INT80754

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.78
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1)
plasma membrane (PRF1)
Anatomy Link Frequency
blood 1
cardiac myocytes 1
pore 1
T cells 1
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 57 100.00 Very High Very High Very High
chemokine 12 95.24 Very High Very High Very High
Inflammation 49 85.04 High High
spinal inflammation 46 72.56 Quite High
spondylitis 6 55.00 Quite High
Angina 2 51.36 Quite High
addiction 31 49.08 Quite Low
Action potential 72 28.32 Quite Low
sodium channel 9 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 78 99.84 Very High Very High Very High
Cancer 15 99.34 Very High Very High Very High
Apoptosis 11 98.60 Very High Very High Very High
Toxicity 3 95.36 Very High Very High Very High
Sprains And Strains 13 92.68 High High
INFLAMMATION 58 85.04 High High
Adhesions 1 80.16 Quite High
Myocardial Infarction 77 75.00 Quite High
Diffuse Scleroderma 4 75.00 Quite High
Injury 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells travel in our blood stream in a state of rest, but can be immediately activated to a) kill cancer cells by either cell contact or secretion of cytotoxic compounds such as perforin and granzyme, b) proliferate, and c) secrete substances that attract other cells into the site.
Localization (secretion) of perforin in blood associated with cancer
1) Confidence 0.78 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.18 Pain Relevance 0.04
Neutrophil apoptosis in relation to respiratory burst, cytotoxic activity in CD8 T cells, perforin and granzyme production and CD4+T cell cytokine secretion in CFS patients are potential topics for future investigations.
Localization (secretion) of perforin in T cells associated with chronic fatigue syndrome, apoptosis and cytokine
2) Confidence 0.68 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 1.12 Pain Relevance 0.14
These findings strongly suggest that the infiltrating killer cells recognized cardiac myocytes as target cells and directly damaged them by releasing perforin.
Localization (releasing) of perforin in cardiac myocytes
3) Confidence 0.44 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.65 Pain Relevance 0.05
Cells were then stained for their surface antigens CD28 and CD8 and, after permeabilization, with FITC-conjugated anti-perforin, anti-IFN-?
Localization (permeabilization) of perforin
4) Confidence 0.13 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.36 Pain Relevance 0.18
The peak amplitudes in response to P2 were normalized to the peak amplitudes at P1, plotted versus the duration of P1, and designated peak INa (P2/P1).
Localization (plotted) of P1
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0 Pain Relevance 0
The peak amplitudes in response to P2 were normalized to the peak amplitudes at P1, plotted versus the duration of P1, and designated peak INa (P2/P1).
Localization (plotted) of P1
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0 Pain Relevance 0
20 mV (P1) of variable duration ranging between 10 and 1000 ms was followed by a test pulse (P2) after a 30-ms step to ?
Localization (duration) of P1
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0 Pain Relevance 0
APOL1 contains a signal sequence (amino acid 1-27) and the secreted protein could be divided in three domains in relation with trypanolysis: a pore-forming domain, a membrane-addressing domain, and an SRA-interacting domain [116].
Localization (secreted) of pore-forming in pore
8) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.46 Pain Relevance 0

General Comments

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