INT8068

Context Info Confidence 0.54 First Reported 1992 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 29 Total Number 29 Disease Relevance 15.10 Pain Relevance 1.37

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

Anatomy Link Frequency epithelial cells 2 lung 2 blood 1 colon 1 brain 1 RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 36 98.48 aspirin 32 92.56 ischemia 29 91.84 Opioid 1 89.12 fibrosis 11 86.00 antagonist 76 82.12 Dopamine 4 79.60 Inflammatory response 7 73.60 Inflammation 33 61.68 imagery 4 59.68

Disease Link Frequency Relevance Heat Atherosclerosis 28 100.00 Breast Cancer 130 99.84 Lung Cancer 44 99.84 Cardiovascular Disease 10 99.84 Apoptosis 180 99.72 Death 40 99.62 Cancer 503 99.56 Hyperplasia 5 99.52 Myocardial Infarction 109 99.16 Ovarian Cancer 83 98.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Specific RAS training with haptic feedback

Gene_expression (training) of RAS

1) Confidence 0.54 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

This states the obvious, because haptics are completely lacking in current RAS.

Neg (lacking) Gene_expression (lacking) of RAS

2) Confidence 0.54 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

Minimal invasive surgery: comparing conventional endoscopic surgery with robotic-assisted endoscopic surgery: The principle of MIS (e.g., operating through minimal incisions) is the same in CES as it is in RAS; however, there are some differences.

Gene_expression (is) of RAS

3) Confidence 0.54 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0.12 Pain Relevance 0.06

And, most importantly, are results in CES or RAS improving by adding haptic feedback?

Gene_expression (results) of RAS

4) Confidence 0.54 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

Considerable evidence now indicates that a separate and distinct renin-angiotensin system (RAS) is present within the brain.

Gene_expression (present) of RAS in brain

5) Confidence 0.45 Published 1992 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 1361394 Disease Relevance 0 Pain Relevance 0

To examine the reactivity of the sera in immunoblotting as well as the response at the cellular level, soluble RAs present in retinal extract were used.

Gene_expression (present) of RAs

6) Confidence 0.42 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0.25 Pain Relevance 0

We examined 77 non-small cell lung cancer (NSCLC) cell lines for mutations of 3 ras genes and p53 gene, and ras mutations were detected by designed RFLP assay generated by mismatched primers during the PCR step and p53 gene mutations were detected using SSCP analysis.

Gene_expression (detected) of ras in lung associated with lung cancer and non-small-cell lung cancer

7) Confidence 0.41 Published 1992 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 1361656 Disease Relevance 0.34 Pain Relevance 0

Although RAS mediators are present in the blood and microcirculatory structures during sepsis, the relationships between RAS and microvascular function during clinical sepsis have not been investigated.

Gene_expression (present) of RAS in blood associated with sepsis

8) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.88 Pain Relevance 0.07

Measurements of RAS activity

Gene_expression (activity) of RAS

9) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0 Pain Relevance 0.08

Since elevated activation of the RAS signaling pathway, including overexpression of HER-2/neu and mutations of RAS and BRAF, is common in human ovarian carcinoma, we examined the cellular effect of oncogenic RAS on the expression status of OPCML in a genetically defined human ovarian cancer model.

Gene_expression (overexpression) of RAS associated with ovarian cancer

10) Confidence 0.39 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.47 Pain Relevance 0.09

Immunoblotting analysis was performed as follows: retinal extracts (10 µg of proteins) or purified RAs (1.0 µg) were resolved in SDS-PAGE using 12% acrylamide gels and transferred onto nitrocellulose membranes (Schleicher & Schuell, Dassel, Germany).

Gene_expression (transferred) of RAs

11) Confidence 0.33 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0 Pain Relevance 0

The homogenate was centrifuged at 30,000×g for 30 min at 4°C and supernatant containing soluble proteins (the retinal extract) was collected and further used as a source of RAs.

Gene_expression (source) of RAs

12) Confidence 0.33 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0.06 Pain Relevance 0

Aldosterone is also operative in this pathological production of fibrous tissue [26] RAS and atherosclerosis

Gene_expression (production) of RAS associated with atherosclerosis

13) Confidence 0.29 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.17 Pain Relevance 0.14

The RAS in cardiovascular disease

Gene_expression (The) of RAS associated with cardiovascular disease

14) Confidence 0.25 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.01 Pain Relevance 0.05

Aldosterone is also operative in this pathological production of fibrous tissue [26] RAS and atherosclerosis

Gene_expression (atherosclerosis) of RAS associated with atherosclerosis

15) Confidence 0.25 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.17 Pain Relevance 0.14

Conversely, inhibition of Ras activation resulted in radiosensitization both in rodent cells transfected with Ras and in human tumor cells bearing endogenous mutations in Ras [26].

Gene_expression (transfected) of Ras associated with cancer

16) Confidence 0.18 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.34 Pain Relevance 0

Loss of let-60/Ras suppressed let-7 miRNA complementary sites, restricting reporter gene expression in a let-7-dependent manner. let-7 miRNA expression was lower in lung tumors than in normal lung tissue, while Ras protein was significantly higher in lung tumors, providing a possible mechanism for let-7 miRNA in cancer [39].

Gene_expression (higher) of Ras in lung associated with lung cancer and cancer

17) Confidence 0.14 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.65 Pain Relevance 0

The hsa-miR-200c is strongly associated with overall patient survival (Figure 2). hsa-miR-200c can potentially regulate over 200 target genes including MAPKKK3, eIF-4E, RAS homologs, RNA polymerase II, and cyclin L1 based on bioinformatics analysis (John et al. 2004).

Gene_expression (homologs) of RAS

18) Confidence 0.13 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.19 Pain Relevance 0

In the ectocervix, epithelial cells differentiate from immature toward aged cells, which undergo apoptosis with p53 and ras expression (Fig. 5I and 5L).

Gene_expression (expression) of ras in epithelial cells associated with apoptosis

19) Confidence 0.11 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.32 Pain Relevance 0

Apoptotic cell death is accompanied by expression of p53 and ras proteins [19, 20].

Gene_expression (expression) of ras in Apoptotic cell associated with apoptosis and death

20) Confidence 0.11 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.57 Pain Relevance 0

General Comments

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