INT80736

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.32
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sptan1) plasma membrane (Sptan1) cytoskeleton (Sptan1)
protein complex (Sptan1) cytoplasm (Sptan1)
Anatomy Link Frequency
cleavage 1
lens 1
forebrain 1
Sptan1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 99.52 Very High Very High Very High
ischemia 24 99.30 Very High Very High Very High
Inflammation 4 94.12 High High
Spinal cord 6 88.48 High High
palliative 3 71.28 Quite High
anesthesia 2 25.00 Low Low
Central nervous system 13 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 170 99.68 Very High Very High Very High
Cv Unclassified Under Development 15 99.30 Very High Very High Very High
INFLAMMATION 4 94.84 High High
Death 43 94.64 High High
Paraplegia 5 89.92 High High
Pressure And Volume Under Development 9 88.92 High High
Spinal Cord Ischemia 5 88.48 High High
Stress 28 72.64 Quite High
Cataract 25 32.88 Quite Low
Cancer 3 11.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was neither detectable increase in a caspase-3-mediated breakdown product of alpha-fodrin, nor DNA laddering in any rabbit.
Protein_catabolism (breakdown) of alpha-fodrin
1) Confidence 0.32 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12598271 Disease Relevance 1.31 Pain Relevance 0.43
Calpain-induced proteolysis of fodrin was also extinguished by the calpain inhibitor in a dose-dependent manner.
Protein_catabolism (proteolysis) of fodrin
2) Confidence 0.25 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082855 Disease Relevance 0.51 Pain Relevance 0.28
Transient forebrain ischemia induces activation of calpain and proteolysis of a neuronal cytoskeleton, fodrin, in gerbil hippocampus.
Protein_catabolism (proteolysis) of fodrin in forebrain associated with ischemia and hippocampus
3) Confidence 0.25 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082855 Disease Relevance 0.44 Pain Relevance 0.18
Calpain-induced proteolysis of fodrin was also examined by immunohistochemistry and immunoblot.
Spec (examined) Protein_catabolism (proteolysis) of fodrin
4) Confidence 0.25 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082855 Disease Relevance 0.50 Pain Relevance 0.21
Fodrin/spectrin proteolysis could also be a possible event in this study in the development of lens opacification but the SDS-PAGE profile showed no significant change at the molecular range, which was expected for fodrin while the change was significant at a lower molecular range suggesting crystallin degradation as the major event in calpain degradation.
Protein_catabolism (proteolysis) of Fodrin in lens
5) Confidence 0.08 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.07 Pain Relevance 0
Thus there exists a possibility that like ion channels, AQPs are also anchored to the plasma membrane via fodrin and cleavage of fodrin during apoptosis renders the AQP non-functional.
Protein_catabolism (cleavage) of fodrin in cleavage associated with apoptosis
6) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.49 Pain Relevance 0

General Comments

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