INT80750

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.97
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
articular 1
plasma 1
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
Pain 4 99.92 Very High Very High Very High
Morphine 14 99.80 Very High Very High Very High
spinal inflammation 8 99.10 Very High Very High Very High
Antinociceptive 3 98.72 Very High Very High Very High
cytokine 13 98.30 Very High Very High Very High
Crohn's disease 2 98.02 Very High Very High Very High
Snapping jaw 7 97.76 Very High Very High Very High
analgesia 4 97.12 Very High Very High Very High
Inflammation 17 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 7 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Arthralgia 1 100.00 Very High Very High Very High
Low Back Pain 8 99.10 Very High Very High Very High
Disease 8 99.00 Very High Very High Very High
Toxicity 2 98.96 Very High Very High Very High
Ulcers 5 98.78 Very High Very High Very High
Duodenal Ulcer 8 97.80 Very High Very High Very High
Temporomandibular Joint Syndrome 7 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between IL-1beta and morphine: possible mechanism of the deficiency of morphine-induced analgesia in diabetic mice.
IL-1beta Binding (interaction) of associated with pain, diabetes mellitus, analgesia and morphine
1) Confidence 0.47 Published 2000 Journal Pain Section Title Doc Link 11113291 Disease Relevance 0.87 Pain Relevance 1.74
Previously, we generated an alpha2M derivative (alpha(2)-macroglobulin activated for cytokine binding; MAC) similar in structure to alpha(2)M conformational intermediates, which binds tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and inhibits endotoxin toxicity.
interleukin-1beta Binding (binds) of associated with toxicity, necrosis, cancer and cytokine
2) Confidence 0.47 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 1.19 Pain Relevance 0.56
IL-1beta etiologically correlated with joint pathology, whereas TGFbeta expression associated with IL-1beta down-regulation and improvement of articular pathology.
IL-1beta Binding (associated) of in articular
3) Confidence 0.36 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19587162 Disease Relevance 1.15 Pain Relevance 0.73
Previously, we generated an alpha2M derivative (alpha(2)-macroglobulin activated for cytokine binding; MAC) similar in structure to alpha(2)M conformational intermediates, which binds tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and inhibits endotoxin toxicity.
IL-1beta Binding (binds) of associated with toxicity, necrosis, cancer and cytokine
4) Confidence 0.36 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 1.20 Pain Relevance 0.56
Compounds 1-14 were not able to inhibit binding of labeled interleukin-1 beta to EL 4-6.1 murine cells, since they had no affinity for interleukin-1 beta receptors.
interleukin-1 beta Neg (no) Binding (affinity) of
5) Confidence 0.34 Published 1999 Journal Arzneimittelforschung Section Abstract Doc Link 10083983 Disease Relevance 0.08 Pain Relevance 0.54
OBJECTIVE: Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS.
interleukin-1beta Binding (associated) of associated with spinal inflammation, inflammatory bowel disease, crohn's disease, antagonist and disease
6) Confidence 0.06 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12468823 Disease Relevance 0.56 Pain Relevance 0.50
OBJECTIVE: Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS.
IL-1B Binding (associated) of associated with spinal inflammation, inflammatory bowel disease, crohn's disease, antagonist and disease
7) Confidence 0.06 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12468823 Disease Relevance 0.56 Pain Relevance 0.50
CONCLUSION: IL-1B-511 T allele is associated with H. pylori infection in non-cardiac gastric cancer in a Chinese population.
IL-1B-511 Binding (associated) of
8) Confidence 0.02 Published 2007 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17295877 Disease Relevance 0 Pain Relevance 0
The present study aimed to determine polymorphisms of IL-1B and IL-1 receptor antagonist (IL-1RN) genes and their association with H. pylori infection and gastroduodenal diseases in Chinese patients.
IL-1B Binding (association) of associated with antagonist, disease and infection
9) Confidence 0.02 Published 2007 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 17295877 Disease Relevance 0.89 Pain Relevance 0.23
Because gastric cancer and duodenal ulcer are mutually exclusive outcomes of Helicobacter pylori infection, we aimed to investigate possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer.
IL-1B Binding (associations) of associated with ulcers, duodenal ulcer, infection and stomach cancer
10) Confidence 0.01 Published 2005 Journal Int. J. Immunogenet. Section Abstract Doc Link 16164697 Disease Relevance 1.03 Pain Relevance 0.23
PURPOSE: The aim of this study was to investigate whether interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), or soluble IL-1 receptor II (sIL-1RII) in synovial fluid or plasma is associated with joint pain or signs of tissue destruction in patients with temporomandibular joint (TMJ) involvement of polyarthritides.
interleukin-1beta Binding (associated) of in plasma associated with pain, arthralgia, snapping jaw, antagonist and arthritis
11) Confidence 0.00 Published 2003 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 14586853 Disease Relevance 0.44 Pain Relevance 0.36

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