INT80760

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.73
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPV5) transmembrane transport (TRPV5)
Anatomy Link Frequency
transporting cells 1
intestinal epithelium 1
embryonic kidney 1
oocytes 1
TRPV5 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 2 92.72 High High
member 8 1 75.00 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 6 95.24 Very High Very High Very High
Kidney Stones 8 88.92 High High
Colon Cancer 4 85.08 High High
Apoptosis 1 43.68 Quite Low
Genetic Predisposition To Disease 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Renal Insufficiency 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we explored the mechanism of dietary protection by hCa by analyzing the expression of genes involved in the regulation of Ca uptake/flux in the intestinal epithelium, including the Ca-sensing receptor, vitamin D receptor, Ca binding protein, and transient receptor potential cation channels, subfamily V, members 5 and 6 (TRPV5/6).
Spec (analyzing) Gene_expression (expression) of TRPV5 in intestinal epithelium
1) Confidence 0.75 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20508153 Disease Relevance 0.64 Pain Relevance 0.07
Wild-type and TRPV5 channels including polymorphisms were transiently expressed in human embryonic kidney (HEK) 293 cells and functionally characterized by path-clamp analysis.
Gene_expression (expressed) of TRPV5 in embryonic kidney
2) Confidence 0.60 Published 2009 Journal Nephrol. Dial. Transplant. Section Body Doc Link 19131347 Disease Relevance 0.09 Pain Relevance 0
ECaC expression in Xenopus oocytes confers Ca2+ influx with properties identical to those observed in distal renal cells.
Gene_expression (expression) of ECaC in oocytes
3) Confidence 0.38 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10085067 Disease Relevance 0 Pain Relevance 0.09
In kidney, ECaC is abundantly present in the apical membrane of Ca2+ transporting cells and colocalizes with 1,25-dihydroxyvitamin D3-dependent calbindin-D28K.
Gene_expression (present) of ECaC in transporting cells
4) Confidence 0.33 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10085067 Disease Relevance 0 Pain Relevance 0.09

General Comments

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