INT80712

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 13.08
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER4) signal transducer activity (PTGER4)
Anatomy Link Frequency
chondrocytes 6
eosinophils 3
PGE2 2
HT-29 1
nasal 1
PTGER4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 269 99.26 Very High Very High Very High
Snapping jaw 56 97.88 Very High Very High Very High
Hyperalgesia 7 97.60 Very High Very High Very High
Pain 18 96.92 Very High Very High Very High
agonist 52 95.52 Very High Very High Very High
Inflammatory stimuli 21 94.48 High High
antagonist 20 91.68 High High
cINOD 44 90.80 High High
Osteoarthritis 27 90.40 High High
cytokine 53 87.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 323 99.26 Very High Very High Very High
Colorectal Cancer 36 99.00 Very High Very High Very High
Rhinitis 113 98.74 Very High Very High Very High
Cyst 7 98.26 Very High Very High Very High
Skin Cancer 10 97.92 Very High Very High Very High
Temporomandibular Joint Syndrome 56 97.88 Very High Very High Very High
Chronic Sinusitis 168 97.66 Very High Very High Very High
Hyperalgesia 7 97.60 Very High Very High Very High
Asthma 49 97.56 Very High Very High Very High
Pain 17 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prostaglandin EP2 and EP4 receptors were detected by reverse transcription-polymerase chain reaction.
Gene_expression (detected) of EP4
1) Confidence 0.65 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.50 Pain Relevance 0.26
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Gene_expression (synthesis) of EP4 in PGE2
2) Confidence 0.65 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.25 Pain Relevance 0.70
Results showed that HKESC-1 cells expressed all four series of prostaglandin (EP) receptors, namely, EP1 to EP4 receptors.
Gene_expression (expressed) of EP4
3) Confidence 0.65 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.60 Pain Relevance 0.13
With respect to PGE2 receptors, CRC cells and their neighboring cells have augmented expression of receptors EP2 and EP4, while initially the EP3 receptor expression often is lowered [4,8,12-15], Figure 1.
Gene_expression (expression) of EP4 in PGE2 associated with colorectal cancer
4) Confidence 0.37 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.77 Pain Relevance 0.41
stimulated the expression of the EP4 receptor via an autocrine mechanism involving PGE2 production in human chondrocytes [23].
Gene_expression (expression) of EP4 receptor in chondrocytes
5) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.06 Pain Relevance 0
increases the production of PGE2, COX-2, and EP4 receptor in the same chondrocytes as used in this study [23].
Gene_expression (production) of EP4 receptor in chondrocytes
6) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.13
may promote the expression of EP4 by increasing PGE2 production in chondrocytes [23].
Gene_expression (expression) of EP4 in chondrocytes
7) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.20 Pain Relevance 0.14
increased the production of prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and prostaglandin receptor EP4 in human chondrocytes, suggesting that IL-1?
Gene_expression (production) of EP4 in chondrocytes
8) Confidence 0.31 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.32 Pain Relevance 0.26
promotes the expression of EP4 by an autocrine mechanism involving increased PGE2 production in chondrocytes [23].
Gene_expression (expression) of EP4 in chondrocytes
9) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.69 Pain Relevance 0.52
Furthermore, an in vitro study performed on inflammatory cells demonstrated that eosinophils express high levels of EP2 and EP4 mRNA in comparison with EP1 and EP3, which were almost not present in these cells and that deficiency of PGE2 production may up-regulate the expression of EP2 and EP4 molecules [30].
Gene_expression (express) of EP4 mRNA in eosinophils associated with inflammation
10) Confidence 0.26 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.37 Pain Relevance 0.29
Furthermore, an in vitro study performed on inflammatory cells demonstrated that eosinophils express high levels of EP2 and EP4 mRNA in comparison with EP1 and EP3, which were almost not present in these cells and that deficiency of PGE2 production may up-regulate the expression of EP2 and EP4 molecules [30].
Gene_expression (expression) of EP4 in eosinophils associated with inflammation
11) Confidence 0.26 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.32 Pain Relevance 0.25
stimulated the expression of prostaglandin (PG) receptor EP4 via increased PGE2 production.
Gene_expression (expression) of EP4
12) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
increased the production of PGE2, COX-2, and PG receptor EP4 in human chondrocytes, suggesting that the IL-1?
Gene_expression (production) of EP4 in chondrocytes
13) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.72 Pain Relevance 0.55
However, in the CRS and EP1 and EP3 receptors were down-expressed compared to EP2 and EP4 and this difference was more accentuated in the CRS-NP subjects.
Gene_expression (expressed) of EP4
14) Confidence 0.22 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.22 Pain Relevance 0.07
The results of this analysis, shown in Fig. 7A, evidenced that HT-29 cells express EP1, EP2 and EP4 receptors but no EP3.
Neg (no) Gene_expression (express) of EP4 in HT-29
15) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.07 Pain Relevance 0.24
CRS and controls, whereas EP2 and EP4 expression was enhanced in CRS and CRS-NP patients vs. controls.
Gene_expression (expression) of EP4
16) Confidence 0.20 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 0.90 Pain Relevance 0.11
Basal expression of EP2 and EP4 receptors is increased on bronchial inflammatory cells from asthmatic patients and may be altered in vitro on eosinophils in response to inflammatory stimuli, suggesting the immunomodulatory role of these receptors in asthma, [15].
Gene_expression (expression) of EP4 in eosinophils associated with asthma, inflammation and inflammatory stimuli
17) Confidence 0.20 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.61 Pain Relevance 0.31
Samples were prepared from nasal tissue of patients with chronic rhinosinusitis without nasal polyps (CRS, n = 11), with nasal polyps (CRS-NP, n = 13) and healthy subjects (Controls, n = 6). mRNA expression of CysLT1, CysLT2, BLT1, BLT2, E-prostanoid receptors (EP1, EP2, EP3, EP4) and sol-IL-5R?
Gene_expression (expression) of EP4 in nasal associated with rhinitis and chronic sinusitis
18) Confidence 0.20 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 1.11 Pain Relevance 0.12
The prostanoid receptor subfamily comprises eight members: the prostaglandin D (DP) receptor, the prostaglandin E2 receptors (EP1, EP2, EP3 and EP4), the prostaglandin F receptor (FP), the prostaglandin I receptor (IP), the tromboxane A receptor (TP), and a ninth prostaglandin receptor identified recently, the chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) [12].
Gene_expression (expressed) of EP4 in Th2 cells
19) Confidence 0.09 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.53 Pain Relevance 0.25
In contrary to EP2 and EP4, EP3 is coupled with Gi protein, leading to an inhibition of adenylate cyclase, and thus a decrease of cAMP inside the cells [41].
Gene_expression (coupled) of EP4
20) Confidence 0.08 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.89 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox