INT80885

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB2) cytoplasmic membrane-bounded vesicle (ARRB2) plasma membrane (ARRB2)
nucleus (ARRB2) cytoplasm (ARRB2)
ARRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 98.40 Very High Very High Very High
agonist 107 95.84 Very High Very High Very High
Opioid 6 92.40 High High
Pain 2 90.12 High High
opioid receptor 4 76.84 Quite High
Enkephalin 4 75.00 Quite High
adenocard 60 64.00 Quite High
Kinase C 2 63.52 Quite High
narcan 1 62.80 Quite High
antagonist 18 62.44 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 3 98.88 Very High Very High Very High
Death 8 97.96 Very High Very High Very High
Pain 2 90.12 High High
Cancer 13 87.92 High High
Apoptosis 4 57.84 Quite High
Ischemic Heart Disease 1 56.08 Quite High
INFLAMMATION 4 53.92 Quite High
Asthma 1 52.80 Quite High
Neuroblastoma 5 52.48 Quite High
Pulmonary Disease 1 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arrestin 2 and arrestin 3 were able to reduce the cAMP production upon stimulation of endogenous A2BR by NECA and stimulation of ?
Positive_regulation (upon) of Gene_expression (Arrestin 2) of arrestin 3
1) Confidence 0.49 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.27 Pain Relevance 0.15
Suppression of endogenous beta-arrestin2 by specific RNA interfering (RNAi) and morphine treatment significantly attenuates the levels of phosphorylated Akt compared with inhibition of beta-arrestin2 or morphine treatment alone.
Positive_regulation (Suppression) of Gene_expression (Suppression) of beta-arrestin2 associated with morphine
2) Confidence 0.35 Published 2009 Journal Neoplasma Section Abstract Doc Link 19239323 Disease Relevance 1.04 Pain Relevance 1.14
However, in the same cell lines under the same conditions, overexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 accelerated the rate of DPDPE- but not DAMGO-induced receptor desensitization.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta-arrestin 2
3) Confidence 0.26 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0.05 Pain Relevance 0.53

General Comments

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