INT8091

Context Info Confidence 0.27 First Reported 1987 Last Reported 1992 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.21

extracellular space (Npy) extracellular region (Npy)

Anatomy Link Frequency gonadal 2 brain 2 Npy (Rattus norvegicus) LH (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neurotransmitter 1 96.94 Neuropeptide 4 88.24 antagonist 6 43.52 opiate 2 42.00 agonist 2 40.72 dopamine receptor 1 25.00 Endogenous opioid 1 25.00 Morphine 1 25.00 medulla 1 25.00

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Protein

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Event

Anatomy

Negation

Speculation

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Because adrenergic neurotransmitters, norepinephrine (NE) and epinephrine (E), show intraneuronal coexistence with NPY in certain brain regions of the rat and there are similarities in the effects of NPY and NE/E on LH release, we investigated the possible interaction of NPY and adrenergic receptor systems in the stimulation of LH release in EBP-treated ovariectomized rats.

NPY Regulation (effects) of Localization (release) of LH in brain associated with neurotransmitter

1) Confidence 0.27 Published 1987 Journal Endocrinology Section Abstract Doc Link 2824175 Disease Relevance 0 Pain Relevance 0.13

The stimulatory effect of NPY on LH secretion is dependent upon the presence of gonadal hormones and involves amplification of the response of other interacting stimulatory signals.

NPY Regulation (effect) of Localization (secretion) of LH in gonadal

2) Confidence 0.18 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.08

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