INT80873

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Context Info
Confidence 0.01
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Nfkb1, Nfkbia) cytoplasm (Nfkb1, Nfkbia) cytosol (Nfkb1, Nfkbia)
nucleus (Nfkb1, Nfkbia) mitochondrion (Nfkb1) enzyme binding (Nfkbia)
Nfkb1 (Rattus norvegicus)
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 3 95.12 Very High Very High Very High
rheumatoid arthritis 5 50.00 Quite Low
Inflammation 3 50.00 Quite Low
cytokine 2 50.00 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Acute pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 88.76 High High
Cancer 1 88.40 High High
INFLAMMATION 4 85.80 High High
Adhesions 2 80.04 Quite High
Rheumatoid Arthritis 5 79.92 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because activation of NF-kappaB requires proteolytic degradation of IkappaB by the ubiquitin-proteasome pathway of intracellular proteolysis, treatment with proteasome inhibitors was evaluated for efficacy in preventing NSAID gastropathy.
Positive_regulation (activation) of NF-kappaB Positive_regulation (requires) of Protein_catabolism (degradation) of IkappaB associated with cinod
1) Confidence 0.01 Published 1999 Journal Gastroenterology Section Abstract Doc Link 10092308 Disease Relevance 0.42 Pain Relevance 0.27
NF-kappaB activation was detected using Western blotting to follow degradation of IkappaBalpha and nuclear localization of the p65 subunit of NF-kappaB.
Positive_regulation (activation) of NF-kappaB Positive_regulation (follow) of Protein_catabolism (degradation) of IkappaBalpha
2) Confidence 0.00 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347944 Disease Relevance 0.16 Pain Relevance 0

General Comments

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