INT80969

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Context Info
Confidence 0.76
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 18.33
Pain Relevance 8.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
monocyte 6
granulocytes 2
respiratory 2
plasma 1
cartilage 1
IL8 (Oryctolagus cuniculus)
Pain Term Frequency Confidence Heat
cytokine 131 100.00 Very High Very High Very High
Inflammation 57 100.00 Very High Very High Very High
Osteoarthritis 35 99.60 Very High Very High Very High
Catecholamine 4 97.66 Very High Very High Very High
Angina 15 97.60 Very High Very High Very High
Nerve growth factor 4 96.48 Very High Very High Very High
fibrosis 3 96.40 Very High Very High Very High
Versed 20 95.28 Very High Very High Very High
Analgesic 15 95.08 Very High Very High Very High
Pain score 1 94.48 High High
Disease Term Frequency Confidence Heat
Necrosis 60 100.00 Very High Very High Very High
INFLAMMATION 95 100.00 Very High Very High Very High
Cancer 15 100.00 Very High Very High Very High
Obesity 9 99.70 Very High Very High Very High
Osteoarthritis 35 99.60 Very High Very High Very High
Gastritis 16 99.52 Very High Very High Very High
Myocardial Reperfusion Injury 5 99.44 Very High Very High Very High
Injury 46 99.06 Very High Very High Very High
Lung Injury 99 98.94 Very High Very High Very High
Cv General 3 Under Development 15 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to determine the role of the CD11b-dependent respiratory burst in neutrophil oxidant generation and activation, interleukin-8 (IL-8) production, and myofiber damage after muscle stretch injury by using the monoclonal antibody M1/70 to block this pathway.
Gene_expression (production) of IL-8 in respiratory associated with injury
1) Confidence 0.76 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12730143 Disease Relevance 0.24 Pain Relevance 0.07
The purpose of this study was to determine the role of the CD11b-dependent respiratory burst in neutrophil oxidant generation and activation, interleukin-8 (IL-8) production, and myofiber damage after muscle stretch injury by using the monoclonal antibody M1/70 to block this pathway.
Gene_expression (production) of interleukin-8 in respiratory associated with injury
2) Confidence 0.76 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12730143 Disease Relevance 0.24 Pain Relevance 0.07
IL-8 was detected only during the acute stage.
Gene_expression (detected) of IL-8
3) Confidence 0.73 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 14720196 Disease Relevance 0.24 Pain Relevance 0
Transforming growth factor-beta induces collagen synthesis without inducing IL-8 production in mesothelial cells.
Gene_expression (production) of IL-8 in mesothelial cells
4) Confidence 0.59 Published 2003 Journal Eur. Respir. J. Section Title Doc Link 12952247 Disease Relevance 0.74 Pain Relevance 0.37
The suppositories contained human recombinant IL-8 (200 ng), IL-1 (200 ng), IL-8 (200 ng) + IL-1 (200 ng) or vehicle Witepsol base, 500 microliters).
Gene_expression (contained) of IL-8
5) Confidence 0.55 Published 1999 Journal Hum. Reprod. Section Abstract Doc Link 10100010 Disease Relevance 0.17 Pain Relevance 0.17
The suppositories contained human recombinant IL-8 (200 ng), IL-1 (200 ng), IL-8 (200 ng) + IL-1 (200 ng) or vehicle Witepsol base, 500 microliters).
Gene_expression (contained) of IL-8
6) Confidence 0.55 Published 1999 Journal Hum. Reprod. Section Abstract Doc Link 10100010 Disease Relevance 0.17 Pain Relevance 0.17
BALF levels of AST, LDH, and IL-8
Gene_expression (levels) of IL-8
7) Confidence 0.32 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779272 Disease Relevance 0 Pain Relevance 0
However, our results showed that there were no significant differences of the levels of BALF AST, LDH, and IL-8 between HPHC and HPNC group.
Gene_expression (levels) of IL-8
8) Confidence 0.32 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779272 Disease Relevance 0.55 Pain Relevance 0.03
The levels of LDH, AST and IL-8 in the BALF, measured at the end of the experimental period, were significantly higher in the HPHC and HPNC groups when compared with the control group (p<0.05) (Fig. 4).
Gene_expression (levels) of IL-8
9) Confidence 0.32 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779272 Disease Relevance 0 Pain Relevance 0
The assay kit cross-reacts with IL-8, and rabbit recombinant IL-8 was used as the standard (22).


