INT80733

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 1.09
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
brain 1
SCN 1
parietal 1
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 44 99.98 Very High Very High Very High
Nav1.2 8 99.80 Very High Very High Very High
agonist 40 96.00 Very High Very High Very High
Glutamate 44 95.80 Very High Very High Very High
GABAergic 7 93.32 High High
Neurotransmitter 101 92.76 High High
corticosteroid 1 91.08 High High
tetrodotoxin 7 91.00 High High
Eae 17 90.04 High High
gABA 41 88.40 High High
Disease Link Frequency Relevance Heat
Stroke 76 99.76 Very High Very High Very High
Pain 2 88.24 High High
Stress 10 86.64 High High
Aids-related Complex 4 79.76 Quite High
Disease 36 79.52 Quite High
Vibrio Infection 1 68.68 Quite High
Generalized Anxiety Disorder 2 64.40 Quite High
Injury 14 64.00 Quite High
Neurological Disease 6 60.72 Quite High
Urological Neuroanatomy 7 53.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate a clear interaction between melatonin and 5-HT in the SCN, and suggest that melatonin and NPY may play similar roles with respect to modulating the phase of the SCN circadian pacemaker in rats.
SCN Spec (clear) Binding (interaction) of
1) Confidence 0.30 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082826 Disease Relevance 0 Pain Relevance 0.42
Due to a number of similarities in the actions of melatonin and NPY in the SCN, it seemed possible that melatonin and 5-HT might interact in the SCN as well.
SCN Spec (might) Binding (interact) of
2) Confidence 0.30 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082826 Disease Relevance 0 Pain Relevance 0.46
These results suggest that stroke may unmask interactions between the parietal/CPu locomotor rhythm generating system and other SCN-driven rhythms by yet unidentified mechanisms.
SCN Binding (interactions) of in parietal associated with stroke
3) Confidence 0.24 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.59 Pain Relevance 0.12
Integrated output as a result of integrated activity within the SCN in spite of heterogeneity in functional and neurochemical organization explains the efficiency of the SCN, the biological clock.
SCN Binding (efficiency) of
4) Confidence 0.23 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.06 Pain Relevance 0.34
Generalizations distilled from localization patterns of peptides first described have been applied to conceptually organize the SCN into a dichotomous structure.
SCN Binding (organize) of
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.06 Pain Relevance 0.09
SCN cell counting
SCN Binding (counting) of
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0
The organization of the mouse SCN, and its connections, are similar to that in other mammalian species.
SCN Binding (organization) of in SCN
7) Confidence 0.11 Published 2001 Journal Brain Res. Section Abstract Doc Link 11597605 Disease Relevance 0.07 Pain Relevance 0.24
Therefore, by integrating clock information from the SCN and the SPZ, the DMH plays a major role in regulating circadian sleep behavior.
SCN Binding (integrating) of
8) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701283 Disease Relevance 0 Pain Relevance 0.19
These findings reveal new complexities of SCN-TH interactions in the regulation of brain states and behavior.
SCN-TH Binding (interactions) of in brain
9) Confidence 0.09 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0 Pain Relevance 0.11
The Hb expresses receptors for neuropeptides associated with SCN efferents (Hernando et al., 2001; Cheng et al., 2006) as well as melatonin binding sites (Weaver et al., 1989), and retinal efferents arising from mRGCs innervate the LHb region (Hattar et al., 2006), indicating that photic and SCN-controlled output signals can regulate Hb cellular activity.
SCN Binding (associated) of associated with neuropeptide
10) Confidence 0.03 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0.17 Pain Relevance 0.17
Age alters the 24-h expression profile of CLOCK and its binding partner BMAL1 in the hamster SCN, but there is no effect of age on the 24-h profile of either Per1 or Per2 proteins when hamsters are housed in constant darkness.
SCN Binding (binding) of
11) Confidence 0.03 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.05 Pain Relevance 0
Addition of the ankyrinG-binding loop NavII-III therefore successfully targets ChR2-YFP to the AIS.
NavII-III Binding (binding) of
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966437 Disease Relevance 0 Pain Relevance 0
We targeted ChR2-YFP to the AIS by adding the Nav1.2 ankyrinG-binding loop NavII-III [84], [86] to its intracellular terminus.
NavII-III Binding (binding) of associated with nav1.2
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966437 Disease Relevance 0.08 Pain Relevance 0.17

General Comments

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