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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.76
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
cardiomyocytes 1
leukocyte 1
superior 1
paw 1
Hmox2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 5 99.80 Very High Very High Very High
cINOD 34 99.78 Very High Very High Very High
Hippocampus 2 98.84 Very High Very High Very High
Central nervous system 1 98.40 Very High Very High Very High
Spinal cord 5 98.16 Very High Very High Very High
spinal inflammation 58 97.88 Very High Very High Very High
Inflammation 26 97.74 Very High Very High Very High
Analgesic 3 97.56 Very High Very High Very High
Osteoarthritis 2 96.88 Very High Very High Very High
Pain 15 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 100.00 Very High Very High Very High
INFLAMMATION 36 99.66 Very High Very High Very High
Ulcers 3 99.58 Very High Very High Very High
Nociception 6 99.08 Very High Very High Very High
Low Back Pain 63 97.88 Very High Very High Very High
Cancer 5 97.24 Very High Very High Very High
Necrosis 5 96.96 Very High Very High Very High
Injury 4 96.96 Very High Very High Very High
Osteoarthritis 2 96.88 Very High Very High Very High
Rheumatoid Arthritis 10 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice with a targeted disruption of the HO-2 gene were found to have greatly reduced licking times.
Negative_regulation (disruption) of HO-2 gene associated with targeted disruption
1) Confidence 0.55 Published 2000 Journal Pain Section Abstract Doc Link 10779663 Disease Relevance 0.51 Pain Relevance 0.24
BACKGROUND: The cyclo-oxygenase-2 inhibitor, parecoxib, can be administered parenterally.
Negative_regulation (inhibitor) of cyclo-oxygenase-2
2) Confidence 0.36 Published 2006 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 16923101 Disease Relevance 0 Pain Relevance 0.24
LTP is normal in mice that lack HO-2 and, furthermore, there is no obvious mechanism by which HO could be activated during synaptic stimulation.
Negative_regulation (lack) of HO-2
3) Confidence 0.23 Published 1998 Journal Essays Biochem. Section Abstract Doc Link 10488443 Disease Relevance 0.09 Pain Relevance 0.15
The present immunohistochemical study details localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in lumbar spinal cord before and after induction of a painful paw inflammation in mice.
Negative_regulation (details) of cyclo-oxygenase-1 and -2 in paw associated with pain, inflammation, spinal cord and neuronal nitric oxide synthase
4) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.26 Pain Relevance 0.49
Meloxicam [4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine -3-carboxamide-1, 1-dioxide] is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class which shows preferential inhibition of cyclo-oxygenase-2.
Negative_regulation (inhibition) of cyclo-oxygenase-2 associated with inflammation and cinod
5) Confidence 0.06 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10092958 Disease Relevance 0.37 Pain Relevance 0.31
In comparison to traditional nonsteroidal anti-inflammatory drugs, specific cyclo-oxygenase-2 inhibitors may provide equal efficacy in terms of antiinflammatory and analgesic action, with significantly fewer gastrointestinal side effects.
Negative_regulation (inhibitors) of cyclo-oxygenase-2 associated with inflammation, analgesic and cinod
6) Confidence 0.04 Published 2000 Journal Curr Opin Anaesthesiol Section Abstract Doc Link 17016362 Disease Relevance 0.39 Pain Relevance 0.29
In line with this concept, neither cyclo-oxygenase-1 nor cyclo-oxygenase-2 deficient mice develop spontaneous gastrointestinal ulcers and pharmacological inhibition of cyclo-oxygenase-1 or cyclo-oxygenase-2 with selective inhibitors doesn't elicit gastrointestinal damage; suggesting that both isoforms of cyclo-oxygenase enzymes have to be inhibited to induce ulcers.
Negative_regulation (inhibition) of cyclo-oxygenase-2 associated with ulcers
7) Confidence 0.02 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827361 Disease Relevance 1.10 Pain Relevance 0.42
This compound exerted acute and chronic anti-inflammatory effects by oral route, that may be related with several mechanisms such as attenuation of leukocyte activation, inhibition of inducible nitric oxide synthase, cyclo-oxygenase-2 and cytosolic phospholipase A(2) expression as well as reduction in tumour necrosis factor-alpha production.
Negative_regulation (inhibition) of cyclo-oxygenase-2 in leukocyte associated with necrosis, inflammation and cancer
8) Confidence 0.01 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12732367 Disease Relevance 0.53 Pain Relevance 0.31
One particular NSAID, which is a highly selective cyclo-oxygenase 2 inhibitor, etoricoxib, may be superior to standard NSAIDs for AS.
Negative_regulation (inhibitor) of cyclo-oxygenase 2 in superior associated with spinal inflammation and cinod
9) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2387283 Disease Relevance 1.05 Pain Relevance 1.05
These findings indicate that the antiphlogistic action of cyclo-oxygenase-2 inhibition may provide a friendly protection to ischemic cardiomyocytes.
Negative_regulation (inhibition) of cyclo-oxygenase-2 in cardiomyocytes
10) Confidence 0.00 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 17126650 Disease Relevance 0.38 Pain Relevance 0.13

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