INT80806

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.34
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDC) nucleus (PDC) cilium (PDC)
cytoplasm (PDC)
PDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 35 99.68 Very High Very High Very High
mu opioid receptor 7 98.36 Very High Very High Very High
opioid receptor 25 98.32 Very High Very High Very High
Central nervous system 9 98.32 Very High Very High Very High
Enkephalin 15 97.64 Very High Very High Very High
cytokine 21 97.04 Very High Very High Very High
Immobilon 8 97.04 Very High Very High Very High
Morphine 2 94.32 High High
ASIC 5 89.04 High High
Multiple sclerosis 19 86.72 High High
Disease Link Frequency Relevance Heat
Cerebral Palsy 7 100.00 Very High Very High Very High
Psoriasis 80 99.52 Very High Very High Very High
Disease 54 99.52 Very High Very High Very High
Multiple Sclerosis 5 95.84 Very High Very High Very High
Demyelinating Disease 20 86.72 High High
Neurological Disease 5 84.72 Quite High
Movement Disorders 1 80.36 Quite High
Dystonia 2 78.64 Quite High
INFLAMMATION 52 76.92 Quite High
Infection 5 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, coexpression of both phosducin and beta-arrestin 1 reverses this blockade.
Gene_expression (coexpression) of phosducin
1) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10443588 Disease Relevance 0 Pain Relevance 0.55
In contrast, Phd overexpressing cells largely failed to respond to the opioid.
Gene_expression (overexpressing) of Phd associated with opioid
2) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.92
Thus, in Phd overexpressing cells, opioids exhibit an increased efficacy despite the inhibitory action of the phosphoprotein on opioid-stimulated incorporation of [35S]guanosine-5'-O-(gamma-thio)-triphosphate.
Gene_expression (overexpressing) of Phd associated with opioid
3) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.94
Control cells and cells overexpressing Phd were transiently transfected to express mu-opioid receptors fused to green fluorescence protein.
Gene_expression (overexpressing) of Phd associated with mu opioid receptor
4) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.73
Experience with the PHD was not permitted.
Gene_expression (Experience) of PHD
5) Confidence 0.56 Published 2008 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2699064 Disease Relevance 0 Pain Relevance 0
Studying the binding of [35S]guanosine-5'-O-(gamma-thio)-triphosphate to membranes from Phd overexpressing cells, we found that [D-penicillamine2, D-penicillamine5 ]enkephalin failed, in the presence of Phd (0.1 nM), to elevate incorporation of the nucleotide.
Gene_expression (overexpressing) of Phd associated with enkephalin
6) Confidence 0.46 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.52
In controls and in Phd overexpressing cells confocal microscopy identified fluorescence associated with the membrane.
Gene_expression (overexpressing) of Phd
7) Confidence 0.46 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.80
Thus, pDC depletion significantly enhances the activation of CNS cells and the production of cytokines such as IL-17 and IFN-?
Gene_expression (depletion) of pDC associated with central nervous system and cytokine
8) Confidence 0.33 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.56 Pain Relevance 0.31
In humans, infiltration of pDC and expression of IFN-?
Gene_expression (expression) of pDC
9) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.81 Pain Relevance 0.28
In contrast, pDC are almost absent in chronic psoriatic lesions.
Neg (absent) Gene_expression (absent) of pDC associated with psoriasis
10) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.97 Pain Relevance 0.33
Therefore, although the ASIC4 gene is physically mapped to the PDC locus, our data indicates that ASIC4 gene mutation is not the cause of PDC.
Gene_expression (mapped) of PDC associated with cerebral palsy
11) Confidence 0.28 Published 2001 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 11571555 Disease Relevance 1.00 Pain Relevance 0.26
(FV, female, 25, PhD student)
Gene_expression (student) of PhD
12) Confidence 0.04 Published 2010 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2946266 Disease Relevance 0 Pain Relevance 0.08

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