INT8072

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 17
Total Number 22
Disease Relevance 2.62
Pain Relevance 10.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
plasma 1
shell 1
dendrites 1
striatum 1
brain 1
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 24 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
projection neuron 6 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
antagonist 74 99.96 Very High Very High Very High
Dopamine 135 99.84 Very High Very High Very High
amygdala 600 99.80 Very High Very High Very High
gABA 5 99.62 Very High Very High Very High
Nucleus accumbens 22 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 305 98.46 Very High Very High Very High
Cognitive Disorder 4 98.12 Very High Very High Very High
Inflammatory Pain 29 94.84 High High
Cv Unclassified Under Development 46 94.52 High High
INFLAMMATION 26 92.44 High High
Ganglion Cysts 1 90.16 High High
Nociception 20 88.40 High High
Apoptosis 1 86.12 High High
Drug Dependence 3 84.08 Quite High
Syndrome 1 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunostaining showed that GluR1 and its phosphorylated forms were localized in the superficial laminae of dorsal horn and quantitative image analysis supported the immunoblotting results.
Localization (localized) of GluR1 in dorsal horn associated with dorsal horn
1) Confidence 0.75 Published 2003 Journal Neuroscience Section Abstract Doc Link 14596864 Disease Relevance 0.07 Pain Relevance 0.52
To explore the possibility that GluR1 subunits may be synthesized by many striatal projection neurons, but selectively localized to their dendrites, we have used light-microscopic and electron-microscopic immunohistochemistry in combination with single-cell reverse transcription-polymerase chain reaction.
Localization (localized) of GluR1 in dendrites associated with projection neuron
2) Confidence 0.75 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483559 Disease Relevance 0 Pain Relevance 0.28
The cerebral cortex and parafascicular thalamic nucleus facilitate in vivo acetylcholine release in the rat striatum through distinct glutamate receptor subtypes.
Localization (release) of glutamate receptor in striatum associated with glutamate receptor and cerebral cortex
3) Confidence 0.73 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8996820 Disease Relevance 0 Pain Relevance 0.28
In both amygdala regions, GluR1 and the micro-opioid receptor, the major cellular target of morphine, were only infrequently colocalized.
Localization (colocalized) of GluR1 in amygdala associated with opioid receptor, amygdala and morphine
4) Confidence 0.73 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0.05 Pain Relevance 1.00
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
Localization (localization) of GluR1 associated with glutamate receptor and antagonist
5) Confidence 0.72 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.08 Pain Relevance 0.57
Western blots and immunohistochemistry were performed to examine the expression and localization of GluR1 and the phosphorylated forms of GluR1 (phospho-GluR1) at Ser-831 and Ser-845 with specific antibodies.
Spec (examine) Localization (localization) of GluR1
6) Confidence 0.70 Published 2003 Journal Neuroscience Section Abstract Doc Link 14596864 Disease Relevance 0.09 Pain Relevance 0.39
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
Localization (localization) of glutamate receptor 1 associated with glutamate receptor and antagonist
7) Confidence 0.67 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.08 Pain Relevance 0.58
The localization of AMPA receptor subunits (GluR1-4), a KA receptor subunit (GluR5) and NMDA receptor subunits (NR1 and NRgbs; the glutamate binding subunits of an NMDA receptor complex) was investigated using immunohistochemistry and in situ hybridization histochemistry in the rat dorsal root ganglion.
Spec (investigated) Localization (localization) of GluR1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, glutamate and nmda receptor
8) Confidence 0.66 Published 1993 Journal Neuroreport Section Abstract Doc Link 8219025 Disease Relevance 0.09 Pain Relevance 0.26
The molecular mechanisms by which GluR1 is inserted into plasma membrane and GluR2 is internalized into cytoplasm in dorsal horn neurons during the maintenance phase of persistent inflammatory pain are unclear, but they might be related to inflammation-induced spinal cord GluR1 and GluR2 phosphorylation.
Localization (inserted) of GluR1 in plasma associated with inflammation, eae, dorsal horn neuron and spinal cord
9) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.38 Pain Relevance 0.50
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Localization (localization) of GluR1 associated with glutamate and long-term potentiation
10) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.19
In the present study, we show that auditory Pavlovian fear conditioning is associated with significant and persistent increases in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin in the LA.
Localization (localized) of GluR1 associated with anxiety disorder and amygdala
11) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.30 Pain Relevance 0.29
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Localization (localized) of GluR1 associated with glutamate and long-term potentiation
12) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.18
Modification of glutamate receptor targeting may be a key mechanism mediating neural plasticity; however, evidence for alteration of amygdala AMPA receptor localization in response to drug self-administration is lacking.
Localization (targeting) of glutamate receptor in neural associated with glutamate receptor and amygdala
13) Confidence 0.47 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0.10 Pain Relevance 0.51
Auditory fear conditioning persistently regulates the expression of the postsynaptically- localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin at LA synapses
Localization (localized) of GluR1 in synapses associated with anxiety disorder and amygdala
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.40 Pain Relevance 0.42
We detected an intermittent colocalization of PAM and ubiquitin with TSC2, a known substrate of PAM, and the glutamate receptors mGluR5 and GLUR1.
Localization (colocalization) of GLUR1 associated with glutamate receptor
15) Confidence 0.44 Published 2008 Journal Mol. Cell Proteomics Section Abstract Doc Link 18753128 Disease Relevance 0.16 Pain Relevance 0.22
We have studied the characteristics associated with the activation of the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor on the release of dopamine (DA) in the striatum of awake rats as measured by brain microdialysis technique.
Localization (release) of glutamate receptor in brain associated with dopamine and glutamate receptor
16) Confidence 0.29 Published 1992 Journal Brain Res. Section Abstract Doc Link 1361416 Disease Relevance 0 Pain Relevance 0.34
In the presence of glutamate receptor antagonists CNQX (20 ?
Localization (presence) of glutamate receptor associated with antagonist and glutamate receptor
17) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC1864984 Disease Relevance 0.66 Pain Relevance 1.01
GluR1 and GluR2 surface expression was also increased by tetrodotoxin alone or in combination with an N-methyl-d-aspartate receptor or AMPA receptor antagonist but not by the l-type Ca(2+) channel antagonist nifedipine.
Localization (expression) of GluR1 associated with tetrodotoxin and antagonist
18) Confidence 0.26 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.07 Pain Relevance 0.65
Infusion of the alpha 1-selective adrenoceptor agonist, phenylephrine (1,000-2,500 micrograms.kg-1.h-1), into a lateral brain ventricle increased (P < 0.01) duodenal bicarbonate secretion.
Localization (secretion) of alpha 1-selective in brain ventricle associated with agonist
19) Confidence 0.13 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8944698 Disease Relevance 0 Pain Relevance 0.37
Next, cells were incubated with GluR1 (1?
Localization (incubated) of GluR1
20) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.06

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