INT80923

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.78
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
lateral 4
cerebellum 3
cerebral cortex 2
caudate-putamen 2
medial 1
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 85 100.00 Very High Very High Very High
cerebral cortex 12 98.28 Very High Very High Very High
Potency 1 94.00 High High
Substantia nigra 18 91.20 High High
Endocannabinoid 35 90.36 High High
agonist 8 83.44 Quite High
Cannabinoid 13 74.76 Quite High
tolerance 12 68.04 Quite High
Analgesic 6 25.00 Low Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 137 98.64 Very High Very High Very High
Diabetes Mellitus 29 78.44 Quite High
Disorder Of Lipid Metabolism 7 32.12 Quite Low
Insulin Resistance 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Dyslipidemia /

Combined Dyslipidemia

1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Endometriosis (extended) 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the SAT of OBT2D subjects might be characterized by a relatively decreased activity of CB1 receptors, and strongly increased activity of PPAR?
Negative_regulation (activity) of CB1 Binding (receptors) of associated with obesity
1) Confidence 0.19 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 0.78 Pain Relevance 0.28
As expected, the exposure to delta 9-THC for 5 d resulted in a decrease of cannabinoid receptor binding in the molecular layer of the cerebellum, medial, and lateral caudate-putamen and, in particular, entopeduncular nucleus.
Negative_regulation (decrease) of cannabinoid receptor Binding (binding) of in lateral associated with cannabinoid receptor
2) Confidence 0.16 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 10096037 Disease Relevance 0 Pain Relevance 0.61
We also found decreased cannabinoid receptor binding in the superficial and deep layers of the cerebral cortex, two regions used as a reference to test the specificity of changes observed in motor areas.
Negative_regulation (decreased) of cannabinoid receptor Binding (binding) of in cerebral cortex associated with cannabinoid receptor and cerebral cortex
3) Confidence 0.14 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 10096037 Disease Relevance 0 Pain Relevance 0.61
The chronic exposure to delta 9-THC also resulted in decreased cannabinoid receptor binding in the cerebellum, although without affecting mRNA expression.
Negative_regulation (decreased) of cannabinoid receptor Binding (binding) of in cerebellum associated with cannabinoid receptor
4) Confidence 0.14 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 10096037 Disease Relevance 0 Pain Relevance 0.35
In summary, the chronic exposure to delta 9-THC resulted in a decrease in cannabinoid receptor binding and mRNA levels in the caudate-putamen, where cell bodies of cannabinoid receptor-containing neurons in the basal ganglia are located.
Negative_regulation (decrease) of cannabinoid receptor Binding (binding) of in caudate-putamen associated with cannabinoid receptor
5) Confidence 0.10 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 10096037 Disease Relevance 0 Pain Relevance 0.53
As expected, the exposure to delta 9-THC for 5 d resulted in a decrease of cannabinoid receptor binding in the molecular layer of the cerebellum, medial, and lateral caudate-putamen and, in particular, entopeduncular nucleus.
Negative_regulation (decrease) of cannabinoid receptor in medial Binding (binding) of in lateral associated with cannabinoid receptor
6) Confidence 0.05 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 10096037 Disease Relevance 0 Pain Relevance 0.61
As expected, the exposure to delta 9-THC for 5 d resulted in a decrease of cannabinoid receptor binding in the molecular layer of the cerebellum, medial, and lateral caudate-putamen and, in particular, entopeduncular nucleus.
Negative_regulation (decrease) of cannabinoid receptor in cerebellum Binding (binding) of in lateral associated with cannabinoid receptor
7) Confidence 0.05 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 10096037 Disease Relevance 0 Pain Relevance 0.61

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