INT8087

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 2.41
Pain Relevance 6.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
brainstem 6
outflow 4
hypothalamus 4
nucleus 2
external 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 47 100.00 Very High Very High Very High
narcan 13 100.00 Very High Very High Very High
Cannabinoid 11 100.00 Very High Very High Very High
anesthesia 1 100.00 Very High Very High Very High
Clonidine 9 99.82 Very High Very High Very High
antagonist 11 99.38 Very High Very High Very High
noradrenaline 18 99.24 Very High Very High Very High
Peripheral nerve injury 2 98.96 Very High Very High Very High
agonist 8 98.88 Very High Very High Very High
fluoxetine 7 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 3 100.00 Very High Very High Very High
Injury 5 99.82 Very High Very High Very High
Neuropathic Pain 6 99.64 Very High Very High Very High
Hypoglycemia 6 99.60 Very High Very High Very High
Nervous System Injury 10 98.52 Very High Very High Very High
Neuroma 3 95.16 Very High Very High Very High
Pain 1 93.36 High High
Obesity 4 90.28 High High
Urological Neuroanatomy 2 88.24 High High
Hyperphagia 1 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, we studied the effects of iv saline (controls) or NAL infusion (2 mg/h) between 1100-1400 h on NPY concentrations in seven microdissected sites in the medial basal hypothalamus (MBH) and preoptic area in association with the increase in the rate of LH secretion, and then we examined the effects of NAL on the in vitro release of NPY and LHRH from the MBH of E2-primed ovx rats.
Spec (examined) Regulation (effects) of Localization (release) of NPY in hypothalamus associated with narcan
1) Confidence 0.45 Published 1990 Journal Endocrinology Section Abstract Doc Link 2404749 Disease Relevance 0.15 Pain Relevance 0.51
There is evidence that gonadal steroids regulate NPY neurosecretion in a site-specific manner, and that alterations in NPY secretion may occur in part via a direct action of the steroids on NPY neurons in the brainstem and hypothalamus and in part through an indirect effect involving removal of the inhibitory influence of endogenous opioid peptides.
Regulation (regulate) of Localization (neurosecretion) of NPY in brainstem associated with medulla and endogenous opioid
2) Confidence 0.44 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.17
In the present investigation we studied the effect of North African Androctonus australis garzonii scorpion toxin on neuropeptide Y (NPY) release from rat atria and kidneys by a perifusion system in vitro.
Regulation (effect) of Localization (release) of NPY associated with neuropeptide
3) Confidence 0.30 Published 2009 Journal Peptides Section Abstract Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.52
We examined the effect of cannabinoids on NPY release using a rat hypothalamic explant model.
Spec (examined) Regulation (effect) of Localization (release) of NPY associated with cannabinoid
4) Confidence 0.27 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15949823 Disease Relevance 0 Pain Relevance 0.56
The effect of the alpha 2-adrenoceptor agonist clonidine, the antagonists prazosin (alpha 1 selective) and yohimbine (alpha 2 selective) and the beta-adrenoceptor antagonist propranolol were all shown to modulate the evoked release of NPY.
Regulation (modulate) of Localization (release) of NPY associated with antagonist, agonist and clonidine
5) Confidence 0.27 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8413845 Disease Relevance 0 Pain Relevance 0.52
Fluoxetine also significantly reduced neuropeptide Y levels in the paraventricular nucleus, a major site of neuropeptide Y release which is highly sensitive to the appetite-stimulating actions of neuropeptide Y.
Regulation (sensitive) of Localization (release) of neuropeptide Y in nucleus associated with neuropeptide and fluoxetine
6) Confidence 0.27 Published 1996 Journal Neuroscience Section Abstract Doc Link 8737424 Disease Relevance 0.47 Pain Relevance 1.04
Injury-related alterations in the regulatory activities of NPY released within the DRG at somally-distributed Y-receptors may also contribute to the development and/or persistence of symptoms characteristic of sympathetically-maintained pain.
Regulation (alterations) of Localization (released) of NPY in DRG associated with pain and injury
7) Confidence 0.27 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.55 Pain Relevance 0.31
There is evidence that gonadal steroids regulate NPY neurosecretion in a site-specific manner, and that alterations in NPY secretion may occur in part via a direct action of the steroids on NPY neurons in the brainstem and hypothalamus and in part through an indirect effect involving removal of the inhibitory influence of endogenous opioid peptides.
