INT80809

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Context Info
Confidence 0.28
First Reported 1999
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.71
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (STMN1) signal transduction (STMN1) cytoskeleton (STMN1)
intracellular (STMN1) cytoplasm (STMN1) signal transducer activity (STMN1)
Anatomy Link Frequency
nerve 2
neuronal 1
astrocytes 1
optic nerve 1
STMN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 65 100.00 Very High Very High Very High
Enkephalin 3 97.72 Very High Very High Very High
Opioid 7 94.44 High High
opioid receptor 4 94.12 High High
Inflammation 11 92.36 High High
Central nervous system 28 88.88 High High
agonist 12 50.00 Quite Low
mu opioid receptor 1 46.88 Quite Low
Immobilon 1 27.36 Quite Low
anesthesia 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 89 99.98 Very High Very High Very High
Glaucoma 364 99.96 Very High Very High Very High
Familial Adenomatous Polyposis 16 97.40 Very High Very High Very High
Cancer 130 96.24 Very High Very High Very High
Ganglion Cysts 92 94.76 High High
INFLAMMATION 9 92.36 High High
Borna Disease 4 82.92 Quite High
Neurological Disease 4 80.52 Quite High
Infection 29 75.80 Quite High
Disease 22 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the prelaminar optic nerve head, low levels of STMN were expressed in the glial columns and in the nerve bundles in both control and ExpG samples without obvious differences (Figure 4C, D).
Neg (without) Gene_expression (expressed) of STMN in nerve associated with glaucoma
1) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 1.03 Pain Relevance 0
In both control and ExpG, STMN expression was absent from the lamina cribrosa and present in the optic nerve proper.
Neg (absent) Gene_expression (expression) of STMN in optic nerve associated with glaucoma
2) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.99 Pain Relevance 0
In ExpG, STMN was detected in the nerve fiber layer and in few GFAP-negative process-bearing cells.
Gene_expression (detected) of STMN in nerve associated with glaucoma
3) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 1.02 Pain Relevance 0
STMN was not expressed in GFAP+ astrocytes in the myelinated nerve.
Neg (not) Gene_expression (expressed) of STMN in astrocytes
4) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.79 Pain Relevance 0
of the expression of proteins with oncogenic and antioxidant functions

(stathmin 1, DJ-1 protein, peroxiredoxin 2, nucleoside diphosphate kinase A, etc.) in

Gene_expression (expression) of stathmin 1
5) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.94 Pain Relevance 0.03
of the expression of proteins with oncogenic and antioxidant functions

(stathmin 1, DJ-1 protein, peroxiredoxin 2, nucleoside diphosphate kinase A, etc.) in

Gene_expression (expression) of stathmin 1
6) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.94 Pain Relevance 0.03
Here, we tested the hypothesis that BDV phosphoprotein (P) may serve as a PKC decoy substrate when expressed in neurons, resulting in an interference with PKC-dependent signaling and impaired neuronal activity.
Gene_expression (expressed) of phosphoprotein in neuronal associated with virus diseases and kinase c
7) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 1.01 Pain Relevance 0.48
NG 108-15 hybrid cells stably expressing the phosphoprotein were challenged with [D-penicillamine2,D-penicillamine5]enkephalin to inhibit cAMP generation, demonstrating an increased efficacy of the opioid on AC.
Gene_expression (expressing) of phosphoprotein associated with enkephalin and opioid
8) Confidence 0.00 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087055 Disease Relevance 0 Pain Relevance 0.44

General Comments

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