Gene_expression (reacts) of IL-8
10) Confidence 0.27 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822264 Disease Relevance 0.09 Pain Relevance 0
The wet weight/dry weight (W/D) ratio of lung and lung injury score of the lung, and number of leukocyte, percent of polymorphonuclear neutrophil (PMN) cells, concentration of albumin, thromboxane B2 (TxB2), and IL-8 in bronchoalveolar lavage fluid (BALF) were measured.


Gene_expression (concentration) of IL-8 in polymorphonuclear neutrophil associated with lung injury
11) Confidence 0.24 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822264 Disease Relevance 0.37 Pain Relevance 0
And it increased W/D ratio of lung, lung injury score and leukocyte count, percentage of PMN cells, concentration of albumin, thromboxane B2 and IL-8 in BALF.
Gene_expression (concentration) of IL-8 in leukocyte associated with lung injury
12) Confidence 0.24 Published 2004 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2822264 Disease Relevance 0.42 Pain Relevance 0
Previously, we have demonstrated that tumor necrosis factor-alpha (TNF-alpha) and gram-negative bacterial lipopolysaccharide stimulate production of IL-6 and IL-8 and activation of the transcription factor NF-kappaB in the well-differentiated pancreatic ductal adenocarcinoma cell lines CAPAN-1 and CAPAN-2.
Gene_expression (production) of IL-8 associated with adenocarcinoma, necrosis and cancer
13) Confidence 0.08 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11768272 Disease Relevance 0.66 Pain Relevance 0.18
In these studies we have examined the effect of chain-breaking and glutathione-enhancing antioxidants on NF-kappaB activation and production of IL-6 and IL-8 in these cell lines.
Gene_expression (production) of IL-8
14) Confidence 0.08 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11768272 Disease Relevance 0.59 Pain Relevance 0.21
It functions by: (1) mediating the most effective destruction of cartilage; (2) regulating bone re-absorption; (3) enhancing the destructive inflammatory process of OA by stimulating the production of IL-8 in synovial tissue macrophages, fibroblasts and chondrocytes; (4) promoting scarring and fibrosis by directly or indirectly stimulating fibroblast proliferation, and (5) prolonging the survival of neutrophils and boosting the inflammatory process.
Gene_expression (production) of IL-8 in cartilage associated with fibrosis, inflammation, keloid scars and osteoarthritis
15) Confidence 0.06 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996802 Disease Relevance 0.87 Pain Relevance 0.39
Inflammatory may be observed in the local ischemic tissues, and thus a lot of chemotatic factors including interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), stromal cell-derived factor (SDF-1) and tumor necrosis factor (TNF) are produced.
Gene_expression (produced) of interleukin-8 in monocyte associated with necrosis, inflammation and cancer
16) Confidence 0.05 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3020395 Disease Relevance 0.82 Pain Relevance 0.08
Inflammatory may be observed in the local ischemic tissues, and thus a lot of chemotatic factors including interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), stromal cell-derived factor (SDF-1) and tumor necrosis factor (TNF) are produced.
Gene_expression (produced) of IL-8 in monocyte associated with necrosis, inflammation and cancer
17) Confidence 0.04 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3020395 Disease Relevance 0.81 Pain Relevance 0.08
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Gene_expression (expression) of IL-8 in granulocytes
18) Confidence 0.04 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.33 Pain Relevance 0.36
NCR suppressed the increase of inflammatory cytokines such as IL-6 and IL-8 levels, and reduced myocardial reperfusion injury.
Gene_expression (levels) of IL-8 associated with myocardial reperfusion injury, inflammation and cytokine
19) Confidence 0.04 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.34 Pain Relevance 0.33
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Gene_expression (production) of IL-8 in granulocytes
20) Confidence 0.03 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.32 Pain Relevance 0.36

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