INT8096

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 13.43
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
thyroid 4
tears 2
plasma 2
epithelial cell 2
HGF 2
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 246 100.00 Very High Very High Very High
palliative 11 98.48 Very High Very High Very High
cytokine 85 98.00 Very High Very High Very High
interstitial cystitis 10 94.84 High High
metalloproteinase 22 94.72 High High
chemokine 24 90.00 High High
Inflammation 65 89.00 High High
withdrawal 3 88.64 High High
Nerve growth factor 18 88.20 High High
Inflammatory mediators 6 80.20 Quite High
Disease Link Frequency Relevance Heat
Solid Tumor 11 99.64 Very High Very High Very High
Eye Disease 65 99.42 Very High Very High Very High
Cancer 268 99.08 Very High Very High Very High
Breast Cancer 54 99.00 Very High Very High Very High
Reprotox - General 1 200 98.92 Very High Very High Very High
Non-small-cell Lung Cancer 6 98.80 Very High Very High Very High
Colon Cancer 6 98.64 Very High Very High Very High
Malignant Neoplastic Disease 12 97.68 Very High Very High Very High
Pancreatic Cancer 8 97.56 Very High Very High Very High
Capsule Opacification 57 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of EGF receptor protein decreased following each cycle of androgen ablation and increased subsequently after androgen supplementation.
Positive_regulation (increased) of Gene_expression (expression) of EGF
1) Confidence 0.69 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0.06 Pain Relevance 0
There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGF
2) Confidence 0.67 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1361525 Disease Relevance 0.49 Pain Relevance 0.07
Overexpression of the epidermal growth factor receptor (EGFR) has been reported as an important molecular abnormality in human pancreatic cancer.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of epidermal growth factor associated with pancreatic cancer
3) Confidence 0.66 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.36 Pain Relevance 0.12
Alternatively, other ligands and receptors of the EGF system may become overexpressed during prolonged withdrawal and supplementation of androgenic hormones in prostate cancer therapy.


Spec (may) Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGF
4) Confidence 0.50 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0 Pain Relevance 0
Prostate cancer cells generated during intermittent androgen ablation acquire a growth advantage and exhibit changes in epidermal growth factor receptor expression.
Positive_regulation (changes) of Gene_expression (expression) of epidermal growth factor associated with reprotox - general 1
5) Confidence 0.50 Published 2004 Journal Prostate Section Title Doc Link 15065088 Disease Relevance 0.19 Pain Relevance 0.14
Furthermore, EGF-R-overexpression as well as increased m-RNA levels of TGF-?
Positive_regulation (increased) of Gene_expression (overexpression) of EGF-R
6) Confidence 0.48 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.84 Pain Relevance 0
Upregulation of EGF/EGFR expression has been reported in metastatic PCa [30].
Positive_regulation (Upregulation) of Gene_expression (expression) of EGF associated with reprotox - general 1
7) Confidence 0.47 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.59 Pain Relevance 0.12
Moreover, increased EGF expression also has been confirmed in human PCa in vivo [22].
Positive_regulation (increased) of Gene_expression (expression) of EGF associated with reprotox - general 1
8) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.88 Pain Relevance 0.54
The effect of EGF (exogenous and endogenous) in increasing VGSC protein expression was also apparent in plasma membrane (PM).
Positive_regulation (increasing) of Gene_expression (expression) of EGF in plasma associated with sodium channel
9) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.69
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
Positive_regulation (increased) of Gene_expression (levels) of EGF in epithelial cell associated with cystitis and interstitial cystitis
10) Confidence 0.43 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 1.13 Pain Relevance 0.46
, one of the seven known ligands of EGF-R, are overexpressed in many solid tumours, including colorectal cancer, NSCLC, and HNSCC [5].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGF-R associated with non-small-cell lung cancer, colon cancer and solid tumor
11) Confidence 0.34 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.90 Pain Relevance 0
Our study revealed that tears from mild-to-moderate DED patients have significantly increased levels of EGF, fractalkine/CX3CL1, IL-1Ra, IP10/CXCL-10, IL-8/CXCL8, and VEGF.
Positive_regulation (increased) of Gene_expression (levels) of EGF in tears associated with eye disease
12) Confidence 0.27 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.30 Pain Relevance 0.40
Overexpression of the EGF receptor (EGFR), a transmembrane 170-kDa glycoprotein tyrosine kinase, is frequently detected in thyroid carcinomas, and though controversial (Mitsiades et al 2006), this pathway has been proposed to be important for thyroid carcinoma proliferation and metastasis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of EGF in thyroid associated with thyroid neoplasm, carcinoma and metastasis
13) Confidence 0.25 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.24 Pain Relevance 0.05
In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.
Positive_regulation (induced) of Gene_expression (expression) of epidermal growth factor
14) Confidence 0.22 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19447859 Disease Relevance 0.56 Pain Relevance 0.24
The human EGF receptor-2 oncogene (Her-2) is constitutively overexpressed in approximately 30% of breast cancers and is associated with a poor patient prognosis [71].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGF associated with breast cancer
15) Confidence 0.18 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.56 Pain Relevance 0
In addition, celecoxib affected the proliferation pathway by causing decreased expression of epidermal growth factor (EGF) receptor, FGF receptor 2, transforming growth factor-?
Positive_regulation (causing) of Gene_expression (expression) of epidermal growth factor
16) Confidence 0.16 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.48 Pain Relevance 0.09
In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.
Positive_regulation (induced) of Gene_expression (expression) of epidermal growth factor
17) Confidence 0.16 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19447859 Disease Relevance 0.56 Pain Relevance 0.24
Consistent with this hypothesis, paracrine growth factors that are normally secreted by prostate stroma cells, such as epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) or interleukin 6 (IL6), are found to be overexpression in hormone-refractory cancer in association with a switch to autocrine production by cancer epithelial cells [16].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGF in HGF associated with cancer
18) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.75 Pain Relevance 0
Injured LECs at capsulotomy edges show enhanced expression of EGF receptors, increasing their responsiveness to EGF in the aqueous humor [52].
Positive_regulation (enhanced) of Gene_expression (expression) of EGF in edges
19) Confidence 0.13 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.88 Pain Relevance 0
These data strongly confirm that EGF produced an increase of p-AKT in the less sensitive gefitinib cell lines.
Positive_regulation (increase) of Gene_expression (produced) of EGF
20) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.38 Pain Relevance 0

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