INT8095

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Context Info
Confidence 0.77
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 47
Total Number 50
Disease Relevance 24.85
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
plasma membrane (ERBB3) nucleus (ERBB3)
Anatomy Link Frequency
MDA-MB-231 17
MCF-7 6
MDA-MB-468 2
hepatocyte 1
exocrine pancreas 1
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 15 99.84 Very High Very High Very High
metalloproteinase 35 99.60 Very High Very High Very High
Glutamate 5 97.96 Very High Very High Very High
Chronic pancreatitis 6 97.72 Very High Very High Very High
Dismenorea 3 97.28 Very High Very High Very High
cINOD 68 97.12 Very High Very High Very High
COX-2 inhibitor 289 94.56 High High
methotrexate 4 88.96 High High
imagery 66 81.32 Quite High
withdrawal 6 79.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 1256 100.00 Very High Very High Very High
Breast Cancer 717 100.00 Very High Very High Very High
Apoptosis 1289 99.92 Very High Very High Very High
Endometriosis 24 99.84 Very High Very High Very High
Disease 88 99.70 Very High Very High Very High
Anaplastic Astrocytoma 280 99.40 Very High Very High Very High
Carcinoma 31 98.92 Very High Very High Very High
Adenocarcinoma 20 98.36 Very High Very High Very High
Glioblastoma 85 97.72 Very High Very High Very High
Pancreatitis 6 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer.
Gene_expression (expressed) of erbB-3 associated with cancer
1) Confidence 0.77 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1361525 Disease Relevance 0.53 Pain Relevance 0.09
In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis.
Gene_expression (overexpression) of erbB-3 protein in exocrine pancreas associated with carcinoma and chronic pancreatitis
2) Confidence 0.77 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1361525 Disease Relevance 0.54 Pain Relevance 0.10
Using immunohistochemical techniques, we studied the expression of c-erb B-2 in normal human endometrial tissue (n = 8), endometriosis interna (adenomyosis) (n = 8) and endometriosis externa (endometriotic cyst of the ovary) (n = 6).
Gene_expression (expression) of c-erb B-2 in ovary associated with endometriosis, dismenorea and cyst
3) Confidence 0.67 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 7650146 Disease Relevance 0.70 Pain Relevance 0.30
Immunohistochemical study of c-erb B-2 protein expression in endometriosis.
Gene_expression (expression) of c-erb B-2 associated with endometriosis
4) Confidence 0.67 Published 1995 Journal Hum. Reprod. Section Title Doc Link 7650146 Disease Relevance 0.73 Pain Relevance 0.32
Most of the cases of endometriosis studied showed no expression of c-erb B-2 in glandular epithelium.
Neg (no) Gene_expression (expression) of c-erb B-2 in epithelium associated with endometriosis
5) Confidence 0.67 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 7650146 Disease Relevance 0.72 Pain Relevance 0.31
The overexpression of c-erbB3 and c-erbB4 is in accordance with our previous study on glioblastomas as well as with others [8,21,54,59,60].
Gene_expression (overexpression) of c-erbB3 associated with glioblastoma
6) Confidence 0.63 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.88 Pain Relevance 0
The list of correspondingly important up-regulated genes in NHEK was extensive and included activin A, transglutaminase 2 (TGM2), ErbB3 (HER3), matrix metalloproteinase 9 (MMP-9), fibronectin (FN!)
Gene_expression (included) of ErbB3 associated with metalloproteinase
7) Confidence 0.63 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0.12
Cancer cells expressing EGFR and ErbB2 are nonresponsive to inhibitors targeting one of these two proteins.63 Similarly, overexpression of ErbB3 also confers resistance to EGFR inhibitors.64 Expression of hepatocyte growth factor and c-Met dependent signaling is also an alternative pathway for signaling conferring resistance (seen in approximately 20% of patients with acquired resistance to TKIs).65 Finally, interactions between EGFR and the insulin growth factor receptor (IGF-1R) can provide resistance to agents targeting EGFR.66
Gene_expression (overexpression) of ErbB3 in hepatocyte associated with cancer
