818 Disease Relevance 0.67 Pain Relevance 0.10
PC deficiency and decreased APC generation in severe AP probably contributed to a compromised anticoagulant and anti-inflammatory defence.
Negative_regulation (deficiency) of Gene_expression (generation) of APC associated with inflammation and pancreatitis
8) Confidence 0.35 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1550818 Disease Relevance 0.72 Pain Relevance 0.10
The APC and pre-SAP studies
Negative_regulation (The) of Gene_expression (studies) of APC
9) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376081 Disease Relevance 0.80 Pain Relevance 0.09
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Negative_regulation (inactivation) of Gene_expression (existing) of APC associated with cancer
10) Confidence 0.28 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.35 Pain Relevance 0
Gan Yuebo et al. [59] first reported an APC germline mutation in Chinese FAP patients in 1994.
Negative_regulation (reported) of Gene_expression (mutation) of APC in germline associated with familial adenomatous polyposis
11) Confidence 0.26 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 2.04 Pain Relevance 0
The aim of the review is to discuss our present knowledge of the activities and gene expression of hexokinase II (HKII), phosphofructokinase (PFK) and glycogen synthase (GS) in human skeletal muscle in states of altered insulin-stimulated glucose metabolism.
Negative_regulation (discuss) of Gene_expression (expression) of GS in skeletal muscle
12) Confidence 0.25 Published 1999 Journal Dan Med Bull Section Abstract Doc Link 10081651 Disease Relevance 0.61 Pain Relevance 0.07
2 T cells prevented this response, which fully agrees with the observed inhibition of APC marker expression (Fig. 4).
Negative_regulation (inhibition) of Gene_expression (expression) of APC in T cells
13) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.14 Pain Relevance 0
Decreased expression of the adenomatous polyposis coli (Apc) gene and/or its homologs was also observed after exposure to PB and PTU.
Negative_regulation (Decreased) of Gene_expression (expression) of Apc associated with familial adenomatous polyposis
14) Confidence 0.04 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.26 Pain Relevance 0.12
was non detectable in CTR and APC groups.
Negative_regulation (detectable) of Gene_expression (groups) of APC
15) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1435891 Disease Relevance 1.37 Pain Relevance 0.17
In conclusion, preeclamptic women have more pronounced deficiencies of PC, PS, ATIII and more APC resistance compared to normal pregnant women.
Negative_regulation (deficiencies) of Gene_expression (resistance) of APC
16) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.17 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox