INT80837

Context Info Confidence 0.42 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.11 Pain Relevance 2.02

RNA binding (NOVA2) nucleus (NOVA2)

Anatomy Link Frequency parietal cortex 1 liver 1 NOVA2 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 5 99.84 nerve block 10 98.36 Cholecystokinin 7 96.56 addiction 2 88.24 agonist 1 81.44 Clonidine 2 80.80 Mcgill questionnaire 1 80.64 imagery 29 78.84 Somatostatin 3 75.04 qutenza 11 73.00

Disease Link Frequency Relevance Heat Pain 6 99.84 Necrosis 108 97.88 Hepatotoxicity 17 93.16 Urological Neuroanatomy 18 92.04 Death 8 89.00 Targeted Disruption 24 78.16 Fatigue 21 70.40 Hypoxia 93 65.68 Injury 27 65.12 Cancer 5 50.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If variance was not found to be homogeneous, ANOVA was replaced by the Welch's test.

Negative_regulation (replaced) of ANOVA

1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.13 Pain Relevance 0

However, the ANOVA does suggest that, on the night of surgery, there was a significant reduction in pain as measured with the VAS in the FNB group.

Negative_regulation (reduction) of ANOVA associated with nerve block and pain

2) Confidence 0.08 Published 2000 Journal Arthroscopy Section Abstract Doc Link 10750003 Disease Relevance 0.49 Pain Relevance 1.17

There was, however, a statistically significant difference in parietal cortex neuronal counts among the four cohorts (ANOVA p?

Negative_regulation (difference) of ANOVA in parietal cortex

3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.22 Pain Relevance 0

However, at 1 mM and 10 mM, the intensity values decreased dramatically in wild type animals, suggesting significant reduction in the fluid access (ANOVA, F5, 34?

Negative_regulation (reduction) of ANOVA

4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.27 Pain Relevance 0.37

We then leveraged ANOVA pairwise contrasts of the severity groups and GoMiner analysis of the gene expression data to subset the samples into groups with similar phenotypic changes exhibited by necrosis of the liver and comparable overrepresentation of biological processes (Figure 1).

Negative_regulation (leveraged) of ANOVA in liver associated with hepatotoxicity

5) Confidence 0.02 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.93 Pain Relevance 0

Gastrin levels were decreased on day 1, 3 and 10 (ANOVA; p < 0.01).

Negative_regulation (decreased) of ANOVA

6) Confidence 0.02 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10087452 Disease Relevance 0 Pain Relevance 0.48

At a 10-min ITI, the jump response declines significantly slower than that at a 1-min ITI (two-way ANOVA, ITI effect p < 0.001).

Negative_regulation (declines) of ANOVA

7) Confidence 0.02 Published 2007 Journal Journal of Neurogenetics Section Body Doc Link PMC2409173 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.