8) Confidence 0.56 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.36 Pain Relevance 0
Due to overexpression of the c-erbB1-4 receptor proteins and their location on the surface of neoplastic astrocytes, they are attractive candidates for targeted therapy [11-13].
Gene_expression (overexpression) of c-erbB1 in astrocytes
9) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.85 Pain Relevance 0
Formalin-fixed and paraffin-embedded sections from 31 cases were investigated by standard immunohistochemical procedures for expression of c-erbB1-4 receptor proteins using commercial antibodies.
Spec (investigated) Gene_expression (expression) of c-erbB1
10) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2859381 Disease Relevance 0.23 Pain Relevance 0
Multiple Cox regression analysis with overall survival as the dependent variable was performed for clinical disease features with expression of c-erbB1-4 and EGFR gene amplification (Table 4).
Gene_expression (expression) of c-erbB1 associated with disease
11) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.62 Pain Relevance 0
Expression of c-erbB1-4 receptor proteins was determined by immunohistochemistry using various commercial monoclonal antibodies listed in Table 1.
Gene_expression (Expression) of c-erbB1
12) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.31 Pain Relevance 0.18
The aim of this study was to investigate EGFR gene amplification and expression of c-erbB1-4 receptor proteins in human anaplastic astrocytomas.
Gene_expression (expression) of c-erbB1 associated with anaplastic astrocytoma
13) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2859381 Disease Relevance 0.19 Pain Relevance 0
We have analysed, by immunocytochemistry using the 21N antibody, expression of c-erb B-2 in a retrospective series of pancreatic adenocarcinoma, chronic pancreatitis, and examples of histologically normal pancreas.
Gene_expression (expression) of c-erb B-2 in pancreas associated with adenocarcinoma and chronic pancreatitis
14) Confidence 0.55 Published 1990 Journal J. Pathol. Section Abstract Doc Link 2202801 Disease Relevance 0.60 Pain Relevance 0.18
These data suggest that there is abnormal expression of c-erb B-2 oncogene in nearly 20 per cent of cases although mutational activation of this gene is not seen in human pancreatic adenocarcinoma.
Gene_expression (expression) of c-erb B-2 associated with adenocarcinoma
15) Confidence 0.55 Published 1990 Journal J. Pathol. Section Abstract Doc Link 2202801 Disease Relevance 0.47 Pain Relevance 0.11
The list of correspondingly important up-regulated genes in NHEK was extensive and included activin A, transglutaminase 2 (TGM2), ErbB3 (HER3), matrix metalloproteinase 9 (MMP-9), fibronectin (FN!)
Gene_expression (included) of HER3 associated with metalloproteinase
16) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0.12
By forming heterodimers with other members of the EGFR family, c-erbB3 channels erbB signaling through the PI3K/Akt pathway which in turn promotes tumor growth and progression.
Gene_expression (channels) of c-erbB3 associated with cancer
17) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.75 Pain Relevance 0
Neither overexpression of EGFR, c-erbB3, and c-erbB4, nor EGFR gene amplification reached significance.


Gene_expression (overexpression) of c-erbB3
18) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2859381 Disease Relevance 0.67 Pain Relevance 0
The erbB family of growth tyrosine kinase receptors comprises four structurally homologous members including erbB1, also known as the epidermal growth factor receptor (EGFR), erbB2 (HER2/neu), erbB3 (HER3) and erbB4 (HER4) (Yarden and Sliwkowski 2001).
Gene_expression (neu) of erbB3
19) Confidence 0.44 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936363 Disease Relevance 0.60 Pain Relevance 0.06
The erbB family of growth tyrosine kinase receptors comprises four structurally homologous members including erbB1, also known as the epidermal growth factor receptor (EGFR), erbB2 (HER2/neu), erbB3 (HER3) and erbB4 (HER4) (Yarden and Sliwkowski 2001).
Gene_expression (neu) of HER3
20) Confidence 0.44 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936363 Disease Relevance 0.60 Pain Relevance 0.07

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