Regulation (alterations) of Localization (secretion) of NPY in brainstem associated with medulla and endogenous opioid
8) Confidence 0.27 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.18
To elucidate the potential role of NPY in the endocrine pancreas, we studied the expression and regulation of NPY secretion in a rat insulinoma cell line (INS-1).
Regulation (regulation) of Localization (secretion) of NPY in endocrine pancreas associated with hypoglycemia
9) Confidence 0.26 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.10 Pain Relevance 0.08
In conclusion, 1) high levels of gene expression and secretion of NPY are found in a rat insulinoma cell line (INS-1). 2) Accumulation of cAMP induced by forskolin or a gluco-incretin (GLP-1) induces a further increase in NPY gene expression and release. 3) NPY secretion is not modulated by low or high glucose concentrations in the medium. 4) Induction of NPY, a known inhibitor of insulin secretion, may represent a novel counterregulatory mechanism of insulin secretion, limiting the stimulatory effect of GLP-1 on insulin secretion.
Regulation (modulated) of Localization (secretion) of NPY associated with hypoglycemia
10) Confidence 0.26 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.16 Pain Relevance 0.17
Incubation of INS-1 cells with various glucose concentrations did not modify NPY secretion; however, stimulation of adenylate cyclase by forskolin induced a dose- and time-dependent increase in NPY release in the medium.
Neg (not) Regulation (modify) of Localization (secretion) of NPY
11) Confidence 0.26 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.15 Pain Relevance 0.17
Yohimbine, did not modify the release of ir-NPY but increased the NA outflow, it antagonized the clonidine effect.
Neg (not) Regulation (modify) of Localization (release) of NPY in outflow associated with noradrenaline and clonidine
12) Confidence 0.26 Published 2002 Journal Peptides Section Abstract Doc Link 12217427 Disease Relevance 0 Pain Relevance 0.62
Clonidine did not affect the release of ir-NPY while it lowered the outflow of NA, not altering the rise in perfusion pressure elicited by the electrical stimuli.
Neg (not) Regulation (affect) of Localization (release) of NPY in outflow associated with noradrenaline and clonidine
13) Confidence 0.26 Published 2002 Journal Peptides Section Abstract Doc Link 12217427 Disease Relevance 0 Pain Relevance 0.62
Effect of food deprivation and streptozotocin-induced diabetes on hypothalamic neuropeptide Y release as measured by a radioimmunoassay-linked microdialysis procedure.
Regulation (Effect) of Localization (release) of neuropeptide Y associated with anesthesia, diabetes mellitus and neuropeptide
14) Confidence 0.24 Published 1994 Journal Brain Res. Section Title Doc Link 7804826 Disease Relevance 0.24 Pain Relevance 0.20
The effect of conduction block on the spinal release of immunoreactive-neuropeptide Y (ir-NPY) in the neuropathic rat.
Regulation (effect) of Localization (release) of ir-NPY in spinal associated with neuropathic pain and neuropeptide
15) Confidence 0.24 Published 2001 Journal Pain Section Title Doc Link 11275379 Disease Relevance 0.60 Pain Relevance 0.45
Differential effects of peptide YY, neuropeptide Y, and sigma ligands on neurally stimulated external pancreatic secretion in the rat.
Regulation (effects) of Localization (secretion) of neuropeptide Y in external associated with neuropeptide
16) Confidence 0.24 Published 1995 Journal Pancreas Section Title Doc Link 7716135 Disease Relevance 0 Pain Relevance 0.33
There is evidence that gonadal steroids regulate NPY neurosecretion in a site-specific manner, and that alterations in NPY secretion may occur in part via a direct action of the steroids on NPY neurons in the brainstem and hypothalamus and in part through an indirect effect involving removal of the inhibitory influence of endogenous opioid peptides.
Regulation (regulate) of in hypothalamus Localization (neurosecretion) of NPY in brainstem associated with medulla and endogenous opioid
17) Confidence 0.15 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.17
There is evidence that gonadal steroids regulate NPY neurosecretion in a site-specific manner, and that alterations in NPY secretion may occur in part via a direct action of the steroids on NPY neurons in the brainstem and hypothalamus and in part through an indirect effect involving removal of the inhibitory influence of endogenous opioid peptides.
Regulation (alterations) of in hypothalamus Localization (secretion) of NPY in brainstem associated with medulla and endogenous opioid
18) Confidence 0.09 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.18

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