INT80798

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 7.95
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Chd7) helicase activity (Chd7) DNA binding (Chd7)
Anatomy Link Frequency
liver 4
muscles 1
brain 1
Chd7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 135 99.84 Very High Very High Very High
Paracetamol 22 99.20 Very High Very High Very High
rheumatoid arthritis 69 97.96 Very High Very High Very High
cytokine 38 94.20 High High
transdermal 63 90.48 High High
Inflammatory stimuli 4 89.68 High High
anesthesia 2 84.88 Quite High
Bile 1 77.04 Quite High
chemokine 16 64.80 Quite High
Infliximab 54 54.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 131 99.84 Very High Very High Very High
Stress 55 99.44 Very High Very High Very High
Hepatotoxicity 16 98.96 Very High Very High Very High
Rheumatoid Arthritis 127 98.92 Very High Very High Very High
Injury 49 97.92 Very High Very High Very High
Cardiovascular Disease 17 97.64 Very High Very High Very High
Disease 144 97.60 Very High Very High Very High
Shock 36 97.08 Very High Very High Very High
Endometriosis (extended) 37 96.40 Very High Very High Very High
Coagulation Disorder 14 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zinc pretreatment, a method of MT induction, protected against acetaminophen hepatotoxicity in control mice, but not in MT-null mice.
Positive_regulation (induction) of MT associated with paracetamol and hepatotoxicity
1) Confidence 0.14 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087053 Disease Relevance 0.70 Pain Relevance 0.93
True evidence exists for the beneficial effect of treating RA to a target of LDA in a structured strategic way when compared with non-structured therapy.28 29 However, the Expert Committee felt that, while being an important step and a major alternative goal, reaching LDA could only pertain to patients with long-standing RA whose disease may have become refractory to therapeutic intervention.
Positive_regulation (reaching) of LDA associated with rheumatoid arthritis and disease
2) Confidence 0.14 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015099 Disease Relevance 0.51 Pain Relevance 0.21
Treatment with L1, on the other hand, had no effect on liver or kidney copper and MT, but resulted in increased brain copper and MT levels.
Positive_regulation (increased) of MT in liver
3) Confidence 0.13 Published 2002 Journal J. Inorg. Biochem. Section Abstract Doc Link 11803042 Disease Relevance 0.33 Pain Relevance 0.06
induction of MT can protect animals from hepatotoxicity of several chemicals,
Positive_regulation (induction) of MT associated with hepatotoxicity
4) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 1.31 Pain Relevance 0.17
We report that hepatic, renal and brain copper and MT are elevated in TX mice at 3 and 12 months of age.
Positive_regulation (elevated) of MT in brain
5) Confidence 0.11 Published 2002 Journal J. Inorg. Biochem. Section Abstract Doc Link 11803042 Disease Relevance 0.49 Pain Relevance 0.08
In MT+/+ mice infected with H. pylori, liver MT was increased by 33 and 39% (p <.05) at 8 and 16 weeks, respectively, whereas gastric MT increased by 46% (p <.05) at 4 weeks and declined to baseline levels at 8 and 16 weeks.
Positive_regulation (increased) of MT in liver
6) Confidence 0.10 Published 2003 Journal Helicobacter Section Body Doc Link 14536000 Disease Relevance 0.06 Pain Relevance 0
In MT+/+ mice infected with H. pylori, liver MT was increased by 33 and 39% (p <.05) at 8 and 16 weeks, respectively, whereas gastric MT increased by 46% (p <.05) at 4 weeks and declined to baseline levels at 8 and 16 weeks.
Positive_regulation (increased) of MT in liver
7) Confidence 0.10 Published 2003 Journal Helicobacter Section Body Doc Link 14536000 Disease Relevance 0.06 Pain Relevance 0
as MT are produced mainly in the liver, indicating a possible role of MT in the
Spec (possible) Positive_regulation (role) of MT in liver
8) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 1.33 Pain Relevance 0.10
studies have demonstrated that MT is induced by oxidative stress-producing
Positive_regulation (induced) of MT associated with stress
9) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.53 Pain Relevance 0.06
In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied.
Positive_regulation (induced) of MT associated with stress and inflammation
10) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2679981 Disease Relevance 0.91 Pain Relevance 0.22
The induction of MT is known as one of important biological activities of zinc, a PZ subcomponent.
Positive_regulation (induction) of MT
11) Confidence 0.07 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.12 Pain Relevance 0
levels after LPS challenge, it is suggested that MT induction is not involved in the protective effect of PZ on LPS-induced endotoxin shock in our experimental model.
Positive_regulation (induction) of MT associated with shock
12) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.35 Pain Relevance 0.05
The action of LDA can be compactly written as,(6)(7)
Positive_regulation (action) of LDA
13) Confidence 0.04 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2903603 Disease Relevance 0 Pain Relevance 0
The submental muscles showed the highest SEMG activation (LDA, 25.42; RDA, 26.06).
Positive_regulation (activation) of LDA in muscles
14) Confidence 0.03 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
Thus, DAS28 at RRR-study entry had the most marked correlation with the maintenance of LDA for 1 year after the discontinuation.
Positive_regulation (maintenance) of LDA associated with rheumatoid arthritis
15) Confidence 0.02 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015067 Disease Relevance 0.81 Pain Relevance 0.03
In addition, as a result of HERS, HERS II, and the WHI, HT is no longer recommended solely for the prevention of cardiovascular disease in post-menopausal women (ACOG 2004; Nelson et al 2005; NAMS 2007).
Positive_regulation (result) of WHI associated with endometriosis (extended) and cardiovascular disease
16) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761184 Disease Relevance 0.43 Pain Relevance 0.05
There was a significant association between ST ICT and MT IBT positivity rates and increasing IFA IgM titers (ST ICT and MT IBT Pearson's ?
Positive_regulation (increasing) of MT IBT
17) Confidence 0.01 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox