INT80756

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 77
Total Number 117
Disease Relevance 46.68
Pain Relevance 11.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD86) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 83
T cells 8
leukocyte 4
ECs 3
B cells 3
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 291 100.00 Very High Very High Very High
tolerance 48 100.00 Very High Very High Very High
cytokine 647 99.50 Very High Very High Very High
Inflammation 886 98.52 Very High Very High Very High
abatacept 247 95.56 Very High Very High Very High
Potency 4 95.28 Very High Very High Very High
rheumatoid arthritis 353 95.08 Very High Very High Very High
psoriasis 10 93.84 High High
cINOD 146 93.20 High High
agonist 156 91.84 High High
Disease Link Frequency Relevance Heat
Adhesions 129 100.00 Very High Very High Very High
Infection 1394 99.38 Very High Very High Very High
Hookworm Infection 315 99.34 Very High Very High Very High
Cold Sores 1015 99.20 Very High Very High Very High
Photoallergic Dermatitis 195 99.02 Very High Very High Very High
Chronic Hepatitis 12 99.00 Very High Very High Very High
Helminth Infection 36 98.92 Very High Very High Very High
Skin Cancer 103 98.56 Very High Very High Very High
INFLAMMATION 1099 98.52 Very High Very High Very High
Disease 359 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, no relevant modulation of the CD86 expression was detected with or without irradiation and no cytotoxic effect was observed up to the highest test concentration.
Gene_expression (expression) of CD86 in CD86
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.09 Pain Relevance 0
On the other hand, KP alone (without irradiation) had no relevant effect on the CD86 expression or on the cell viability.
Gene_expression (expression) of CD86 in CD86
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.15 Pain Relevance 0.09
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Gene_expression (expression) of CD86 in CD86 associated with adhesions
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.33 Pain Relevance 0.08
OLQ, a photoallergenic feed additive and antibiotic, induced under radiation conditions a dose-related increase in CD86 expression (?
Gene_expression (expression) of CD86 in CD86
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.16 Pain Relevance 0.08
In contrast, a marked increase in CD86 expression was observed under those same conditions (Fig. 3C).
Gene_expression (expression) of CD86 in CD86
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0.07
A dose-related increase in CD86 expression (?
Gene_expression (expression) of CD86 in CD86
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.07 Pain Relevance 0
In another study, we could demonstrate that the presence of 33% dead cells induced the unspecific upregulation of the CD86 expression [18].
Gene_expression (expression) of CD86 in CD86
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.11 Pain Relevance 0
NI induced similar dose-dependent increases of the CD86 expression under both conditions and irradiation had no influence on its relatively weak cytotoxicity.
Gene_expression (expression) of CD86 in CD86
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.08 Pain Relevance 0
CPZ, a known photosensitizer with photoallergenic and phototoxic properties, was tested with and without irradiation and the induced modulation of CD86, CD83 and HLA-DR expressions as well as cell viability were measured by flow cytometry and compared 48 h after treatment.
Gene_expression (expressions) of CD86 in CD86
9) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0 Pain Relevance 0
The impact of irradiation on the chosen biomarkers (CD86, CD83 and HLA-DR) expression was examined.
Gene_expression (expression) of CD86 in CD86
10) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0
Dose-dependent increases in CD86 and HLA-DR (but not CD83) expression were observed at radiation doses >1 J/cm2 UVA.
Gene_expression (expression) of CD86 in CD86
11) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.28 Pain Relevance 0
In contrast, (i) CD86 expression was not affected by the chosen irradiation conditions, (ii) increased CD86 expression induced by allergens was independent of irradiation and (iii) no PBMDC activation was observed with the non-allergenic control.
Gene_expression (expression) of CD86 in CD86
12) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.34 Pain Relevance 0
The analysis of an extensive data pool over multiple projects, extensive time periods and different laboratory personnel revealed a very stable basal expression of CD86 among donors (n?
Gene_expression (expression) of CD86 in CD86
13) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.06 Pain Relevance 0
Using our assay, MA a known allergenic and photoallergenic fragrance [19], [26] induced a dose-related increase in CD86 expression with or without irradiation, the increase being significantly higher after irradiation.
Gene_expression (expression) of CD86 in CD86
14) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.15 Pain Relevance 0
Indeed, KP induced a dose-dependent increase of CD86 expression after irradiation whereas without irradiation it had no relevant effect on the CD86 expression or on the cell viability.
Gene_expression (expression) of CD86 in CD86
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.22 Pain Relevance 0.08
Indeed, KP induced a dose-dependent increase of CD86 expression after irradiation whereas without irradiation it had no relevant effect on the CD86 expression or on the cell viability.
Gene_expression (expression) of CD86 in CD86
16) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.21 Pain Relevance 0.08
This represents a very significant increase in CD86 expression compared to the low ?
Gene_expression (expression) of CD86 in CD86
17) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.06 Pain Relevance 0
In contrast, (i) CD86 expression was not affected by the chosen irradiation conditions, (ii) increased CD86 expression induced by allergens was independent of irradiation and (iii) no PBMDC activation was observed with the non-allergenic control.
Gene_expression (expression) of CD86 in CD86
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.36 Pain Relevance 0
The magnitude of that variability was investigated by measuring the expression of CD86, CD83 and HLA-DR on non-irradiated and irradiated, immature PBMDCs.
Gene_expression (expression) of CD86 in CD86
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0
Using our test protocol, the photoallergenic feed additive OLQ induced significant and dose-related increases in CD86 expression and cytotoxicity was detected at the highest test concentration.
Gene_expression (expression) of CD86 in CD86
20) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.15 Pain Relevance 0.07

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