INT8071

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 5
Speculated 11
Reported most in Abstract
Documents 102
Total Number 113
Disease Relevance 26.61
Pain Relevance 53.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
plasma 5
spinal cord 5
hippocampus 4
neurons 4
brain 3
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 2909 100.00 Very High Very High Very High
nMDA receptor 421 100.00 Very High Very High Very High
antagonist 392 100.00 Very High Very High Very High
Glutamate 297 100.00 Very High Very High Very High
Glutamate receptor 282 100.00 Very High Very High Very High
Spinal cord 191 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
dopamine receptor 17 100.00 Very High Very High Very High
c fibre 13 100.00 Very High Very High Very High
Dopamine 264 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 245 99.98 Very High Very High Very High
Stress 306 99.80 Very High Very High Very High
Toxicity 16 99.68 Very High Very High Very High
Diabetes Mellitus 261 99.52 Very High Very High Very High
Nociception 114 99.36 Very High Very High Very High
Depression 140 99.28 Very High Very High Very High
Hypoxia 10 99.12 Very High Very High Very High
Inflammatory Pain 172 98.88 Very High Very High Very High
Apoptosis 4 98.82 Very High Very High Very High
Anaerobic Bacterial Infections 1 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine causes a delayed increase in glutamate receptor functioning in the nucleus accumbens core.
Positive_regulation (increase) of glutamate receptor in nucleus accumbens associated with nucleus accumbens, glutamate receptor and morphine
1) Confidence 0.70 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 15777776 Disease Relevance 0 Pain Relevance 0.64
This delayed increase in glutamate receptor functioning is associated with enhanced gene transcript levels of ionotropic NMDA and AMPA/kainate receptor subunits.
Positive_regulation (increase) of glutamate receptor associated with glutamate receptor
2) Confidence 0.70 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15777776 Disease Relevance 0 Pain Relevance 0.65
Elevated GluR1 was accompanied by sustained increases in the gene for GluR1, whereas elevated GluR2 was accompanied by decreases in prodynorphin.
Positive_regulation (increases) of GluR1
3) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.06 Pain Relevance 0.40
To confirm that viral vector-mediated elevations of GluR1 in the NAc shell produce molecular consequences that are different from those of elevated GluR2, we examined the expression of a set of drug-regulated genes 3 d after treatment using quantitative PCR.
Spec (examined) Positive_regulation (elevations) of GluR1 in NAc associated with nucleus accumbens
4) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.07 Pain Relevance 0.44
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Positive_regulation (upregulated) of GRIA1 in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
5) Confidence 0.67 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.32
45 h after IA training, prevent the rapid increase in GluR1 protein induced by IA training necessary for memory consolidation.
Positive_regulation (increase) of GluR1 protein
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.08 Pain Relevance 0.19
Repeated dopamine (DA) treatment, which leads to upregulation of surface GluR1 and GluR2, occluded activity blockade-induced synaptic scaling.
Positive_regulation (upregulation) of GluR1 associated with dopamine
7) Confidence 0.66 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0 Pain Relevance 0.60
It was found that the GluR1-flop mRNA was up-regulated at 2 h-5 h (P<0.05), down-regulated at 3 d (P=0.05), and returned to control levels at 7 d following inflammation.
Positive_regulation (up-regulated) of GluR1 associated with inflammation
8) Confidence 0.65 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.81 Pain Relevance 0.60
Repeated restraint stress also paradigm (2 stressors/d under variable conditions) increased both GluR1 and NMDAR1 levels in this brain region.
Positive_regulation (increased) of GluR1 in brain associated with stress
9) Confidence 0.63 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.43 Pain Relevance 1.13
In addition, GluR1 ASO hinders the BDNF/mTOR dependent increase in GluR1 in synaptic plasma membranes and causes a clear-cut LTM deficit 24 h after training.
Positive_regulation (increase) of GluR1 in plasma
10) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.07
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Positive_regulation (increase) of GLUR1 in hippocampus associated with nucleus accumbens, hippocampus and cocaine
11) Confidence 0.57 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.33
Although morphine delivered by subcutaneous pellet implantation had no significant effect on subunit levels, morphine delivered intermittently by subcutaneous injections of escalating doses elevated GluR1 levels in the VTA.
Positive_regulation (elevated) of GluR1 associated with ventral tegmentum and morphine
12) Confidence 0.55 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.43 Pain Relevance 1.24
Western blotting on tissue taken from around the cannula tips in the LA was then performed to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs.
Spec (whether) Positive_regulation (activation) of GluR1 in synapses associated with amygdala
13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.55 Pain Relevance 0.39
Following infusion, rats were trained, then sacrificed 24 hours after training as in our previous experiments, and Western blotting was performed on LA homogenates to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs (Figure 5a).
Spec (whether) Positive_regulation (activation) of GluR1 in synapses associated with amygdala
14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.17 Pain Relevance 0.36
The levels of mRNA for the flip form of GluR-A were increased in the parietal cortex (7%) and the entorhinal cortex (8%).
Positive_regulation (increased) of GluR-A in parietal cortex
15) Confidence 0.49 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10822164 Disease Relevance 0.05 Pain Relevance 0.93
In the BLA of morphine self-administering animals, there was a significant increase in the proportion of immunogold particles for GluR1 on the plasma membrane of dendrites, particularly in association with extrasynaptic sites, which was most prominent in large (2-4 microm) profiles.
Positive_regulation (increase) of GluR1 in plasma associated with morphine
16) Confidence 0.49 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0.07 Pain Relevance 0.86
Moreover, it was reported that the transcript levels for GluR1, GluR2, GluR3, NR2A, and NR2B subunits are significantly upregulated in the dorsal horn of the spinal cord in STZ-induced diabetic rats [21].
Positive_regulation (upregulated) of GluR1 in spinal cord associated with diabetes mellitus, dorsal horn and spinal cord
17) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.20 Pain Relevance 0.46
However, the postsynaptic AMPA and NMDA receptor subunits, GluR1, NR1 and NR2B, were increased.
Positive_regulation (increased) of GluR1 associated with nmda receptor
18) Confidence 0.47 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622219 Disease Relevance 0.08 Pain Relevance 0.86
We found that elevated GluR1 in NAc shell increases ICSS thresholds, an effect similar to that caused by treatments that cause anhedonia and dysphoria (prodepressive effects) in rats and humans (e.g., drug withdrawal, kappa-opioid agonists).
Positive_regulation (elevated) of GluR1 in shell associated with nucleus accumbens, mu agonist and withdrawal
19) Confidence 0.47 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.09 Pain Relevance 0.43
These results indicate that striatal projection neurons selectively target GluR1 subunits to their spines and dendritic shafts.
Positive_regulation (target) of GluR1 in projection neurons associated with projection neuron
20) Confidence 0.46 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483559 Disease Relevance 0 Pain Relevance 0.57

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