INT80685

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Context Info
Confidence 0.72
First Reported 1999
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 90
Total Number 98
Disease Relevance 51.91
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
brains 6
fibroblasts 4
chondrocytes 3
epithelial cells 2
HT-29 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 17 99.52 Very High Very High Very High
Inflammatory stimuli 36 99.26 Very High Very High Very High
Osteoarthritis 943 99.24 Very High Very High Very High
Morphine 10 99.10 Very High Very High Very High
metalloproteinase 278 98.20 Very High Very High Very High
agonist 97 97.60 Very High Very High Very High
Inflammation 1134 97.52 Very High Very High Very High
bradykinin 682 97.40 Very High Very High Very High
Hippocampus 19 97.28 Very High Very High Very High
aspirin 33 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1289 100.00 Very High Very High Very High
Apoptosis 804 100.00 Very High Very High Very High
Alzheimer's Dementia 423 100.00 Very High Very High Very High
Amyloid Plaque 393 99.90 Very High Very High Very High
Disease 2060 99.84 Very High Very High Very High
Death 347 99.40 Very High Very High Very High
Frailty 273 99.24 Very High Very High Very High
Periodontitis 170 99.16 Very High Very High Very High
INFLAMMATION 1313 99.10 Very High Very High Very High
Rheumatoid Arthritis 1081 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, silencing of JNK expression by siJNKs (24), which efficiently reduced the endogenous JNK protein level (Fig. 5E) but not the control siRNA, decreased H2O2-induced AICD level (Fig. 5E, compare lanes 4 and 6 to lane 2).
Gene_expression (expression) of JNK
1) Confidence 0.72 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.10 Pain Relevance 0
Thus, the present study clearly shows that morphine-induced apoptosis in SH-SY5Y cells involves JNK-dependent activation of the mitochondrial death pathway, and that ROS signaling exerts positive feedback regulation of JNK activity.
Gene_expression (activation) of JNK-dependent in SH-SY5Y associated with apoptosis, death and morphine
2) Confidence 0.66 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.42 Pain Relevance 0.63
These results may indicate that TCA activation of JNK1/2 in the liver is primarily through stimulation of the synthesis of FGF15/19 in the intestine (ileum) (7).
Gene_expression (/) of JNK1 in liver
3) Confidence 0.65 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.19 Pain Relevance 0.32
Aging and
                       obesity reduced phosphorylation of Akt, eNOS and p38 while promoting pJNK
                       and pI?
Gene_expression (promoting) of JNK associated with aging and obesity
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 1.01 Pain Relevance 0
We investigated the expression of the active forms of NF-kappaB, JNK and p38 MAPK using immunohistochemistry with activation specific antibodies in human colonic adenomas.
Spec (investigated) Gene_expression (expression) of JNK associated with adenoma
5) Confidence 0.64 Published 2001 Journal Oncogene Section Abstract Doc Link 11314016 Disease Relevance 0.86 Pain Relevance 0.22
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps.
Gene_expression (expressed) of JNK in stroma associated with cox2 and adenomatous polyps
6) Confidence 0.64 Published 2001 Journal Oncogene Section Title Doc Link 11314016 Disease Relevance 0.84 Pain Relevance 0.32
To test whether JNK is involved in activation of ?
Gene_expression (test) of JNK
7) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.26 Pain Relevance 0
To determine the link between amyloid deposits and JNK activation, we performed an immunostaining in brains of the AD animal model (Tg2576 mice) and found that phospho-JNK immunoreactivity was localized in the surrounding region of senile plaques, which was positive with A?
Gene_expression (activation) of JNK in brains associated with alzheimer's dementia and amyloid plaque
8) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.83 Pain Relevance 0.04
To test whether JNK is involved in activation of ?
Spec (whether) Gene_expression (whether) of JNK
9) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.26 Pain Relevance 0
peptide through JNK-dependent, ?
Gene_expression (through) of JNK
10) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 1.07 Pain Relevance 0
To determine the link between amyloid deposits and JNK activation, we performed an immunostaining in brains of the AD animal model (Tg2576 mice) and found that phospho-JNK immunoreactivity was localized in the surrounding region of senile plaques, which was positive with A?
Gene_expression (immunoreactivity) of JNK in brains associated with alzheimer's dementia and amyloid plaque
11) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.88 Pain Relevance 0.04
The level of phosphorylated JNK was evidently increased in the brains of AD patients when compared with control brains, whereas there was no significant difference in JNK expression level (Fig. 7A), consistent with previous reports (36, 37).


Gene_expression (expression) of JNK in brains associated with alzheimer's dementia
12) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.76 Pain Relevance 0.04
The level of phosphorylated JNK was evidently increased in the brains of AD patients when compared with control brains, whereas there was no significant difference in JNK expression level (Fig. 7A), consistent with previous reports (36, 37).


Gene_expression (expression) of JNK in brains associated with alzheimer's dementia
13) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.78 Pain Relevance 0.05
production in vivo, we examined JNK activation in brain tissues of AD patients.
Spec (examined) Gene_expression (activation) of JNK in brain associated with alzheimer's dementia
14) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.58 Pain Relevance 0.05
In contrast, both senile plaques and phospho-JNK were negative in the brains of control nontransgenic littermates (data not shown).
Neg (negative) Gene_expression (negative) of JNK in brains associated with amyloid plaque
15) Confidence 0.62 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 1.04 Pain Relevance 0.03
Here we show that NaSal treatment of COS-1 or HT-29 cells produced a sustained c-Jun N-terminal kinase (JNK) activation.
Gene_expression (produced) of c-Jun N-terminal kinase in HT-29
16) Confidence 0.59 Published 1999 Journal J. Cell. Physiol. Section Abstract Doc Link 10082138 Disease Relevance 0.25 Pain Relevance 0.12
Here we show that NaSal treatment of COS-1 or HT-29 cells produced a sustained c-Jun N-terminal kinase (JNK) activation.
Gene_expression (produced) of JNK in HT-29
17) Confidence 0.59 Published 1999 Journal J. Cell. Physiol. Section Abstract Doc Link 10082138 Disease Relevance 0.25 Pain Relevance 0.12
production through c-Jun N-terminal kinase (JNK)-dependent activation of ?
Gene_expression (production) of c-Jun N-terminal kinase
18) Confidence 0.56 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2427353 Disease Relevance 0.89 Pain Relevance 0
Cell cycle inhibition has been explained by activation of the c-Jun-N-terminal kinase (JNK) and downregulation of cyclin D1 expression.
Gene_expression (expression) of JNK
19) Confidence 0.51 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.67 Pain Relevance 0.13
Western blot analysis revealed that EBC1-Ps had higher JNK phosphorylation levels than EBC1-Vs, and sp600125-treated EBC1-Ps showed similar levels of phosphorylated JNK as in EBC1-Vs (Figure 6B).
Gene_expression (had) of JNK
20) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.05 Pain Relevance 0

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