INT80688

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 8
Speculated 1
Reported most in Abstract
Documents 72
Total Number 79
Disease Relevance 39.35
Pain Relevance 14.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblasts 24
myometrium 8
epithelial cells 6
chondrocytes 2
macrophages 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 1016 100.00 Very High Very High Very High
dexamethasone 19 100.00 Very High Very High Very High
cytokine 394 99.98 Very High Very High Very High
qutenza 42 99.98 Very High Very High Very High
substance P 18 99.80 Very High Very High Very High
Nicotine 96 99.78 Very High Very High Very High
Sumatriptan 1 99.70 Very High Very High Very High
Peripheral nerve injury 1 99.56 Very High Very High Very High
Paracetamol 2 99.40 Very High Very High Very High
Serotonin 34 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1412 100.00 Very High Very High Very High
Down Syndrome 208 100.00 Very High Very High Very High
Disease 2625 99.74 Very High Very High Very High
Cancer 300 99.62 Very High Very High Very High
Nervous System Injury 2 99.56 Very High Very High Very High
Apoptosis 475 99.50 Very High Very High Very High
Colorectal Cancer 23 99.42 Very High Very High Very High
Infection 148 99.20 Very High Very High Very High
Melanoma 73 99.20 Very High Very High Very High
Glioma 37 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed an increase in ERK activation by 5-HT with a peak effect at 30 min and maximal stimulation with 5-HT at 1microM.
Positive_regulation (increase) of Positive_regulation (activation) of ERK
1) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.11
These results indicate that transactivation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase (ERK) are essential for substance P/NK-1 receptor-induced activation of Egr-1 biosynthesis.
Positive_regulation (essential) of Positive_regulation (stimulation) of ERK associated with substance p
2) Confidence 0.58 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.46 Pain Relevance 0.51
Three structurally unrelated nonsteroidal antiinflammatory drugs (ibuprofen, acetaminophen, and indomethacin) failed to induce significant activation of JNK or p38 MAPK, suggesting that cyclooxygenase inhibition is not the underlying mechanism whereby salicylates induce p38 MAPK and JNK activation.
Positive_regulation (induce) of Positive_regulation (activation) of p38 MAPK associated with paracetamol and inflammation
3) Confidence 0.56 Published 1999 Journal J. Cell. Physiol. Section Abstract Doc Link 10082138 Disease Relevance 0.23 Pain Relevance 0.14
The above data demonstrate that the existence of stretch-sensitive elements in the pregnant myometrium that result in ERK and CaD activation.
Positive_regulation (result) of Positive_regulation (activation) of ERK in myometrium
4) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 8B and 8C, stretching human pregnant uterine smooth muscle induces a significant increase in ERK-SmAV and the pERK-SmAV interactions.
Positive_regulation (induces) of Positive_regulation (increase) of ERK-SmAV in uterine smooth muscle
5) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.33 Pain Relevance 0
The effect of 5-HT on ERK activation appeared to be mediated through the activation of 5-HT1A receptors since similar results were obtained with R-+-8-hydroxy-DPAT, a selective 5-HT1A receptor agonist and WAY100635, a selective 5-HT1A receptor antagonist, reversed the 5-HT and the R-+-8-hydroxy-DPAT effects.
Positive_regulation (mediated) of Positive_regulation (activation) of ERK associated with antagonist and agonist
6) Confidence 0.50 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.24
To determine whether mechanosensitive ion channels participate in the EC response to shear stress, we characterized the role of ion transport in shear stress-mediated extracellular signal-regulated kinase (ERK1/2) stimulation.
Positive_regulation (stress-mediated) of Positive_regulation (stimulation) of extracellular signal-regulated kinase associated with stress
7) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.60 Pain Relevance 0.18
Together, our findings provide a unifying mechanism for pain hypersensitivity after peripheral nerve injury through P2X4R-evoked increase in Ca(2+) and activation of p38-MAPK leading to the synthesis and exocytotic release of BDNF from microglia.
Positive_regulation (increase) of Positive_regulation (activation) of p38 in microglia associated with nervous system injury, hypersensitivity, stimulus evoked pain and peripheral nerve injury
8) Confidence 0.49 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.40 Pain Relevance 0.20
Treatment of HT29 colorectal carcinoma cells with 75 microM NS-398 caused activation of ERK-1/-2 but not of the p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases.
Positive_regulation (caused) of Positive_regulation (activation) of ERK associated with colorectal cancer
9) Confidence 0.48 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.64 Pain Relevance 0.15
Treatment of HT29 colorectal carcinoma cells with 75 microM NS-398 caused activation of ERK-1/-2 but not of the p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases.
Positive_regulation (caused) of Positive_regulation (activation) of p38 associated with colorectal cancer
10) Confidence 0.48 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.65 Pain Relevance 0.15
Taurine was also shown to stimulate the activation of ERK 1/2.
Positive_regulation (stimulate) of Positive_regulation (activation) of ERK
11) Confidence 0.47 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 18036343 Disease Relevance 0.26 Pain Relevance 0.10
We also demonstrate upregulation of activated p38 and ERK1/2 MAP kinases in axons within these neuromas.
Positive_regulation (upregulation) of Positive_regulation (activated) of p38
12) Confidence 0.46 Published 2008 Journal Ann. Neurol. Section Body Doc Link 19107992 Disease Relevance 0.16 Pain Relevance 0
Furthermore, treatment with 3MA markedly down-regulated capsaicin-induced p38 activation and LC3 conversion, and BaF1 completely down-regulated ERK activation and led to LC3II accumulation.
Positive_regulation (induced) of Positive_regulation (activation) of p38 associated with qutenza
13) Confidence 0.46 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.61 Pain Relevance 0.74
CM-induced levels of NO production, iNOS expression and ERK activation were evaluated.
Positive_regulation (induced) of Positive_regulation (activation) of ERK
14) Confidence 0.45 Published 2009 Journal Nitric Oxide Section Abstract Doc Link 18976718 Disease Relevance 0.30 Pain Relevance 0.15
CM stimulated a rapid increase in the activity of ERK, whereas epimagnolin and fargesin inhibited ERK phosphorylation.
Positive_regulation (stimulated) of Positive_regulation (increase) of ERK
15) Confidence 0.45 Published 2009 Journal Nitric Oxide Section Abstract Doc Link 18976718 Disease Relevance 0.25 Pain Relevance 0.14
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Positive_regulation (activation) of Positive_regulation (induced) of ERK
16) Confidence 0.45 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.26
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Positive_regulation (induced) of Positive_regulation (activation) of ERK
17) Confidence 0.45 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.26
U0126 dose-dependently protected HT29 cells from these antiproliferative effects of NS-398, indicating an antiproliferative role for sustained ERK-1/-2 activation in response to this NSAID.
Positive_regulation (role) of Positive_regulation (activation) of ERK associated with cinod
18) Confidence 0.45 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.50 Pain Relevance 0.26
Results demonstrated that all three cytokines could trigger the receptor-mediated activation of extracellular signal-regulated kinase (ERK) within one hour but not p38 MAPK activity in EoL-1 cells.
Neg (not) Positive_regulation (trigger) of Positive_regulation (activation) of ERK associated with cytokine
19) Confidence 0.44 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.75 Pain Relevance 0.38
Western blotting revealed the activation of extracellular signal-regulated kinase (ERK), p38 MAPK, and c-Jun N-terminal kinase (JNK) with indomethacin treatment.
Positive_regulation (revealed) of Positive_regulation (activation) of extracellular signal-regulated kinase
20) Confidence 0.44 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.02 Pain Relevance 0.18

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