INT80755

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 88
Total Number 88
Disease Relevance 53.68
Pain Relevance 17.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 10
B cells 6
monocytes 5
macrophages 3
dendritic cells 3
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 32 99.84 Very High Very High Very High
cytokine 640 99.76 Very High Very High Very High
tolerance 46 99.72 Very High Very High Very High
Arthritis 583 99.68 Very High Very High Very High
Inflammation 999 99.60 Very High Very High Very High
Angina 77 99.60 Very High Very High Very High
rheumatoid arthritis 412 99.44 Very High Very High Very High
chemokine 177 98.80 Very High Very High Very High
spastic colon 26 98.44 Very High Very High Very High
fibrosis 80 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 209 100.00 Very High Very High Very High
Cancer 599 99.98 Very High Very High Very High
Juvenile Chronic Polyarthritis 511 99.68 Very High Very High Very High
INFLAMMATION 1120 99.60 Very High Very High Very High
Syndrome 83 99.60 Very High Very High Very High
Rheumatoid Arthritis 424 99.44 Very High Very High Very High
Infection 331 99.38 Very High Very High Very High
Adenocarcinoma 630 99.24 Very High Very High Very High
Disease 365 98.96 Very High Very High Very High
Systemic Sclerosis 16 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Freshly isolated human islet ECs constitutively expressed CD86 (B7-2) and ICOS ligand but not CD80 (B7-1) or CD40 costimulatory molecules.
Neg (not) Gene_expression (expressed) of CD40 in ECs
1) Confidence 0.75 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18941200 Disease Relevance 0.47 Pain Relevance 0.09
Furthermore, human leukocyte antigen classes I and II, intercellular adhesion molecule-1, as well as costimulatory molecules B7-1, B7-2, and CD40, all of which are known not to be expressed in cardiac myocytes under normal conditions, were moderately to strongly expressed in cardiac myocytes.
Gene_expression (expressed) of CD40 in leukocyte associated with adhesions
2) Confidence 0.66 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.90 Pain Relevance 0.07
Furthermore, human leukocyte antigen classes I and II, intercellular adhesion molecule-1, as well as costimulatory molecules B7-1, B7-2, and CD40, all of which are known not to be expressed in cardiac myocytes under normal conditions, were moderately to strongly expressed in cardiac myocytes.
Neg (not) Gene_expression (expressed) of CD40 in leukocyte associated with adhesions
3) Confidence 0.66 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.90 Pain Relevance 0.07
EBV-positive HRS cells express EBNA1, key for viral genome replication, as well as LMP1 and LMP2a which mimic CD40 receptors and BCRs, respectively [47, 48].
Gene_expression (receptors) of CD40 associated with epstein-barr virus
4) Confidence 0.65 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2994062 Disease Relevance 2.20 Pain Relevance 0
This is the recently described expression of CD40 (the receptor for CD40 ligand) by fibroblasts and other mesenchymal cells [16]; the CD40 system is normally associated with induction of the immune response.
Gene_expression (expression) of CD40 in mesenchymal cells
5) Confidence 0.65 Published 2002 Journal Respir Res Section Body Doc Link PMC64807 Disease Relevance 1.21 Pain Relevance 0.56
The myeloid dendritic cells in CSF expressed higher levels of HLA-DR, CD86, CD80 and CD40 than those in blood, whereas expression of these molecules by plasmacytoid dendritic cells was equal in blood and CSF.
Gene_expression (expressed) of CD40 in blood
6) Confidence 0.64 Published 2001 Journal Brain Section Abstract Doc Link 11222448 Disease Relevance 1.01 Pain Relevance 0.43
Furthermore, this tumor expresses a key marker of interest, CD40, which is a candidate for tumor-specific vector targeting via current modalities.
Gene_expression (expresses) of CD40 associated with cancer
7) Confidence 0.60 Published 2005 Journal Leuk. Lymphoma Section Abstract Doc Link 16334907 Disease Relevance 1.59 Pain Relevance 0
Furthermore, this tumor expresses a key marker of interest, CD40, which is a candidate for tumor-specific vector targeting via current modalities.
Gene_expression (expresses) of CD40 associated with cancer
8) Confidence 0.60 Published 2005 Journal Leuk. Lymphoma Section Abstract Doc Link 16334907 Disease Relevance 1.61 Pain Relevance 0
Serum levels of MIF, MCP-1, IL-6, IL-10, and sCD40L were assayed by an enzyme-linked immunosorbent assay sandwich technique (R & D Systems, Minneapolis, MN, USA) in accordance with the manufacturer's recommendations.
Gene_expression (levels) of CD40
9) Confidence 0.58 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.26 Pain Relevance 0.23
Soluble CD40 expression may also be related to MMP-9 expression in atherosclerotic tissues.
Gene_expression (expression) of CD40 associated with atherosclerosis and metalloproteinase
10) Confidence 0.53 Published 2005 Journal Heart Vessels Section Abstract Doc Link 16314905 Disease Relevance 0.68 Pain Relevance 0.77
In addition to T cells, the platelet is a very rich source of CD40 ligand, and as such mesenchymal cell activation and stimulation may occur through platelet degranulation or immune activation, processes that can occur in the absence of acute inflammation [19].


