INT80926

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.85
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HTR4) plasma membrane (HTR4) cytoplasm (HTR4)
signal transducer activity (HTR4)
Anatomy Link Frequency
brain 1
gut 1
HTR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 13 100.00 Very High Very High Very High
Neurotransmitter 3 99.26 Very High Very High Very High
Inflammation 2 97.36 Very High Very High Very High
spastic colon 15 97.12 Very High Very High Very High
antagonist 14 90.64 High High
Analgesic 6 85.24 High High
biopsychosocial 2 82.64 Quite High
tricyclic antidepressant 2 76.40 Quite High
abdominal pain 2 75.68 Quite High
agonist 28 73.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 97.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 97.12 Very High Very High Very High
Infection 2 96.80 Very High Very High Very High
Disease 3 88.96 High High
Abdominal Pain 2 75.68 Quite High
Functional Bowel Disorder 5 75.00 Quite High
Pain 4 72.72 Quite High
Diarrhoea 2 53.60 Quite High
Dyspepsia 2 50.00 Quite Low
Constipation 2 44.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Numerous neurotransmitters are found in the brain and gut that regulate GI activities, including 5-hydroxytryptamine (5-HT, serotonin) and its 5-HT3 and 5-HT4 receptors.
Regulation (regulate) of 5-HT4 in gut associated with neurotransmitter and serotonin
1) Confidence 0.60 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173682 Disease Relevance 0.63 Pain Relevance 0.94
In the current study, in vitro studies were conducted in order to determine the affinity of (+/-)-SM 21 for serotonin 5-HT3, 5-HT4, and sigma receptors.
Spec (determine) Regulation (affinity) of 5-HT4 associated with serotonin
2) Confidence 0.44 Published 1999 Journal Life Sci. Section Abstract Doc Link 10096443 Disease Relevance 0 Pain Relevance 0.26
AIM: In this study, we evaluated the efficacy of H2-receptor antagonist (famotidine) and 5-HT4 receptor agonist (mosapride citrate).
Regulation (efficacy) of 5-HT4
3) Confidence 0.26 Published 2005 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15943846 Disease Relevance 0 Pain Relevance 0
Numerous neurotransmitters are found in the brain and gut that regulate GI activities, including 5-hydroxytryptamine (5-HT, serotonin) and its 5-HT3 and 5-HT4 receptors.
Regulation (regulate) of 5-HT4 in brain associated with neurotransmitter and serotonin
4) Confidence 0.20 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173682 Disease Relevance 0.63 Pain Relevance 0.94
The D100A mutation in the mouse 5-HT4 receptor converts it into a RASSL [22], but its effects on the human 5-HT4 receptor have not been tested.
Regulation (effects) of 5-HT4
5) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.22

General Comments

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