INT8097

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Context Info
Confidence 0.77
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 122
Total Number 124
Disease Relevance 75.94
Pain Relevance 28.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
pancreas 6
tear 4
Urine 4
platelet 2
fibroblasts 2
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 821 100.00 Very High Very High Very High
cytokine 743 100.00 Very High Very High Very High
Nerve growth factor 62 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
COX-2 inhibitor 50 99.90 Very High Very High Very High
interstitial cystitis 948 99.84 Very High Very High Very High
Inflammation 473 99.52 Very High Very High Very High
Pain 143 99.32 Very High Very High Very High
chemokine 231 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1390 99.98 Very High Very High Very High
Congenital Anomalies 14 99.92 Very High Very High Very High
Interstitial Cystitis 948 99.84 Very High Very High Very High
Pancreatic Cancer 274 99.84 Very High Very High Very High
Schizophrenia 50 99.76 Very High Very High Very High
Apoptosis 372 99.70 Very High Very High Very High
Adenocarcinoma 104 99.64 Very High Very High Very High
Solid Tumor 48 99.64 Very High Very High Very High
Familial Adenomatous Polyposis 17 99.60 Very High Very High Very High
INFLAMMATION 564 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EGF receptor, EGF and TGF-alpha are expressed in the normal human pancreas, and are over-expressed in human pancreatic cancer.
Gene_expression (expressed) of EGF in pancreas associated with pancreatic cancer
1) Confidence 0.77 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.75 Pain Relevance 0.33
The EGF receptor, EGF and TGF-alpha are expressed in the normal human pancreas, and are over-expressed in human pancreatic cancer.
Gene_expression (expressed) of EGF in pancreas associated with pancreatic cancer
2) Confidence 0.77 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.75 Pain Relevance 0.33
Prostate cancer cells generated during intermittent androgen ablation acquire a growth advantage and exhibit changes in epidermal growth factor receptor expression.
Gene_expression (expression) of epidermal growth factor associated with reprotox - general 1
3) Confidence 0.77 Published 2004 Journal Prostate Section Title Doc Link 15065088 Disease Relevance 0.19 Pain Relevance 0.14
The expression of EGF receptor protein decreased following each cycle of androgen ablation and increased subsequently after androgen supplementation.
Gene_expression (expression) of EGF
4) Confidence 0.77 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0.06 Pain Relevance 0
There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor.
Gene_expression (overexpression) of EGF
5) Confidence 0.75 Published 1992 Journal J. Pathol. Section Abstract Doc Link 1361525 Disease Relevance 0.49 Pain Relevance 0.07
In this study, we examined in human colon cancer cells the effect of indomethacin and NS-398 (a pre-clinical selective COX-2 inhibitor) on expression of 96 genes of the EGF/PDGF signaling pathways essential for cell proliferation, migration, and survival.
Gene_expression (expression) of EGF in colon associated with colon cancer and cox-2 inhibitor
6) Confidence 0.75 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.42 Pain Relevance 0.35
In contrast, EGF immunoreactivity was not found in normal pancreas, but was expressed in 12 per cent of pancreatic carcinomas.
Gene_expression (expressed) of EGF in pancreas associated with pancreatic cancer
7) Confidence 0.74 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.71 Pain Relevance 0.19
Overexpression of the epidermal growth factor receptor (EGFR) has been reported as an important molecular abnormality in human pancreatic cancer.
Gene_expression (Overexpression) of epidermal growth factor associated with pancreatic cancer
8) Confidence 0.74 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.36 Pain Relevance 0.12
Upregulation of EGF/EGFR expression has been reported in metastatic PCa [30].
Gene_expression (expression) of EGF associated with reprotox - general 1
9) Confidence 0.73 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.59 Pain Relevance 0.12
Cells exposed to EGF +/- the inactive phospholipase C inhibitor U73343 demonstrated a significant increase in nucleic acid and protein.
Gene_expression (exposed) of EGF
10) Confidence 0.67 Published 2000 Journal J. Gastrointest. Surg. Section Abstract Doc Link 10675238 Disease Relevance 0.20 Pain Relevance 0.30
The EGF receptor, EGF and TGF-alpha are expressed in the normal human pancreas, and are over-expressed in human pancreatic cancer.
Gene_expression (expressed) of EGF in pancreas associated with pancreatic cancer
11) Confidence 0.67 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.75 Pain Relevance 0.33
The EGF receptor, EGF and TGF-alpha are expressed in the normal human pancreas, and are over-expressed in human pancreatic cancer.
Gene_expression (over-expressed) of EGF in pancreas associated with pancreatic cancer
12) Confidence 0.67 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.78 Pain Relevance 0.35
CONCLUSIONS: Changes in the expression of the EGF receptor occur during intermittent androgen ablation but they cannot be solely responsible for increased basal proliferation.
Gene_expression (expression) of EGF
13) Confidence 0.67 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0 Pain Relevance 0
Alternatively, other ligands and receptors of the EGF system may become overexpressed during prolonged withdrawal and supplementation of androgenic hormones in prostate cancer therapy.


Gene_expression (overexpressed) of EGF
14) Confidence 0.67 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0 Pain Relevance 0
Biotinylated HBGF2 and EGF (B-GF) were exposed to complexes of biotinylated collagen (B-COL)-avidin (A) and detected with peroxidase-labeled avidin (AP) followed by chromagen formation on nitrocellulose paper.
Gene_expression (detected) of EGF
15) Confidence 0.65 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0
We analysed by immunocytochemical staining a retrospective series of human pancreatic cancers, chronic pancreatitis, and normal fetal and adult pancreatic tissues for the presence of TGF-alpha and epidermal growth factor (EGF).
Gene_expression (presence) of epidermal growth factor associated with pancreatic cancer and chronic pancreatitis
16) Confidence 0.64 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.69 Pain Relevance 0.19
We analysed by immunocytochemical staining a retrospective series of human pancreatic cancers, chronic pancreatitis, and normal fetal and adult pancreatic tissues for the presence of TGF-alpha and epidermal growth factor (EGF).
Gene_expression (presence) of EGF associated with pancreatic cancer and chronic pancreatitis
17) Confidence 0.64 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.69 Pain Relevance 0.19
APF can inhibit HB-EGF production by bladder epithelial cells [8], indicating a possible mechanism for APF's antiproliferative activity.
Gene_expression (production) of EGF in bladder
18) Confidence 0.64 Published 2005 Journal BMC Urol Section Body Doc Link PMC1131910 Disease Relevance 0.60 Pain Relevance 0.60
AG1478 also suppressed the effect of exogenous EGF in upregulating total VGSC protein expression; there was no difference in the levels of VGSC protein expression for EGF+AG1478 and AG1478 (p > 0.05; n = 6; Fig. 3B &3C).
Gene_expression (expression) of EGF associated with sodium channel
19) Confidence 0.63 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.78
Additional PCRs confirmed expression of EGF receptors in PC-3M cells (not shown) [23].


Gene_expression (expression) of EGF
20) Confidence 0.63 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0 Pain Relevance 0.12

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