INT80717

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Context Info
Confidence 0.72
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 10.05
Pain Relevance 9.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv3)
Anatomy Link Frequency
primary sensory neurons 3
sensory neurons 2
neurons 2
skin 2
keratinocytes 2
Trpv3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 672 100.00 Very High Very High Very High
qutenza 184 100.00 Very High Very High Very High
antagonist 272 99.96 Very High Very High Very High
orphanin 23 99.88 Very High Very High Very High
nociceptor 347 99.84 Very High Very High Very High
Spinal cord 50 98.96 Very High Very High Very High
TRP channel 53 98.88 Very High Very High Very High
analgesia 71 98.68 Very High Very High Very High
agonist 238 98.04 Very High Very High Very High
Dorsal horn 84 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 694 100.00 Very High Very High Very High
Alopecia 7 99.56 Very High Very High Very High
Injury 18 98.88 Very High Very High Very High
Targeted Disruption 176 98.24 Very High Very High Very High
Ganglion Cysts 137 97.08 Very High Very High Very High
INFLAMMATION 109 95.68 Very High Very High Very High
Hypotension 7 95.68 Very High Very High Very High
Heart Rate Under Development 4 95.16 Very High Very High Very High
Cancer 28 93.28 High High
Nociception 127 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV3, another heat-activated ion channel but insensitive to capsaicin, was shown to be expressed in keratinocytes as well as in sensory neurons projecting to the skin.
Gene_expression (expressed) of TRPV3 in skin associated with qutenza
1) Confidence 0.72 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165301 Disease Relevance 0.07 Pain Relevance 0.35
Interestingly, TRPV3 and TRPV4 are predominantly expressed in skin keratinocytes, suggesting that warm stimuli can be initially detected in skin [7, 10, 13, 33, 38].
Gene_expression (expressed) of TRPV3 in keratinocytes
2) Confidence 0.72 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0 Pain Relevance 0.21
In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and recovery took a long time.
Gene_expression (expression) of TRPV3
3) Confidence 0.70 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.13
These channels exhibit distinct thermal activation thresholds (>43 degrees C for TRPV1, >52 degrees C for TRPV2, >32-39 degrees C for TRPV3, >27-35 degrees C for TRPV4, <25-28 degrees C for TRPM8, and <17 degrees C for TRPA1) and are expressed in primary sensory neurons as well as other tissues.
Gene_expression (expressed) of TRPV3 in primary sensory neurons
4) Confidence 0.66 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467255 Disease Relevance 0.25 Pain Relevance 0.18
Unexpectedly, TRPV3 mRNA expression was upregulated in shRNAtg but downregulated in knockout mice.
Gene_expression (expression) of TRPV3 associated with targeted disruption
5) Confidence 0.65 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.77 Pain Relevance 0.40
TRPV1, TRPV2, TRPV3 and TRPV4 mRNAs were expressed in spiral and vestibular ganglia, and TRPV2 and TRPV1 mRNAs were most predominant in control mice.
Gene_expression (expressed) of TRPV3 in ganglia
6) Confidence 0.62 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.08 Pain Relevance 0.23
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP

Transient receptor potential V3 (TRPV3) and TRPV4 are heat-activated cation channels expressed in keratinocytes.

Gene_expression (expressed) of TRPV3 in keratinocytes
7) Confidence 0.56 Published 2009 Journal Pflugers Arch Section Title Doc Link PMC2745623 Disease Relevance 0.35 Pain Relevance 0.26
9), but not from TRPV3-deficient (TRPV3KO) mice (b, n?
Gene_expression (deficient) of TRPV3KO
8) Confidence 0.55 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0.52 Pain Relevance 0.28
In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and took a long time to recover.
Gene_expression (expression) of TRPV3
9) Confidence 0.55 Published 2010 Journal Acta Oto-Laryngologica Section Abstract Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.04
These channels exhibit distinct thermal activation thresholds (> 52 degrees C for TRPV2, > approximately 34-38 degrees C for TRPV3, > approximately 27-35 degrees C for TRPV4, < approximately 25-28 degrees C for TRPM8 and < 17 degrees C for TRPA1) and are expressed in primary sensory neurons as well as other tissues.
Gene_expression (expressed) of TRPV3 in primary sensory neurons
10) Confidence 0.52 Published 2004 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 15578965 Disease Relevance 0.71 Pain Relevance 0.78
These channels exhibit distinct thermal activation thresholds (>43 degrees C for TRPV1, >52 degrees C for TRPV2, > approximately 34-38 degrees C for TRPV3, > approximately 27-35 degrees C for TRPV4, < approximately 25-28 degrees C for TRPM8 and <17 degrees C for TRPA1), and are expressed in primary sensory neurons as well as other tissues.
Gene_expression (expressed) of TRPV3 in primary sensory neurons
11) Confidence 0.50 Published 2004 Journal J. Neurobiol. Section Abstract Doc Link 15362149 Disease Relevance 0.33 Pain Relevance 0.16
One study showed an increase in TRPV3 expression following brachial plexus avulsion, however, its symptoms are not pain related [190].
Gene_expression (expression) of TRPV3 in brachial plexus associated with pain
12) Confidence 0.26 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.87 Pain Relevance 0.51
CNS expression of TRPV3 includes ventral motor neurons, deeper laminae of DH, superior cervical ganglion neurons, nigral dopaminergic neurons [70, 60, 190, 239].
Gene_expression (expression) of TRPV3 in neurons associated with ganglion cysts and dorsal horn
13) Confidence 0.26 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.99 Pain Relevance 0.66
The close proximity of nociceptors to skin epidermal layers, where functional TRPV3 is present, makes it a potential molecule with an extended role in physiology and pathology of thermosensation and pain [26, 114].
Gene_expression (present) of TRPV3 in skin associated with pain and nociceptor
14) Confidence 0.26 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.41 Pain Relevance 0.60
Specifically, TRPV3 [35] and TRPV2 [116,117] channels have been shown to co-express, and even form heteromultimers, with TRPV1 subunits.
Gene_expression (express) of TRPV3
15) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0.06 Pain Relevance 0.10
Another feature of TRPV3 which prompts its possible role in pain is its sensitization upon repeated heat applications in skin cells and heterologous expression systems, a phenomenon yet to be confirmed in sensory neurons [32, 141, 166].
Gene_expression (expression) of TRPV3 in sensory neurons associated with pain
16) Confidence 0.22 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.82 Pain Relevance 0.53
Six TRPs (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1) have been shown to be expressed in primary afferent nociceptors, pain sensing neurons, where they act as transducers for thermal, chemical and mechanical stimuli.
Gene_expression (expressed) of TRPV3 in neurons associated with pain and nociceptor
17) Confidence 0.22 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17321113 Disease Relevance 0.74 Pain Relevance 0.81
The role of other thermoTRP’s (TRPV3 and TRPV4) encoding for detection of warm temperatures and expressed in nociceptors cannot be excluded.
Neg (cannot) Gene_expression (expressed) of TRPV3 in nociceptors associated with nociceptor
18) Confidence 0.20 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2645548 Disease Relevance 0.62 Pain Relevance 1.40
However, an increase in TRPV3 expression in peripheral nerves after injury and in avulsed DRG is documented [60].
Gene_expression (expression) of TRPV3 in peripheral nerves associated with injury
19) Confidence 0.20 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.83 Pain Relevance 0.60
Expression of TRPV3 among sensory neurons is variable between species and thus its role in somatosensation needs further investigations [166, 190, 239].
Gene_expression (Expression) of TRPV3 in sensory neurons
20) Confidence 0.20 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.74 Pain Relevance 0.59

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