INT80808

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.13
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDC) nucleus (PDC) cilium (PDC)
cytoplasm (PDC)
PDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 16 100.00 Very High Very High Very High
cytokine 6 100.00 Very High Very High Very High
Opioid 28 99.68 Very High Very High Very High
mu opioid receptor 4 99.52 Very High Very High Very High
opioid receptor 16 98.32 Very High Very High Very High
Immobilon 4 97.04 Very High Very High Very High
Enkephalin 12 88.92 High High
Multiple sclerosis 38 86.72 High High
Inflammation 16 76.92 Quite High
headache 2 30.80 Quite Low
Disease Link Frequency Relevance Heat
Disease 28 99.52 Very High Very High Very High
Multiple Sclerosis 10 95.84 Very High Very High Very High
Demyelinating Disease 40 86.72 High High
Neurological Disease 6 77.80 Quite High
INFLAMMATION 16 76.92 Quite High
Infection 8 76.00 Quite High
Recurrence 16 64.48 Quite High
Headache 2 30.80 Quite Low
Injury 2 30.44 Quite Low
Normal Pressure Hydrocephalus 2 29.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control cells and cells overexpressing Phd were transiently transfected to express mu-opioid receptors fused to green fluorescence protein.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Phd associated with mu opioid receptor
1) Confidence 0.53 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.73
In contrast, Phd overexpressing cells largely failed to respond to the opioid.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Phd associated with opioid
2) Confidence 0.38 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.92
Thus, in Phd overexpressing cells, opioids exhibit an increased efficacy despite the inhibitory action of the phosphoprotein on opioid-stimulated incorporation of [35S]guanosine-5'-O-(gamma-thio)-triphosphate.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Phd associated with opioid
3) Confidence 0.38 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.94
Control cells and cells overexpressing Phd were transiently transfected to express mu-opioid receptors fused to green fluorescence protein.
Positive_regulation (transfected) of Gene_expression (overexpressing) of Phd associated with mu opioid receptor
4) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.74
Thus, pDC depletion significantly enhances the activation of CNS cells and the production of cytokines such as IL-17 and IFN-?
Positive_regulation (enhances) of Gene_expression (depletion) of pDC associated with central nervous system and cytokine
5) Confidence 0.24 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.56 Pain Relevance 0.31
Thus, pDC depletion significantly enhances the activation of CNS cells and the production of cytokines such as IL-17 and IFN-?
Positive_regulation (as) of Gene_expression (depletion) of pDC associated with central nervous system and cytokine
6) Confidence 0.24 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.57 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox