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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
hypothalamus 2
gonadal 2
neurons 2
pituitary 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 99.76 Very High Very High Very High
narcan 5 99.72 Very High Very High Very High
opiate 2 91.04 High High
antagonist 1 90.40 High High
withdrawal 1 80.00 Quite High
medulla 1 76.64 Quite High
anesthesia 4 75.20 Quite High
ketamine 3 75.00 Quite High
Neuropeptide 2 75.00 Quite High
Endogenous opioid 1 67.44 Quite High
Disease Link Frequency Relevance Heat
Hypothermia 1 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This facilitatory, modulating effect at the pituitary level involves an allosteric increase in LHRH binding to its receptor leading to augmented influx of Ca2+ from the extracellular space.
Positive_regulation (increase) of LHRH Binding (binding) of in pituitary
1) Confidence 0.67 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.17
Previous studies on the mediobasal hypothalamus (MBH) of rats, rhesus monkeys and goats have detected episodic increases in multiunit activity (MUA volleys) which immediately precede a pulse of luteinizing hormone (LH).
Positive_regulation (precede) of luteinizing hormone Binding (pulse) of in hypothalamus
2) Confidence 0.41 Published 1999 Journal Brain Res. Section Abstract Doc Link 10547003 Disease Relevance 0 Pain Relevance 0.19
Pentobarbital stimulates the activity of the GnRH pulse generator interacting with opioid neurons in rats in proestrus.
Positive_regulation (stimulates) of GnRH Binding (interacting) of in neurons associated with narcan and opioid
3) Confidence 0.40 Published 2000 Journal Psychoneuroendocrinology Section Title Doc Link 10737698 Disease Relevance 0 Pain Relevance 0.38
The feedback signals provided by gonadal steroids can induce both inhibition and facilitation of LHRH and LH secretion.
Positive_regulation (induce) of LHRH Neg (inhibition) Binding (inhibition) of in gonadal
4) Confidence 0.12 Published 1986 Journal J. Steroid Biochem. Section Abstract Doc Link 3100869 Disease Relevance 0 Pain Relevance 0.17

General Comments

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