INT80737

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Context Info
Confidence 0.12
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sptan1) plasma membrane (Sptan1) cytoskeleton (Sptan1)
protein complex (Sptan1) cytoplasm (Sptan1)
Anatomy Link Frequency
forebrain 2
neuronal 1
hippocampus 1
Sptan1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 15 99.98 Very High Very High Very High
Hippocampus 3 99.52 Very High Very High Very High
palliative 3 73.04 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 12 99.98 Very High Very High Very High
Death 9 94.64 High High
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient forebrain ischemia induces activation of calpain and proteolysis of a neuronal cytoskeleton, fodrin, in gerbil hippocampus.
Positive_regulation (activation) of in hippocampus Protein_catabolism (proteolysis) of fodrin in forebrain associated with ischemia and hippocampus
1) Confidence 0.12 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082855 Disease Relevance 0.44 Pain Relevance 0.18
Transient forebrain ischemia induces activation of calpain and proteolysis of a neuronal cytoskeleton, fodrin, in gerbil hippocampus.
Positive_regulation (induces) of in neuronal Protein_catabolism (proteolysis) of fodrin in forebrain associated with ischemia and hippocampus
2) Confidence 0.12 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082855 Disease Relevance 0.44 Pain Relevance 0.18
Calpain-induced proteolysis of fodrin was also extinguished by the calpain inhibitor in a dose-dependent manner.
Positive_regulation (extinguished) of Protein_catabolism (proteolysis) of fodrin
3) Confidence 0.12 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082855 Disease Relevance 0.51 Pain Relevance 0.28

General Comments

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