Gene_expression (source) of CD40 in platelet associated with inflammation
11) Confidence 0.51 Published 2002 Journal Respir Res Section Body Doc Link PMC64807 Disease Relevance 1.09 Pain Relevance 0.56
In distinction to drug-free maturing dendritic cells, 2.5 micromol/L sulfasalazine upregulated the levels of CD14 and CD68 and downregulated the levels of CD40, CD80, and CD83 (for all CD markers, p<0.03 for difference between measurements in the absence and the presence of sulfasalazine).
Gene_expression (levels) of CD40 in dendritic cells
12) Confidence 0.49 Published 2001 Journal Croat. Med. J. Section Body Doc Link 11471196 Disease Relevance 0 Pain Relevance 0
In addition they found the expression of CD40 to be increased.
Gene_expression (expression) of CD40
13) Confidence 0.49 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.07 Pain Relevance 0.15
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Gene_expression (expression) of CD40 in CD86 associated with adhesions
14) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.33 Pain Relevance 0.08
Increased levels of pro-inflammatory cytokines (TNF and IL-6) and increased production of soluble CD40 ligand from activated platelets [15,16] are also thought to play an important role.
Gene_expression (production) of CD40 in platelets associated with inflammation and cytokine
15) Confidence 0.47 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.46 Pain Relevance 0.19
Indicated by distinct signals of CD68, CD40 and CRP, inflammation was present in 5/21 (24%), 3/21 (14%) and 2/21 (10%) of ISR cases.
Gene_expression (signals) of CD40 associated with inflammation and cardiovascular disease
16) Confidence 0.46 Published 2004 Journal J. Vasc. Res. Section Abstract Doc Link 15528935 Disease Relevance 1.95 Pain Relevance 0.24
CD40 is expressed on all APCs (including B cells) and its ligand (CD40L or CD154) is on activated CD4+ T-cells and on a subset of CD8+ T-cells and NK cells.
Gene_expression (expressed) of CD40 in T-cells
17) Confidence 0.46 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Both lipopolysaccharide (LPS) and proinflammatory cytokines induce the expression of CD40, vascular adhesion molecule-1 or intercellular adhesion molecule-1, and E-selectin on human brain microvessel endothelial cells [20-24].
Gene_expression (expression) of CD40 in endothelial cells associated with adhesions and cytokine
18) Confidence 0.45 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.83 Pain Relevance 0.33
Expression of CD40 on synovial monocytes, fibroblasts and dendritic cells in RA has been reported [29,30].
Gene_expression (Expression) of CD40 in dendritic cells associated with rheumatoid arthritis
19) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.50 Pain Relevance 0.64
Dysfunctional T cells appear to be provoked, at least in part, through inadequate stimulation by immature DC [99], lacking costimulatory molecule and CD40 ligand expression.
Neg (lacking) Gene_expression (expression) of CD40 in T cells
20) Confidence 0.42 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.63 Pain Relevance 0.11

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