INT80883

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 18
Disease Relevance 1.03
Pain Relevance 13.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
neuronal 2
SH-SY5Y 2
embryonic kidney 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 860 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
agonist 95 99.98 Very High Very High Very High
Enkephalin 56 99.98 Very High Very High Very High
substance P 5 99.96 Very High Very High Very High
Morphine 46 99.90 Very High Very High Very High
Kinase C 16 98.76 Very High Very High Very High
antagonist 229 98.70 Very High Very High Very High
MU agonist 13 98.58 Very High Very High Very High
potassium channel 30 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 98.88 Very High Very High Very High
Bordatella Infection 1 83.92 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

90 77.84 Quite High
Nociception 43 69.96 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

192 66.52 Quite High
Pain 66 33.52 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Colitis 6 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine and DAMGO enhanced MOR1 phosphorylation over basal.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of MOR1 associated with morphine
1) Confidence 0.69 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.59
Protein kinase C can phosphorylate the receptor, but is not involved in DAMGO-induced MOR1TAG phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR1TAG associated with kinase c
2) Confidence 0.54 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0.09 Pain Relevance 0.69
The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist, opioid receptor and enkephalin
3) Confidence 0.54 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10092593 Disease Relevance 0.09 Pain Relevance 0.85
DAMGO stimulated a threefold increase in MOR1 phosphorylation within 20 min that could be reversed by the antagonist naloxone.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of MOR1 associated with antagonist, narcan and opioid receptor
4) Confidence 0.53 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.68
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Positive_regulation (induced) of Phosphorylation (osphorylation a) of MOR1 associated with enkephalin
5) Confidence 0.50 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.30
However, exposure of the sst(2A)-MOR1 heterodimer to the sst(2A)-selective ligand L-779,976 induced phosphorylation, internalization, and desensitization of sst(2A) as well as MOR1.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR1
6) Confidence 0.50 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.31
The ability of two opioid agonists, [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) and morphine, to induce mu-opioid receptor (MOR) phosphorylation, desensitization, and internalization was examined in human embryonic kidney (HEK) 293 cells expressing rat MOR1 as well G protein-coupled inwardly rectifying potassium channel (GIRK) channel subunits.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of mu-opioid receptor in embryonic kidney associated with mu agonist, potassium channel, opioid receptor, enkephalin and morphine
7) Confidence 0.47 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 0.94
However, in MOR/ mGluR5 co-expressing cells, the non-competitive mGluR5 antagonist MPEP (2-methyl-6-(phenyl-ethynyl)-pyridine) decreases the DAMGO-induced MOR phosphorylation, internalization, and desensitization, whereas non-selective competitive mGluR antagonists or agonists had no effects.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR associated with antagonist, agonist and opioid receptor
8) Confidence 0.43 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.02
DAMGO stimulated a threefold increase in MOR1 phosphorylation within 20 min that could be reversed by the antagonist naloxone.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MOR1 associated with antagonist, narcan and opioid receptor
9) Confidence 0.36 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.67
Calyculin A increased the magnitude of MOR1TAG phosphorylation without altering the DAMGO-induced loss of the adenylyl cyclase response.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of MOR1TAG
10) Confidence 0.31 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0.07 Pain Relevance 0.67
Conversely, exposure of the NK1-MOR1 heterodimer to the NK1-selective ligand substance P (SP) promoted cross-phosphorylation and cointernalization of the MOR1 receptor.
Positive_regulation (promoted) of Phosphorylation (phosphorylation) of MOR1 associated with opioid receptor and substance p
11) Confidence 0.27 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.07 Pain Relevance 0.85
Further, exposure of SKNMCs to Na2S caused the direct phosphorylation of MOR in the Ser(377) (Figure 5, panel C), a measure of the receptor activation, and exposure of cells to DAMGO also caused a robust induction of MOR phosphorylation in the serine residue, thought that the kinetic of the two effects was different (Figure 5, panel C).
Positive_regulation (caused) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor
12) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.07 Pain Relevance 0.68
Further, exposure of SKNMCs to Na2S caused the direct phosphorylation of MOR in the Ser(377) (Figure 5, panel C), a measure of the receptor activation, and exposure of cells to DAMGO also caused a robust induction of MOR phosphorylation in the serine residue, thought that the kinetic of the two effects was different (Figure 5, panel C).
Positive_regulation (induction) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor
13) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.06 Pain Relevance 0.64
Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cells.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Mu-opioid receptor in SH-SY5Y associated with neuroblastoma, narcan and opioid receptor
14) Confidence 0.10 Published 2005 Journal Neurosignals Section Title Doc Link 16088228 Disease Relevance 0.28 Pain Relevance 0.35
Moreover, glibenclamide inhibits both MOR and AKT phosphorylation induced by hydrogen sulphide, demonstrating that activation of ATP potassium channels by hydrogen sulphide is a key process of these effects.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR associated with potassium channel and opioid receptor
15) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.89
DAMGO-induced MOR phosphorylation occurs at Thre (370) and Ser(375) [Ser(377) in human receptor] but only mutation of Ser(375) is reported to attenuate the rate and extent of receptor internalization [38].
Positive_regulation (-) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor
16) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.70
DAMGO-induced MOR phosphorylation occurs at Thre (370) and Ser(375) [Ser(377) in human receptor] but only mutation of Ser(375) is reported to attenuate the rate and extent of receptor internalization [38].
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MOR associated with opioid receptor
17) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.70
receptor-selective enkephalin analog DAMGO and H2S confirm these data demonstrating that, in the neuronal-cell line SKNMC, both DAMGO and H2S induce MOR activation and phosphorylation leading to interaction between MOR and ?
Positive_regulation (leading) of Phosphorylation (phosphorylation) of MOR in neuronal associated with opioid receptor and enkephalin
18) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 1.12

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