INT80972

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 104
Total Number 109
Disease Relevance 102.74
Pain Relevance 16.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
leukocytes 9
apoptotic cells 6
joints 3
RG2 3
synovium 3
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 2183 100.00 Very High Very High Very High
rheumatoid arthritis 592 99.84 Very High Very High Very High
Inflammation 527 99.60 Very High Very High Very High
ischemia 88 98.92 Very High Very High Very High
Spinal cord 41 98.00 Very High Very High Very High
cINOD 46 97.56 Very High Very High Very High
aspirin 2 96.40 Very High Very High Very High
Chronic pancreatitis 41 95.96 Very High Very High Very High
Crohn's disease 38 94.88 High High
fibrosis 79 94.52 High High
Disease Link Frequency Relevance Heat
Apoptosis 3208 100.00 Very High Very High Very High
Cancer 2226 100.00 Very High Very High Very High
Experimental Arthritis 1443 100.00 Very High Very High Very High
Infection 148 100.00 Very High Very High Very High
Necrosis 106 100.00 Very High Very High Very High
Disease 751 99.88 Very High Very High Very High
Colon Cancer 149 99.88 Very High Very High Very High
Rheumatoid Arthritis 593 99.84 Very High Very High Very High
Complex Regional Pain Syndromes 196 99.68 Very High Very High Very High
INFLAMMATION 599 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is already some overexpression of p53 in the preclinical phase

and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Gene_expression (overexpression) of p53 associated with arthritis
1) Confidence 0.78 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.30 Pain Relevance 0.39
Taken together, significant apoptosis only occurs late in AA and it

follows marked p53 overexpression, making it is useful model for testing proapoptotic therapies.

Gene_expression (overexpression) of p53 associated with apoptosis and arthritis
2) Confidence 0.78 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.43 Pain Relevance 0.26
The

increased expression of p53 in the joints of rats with chronic AA was even greater than that observed in synovial tissue of RA patients with long-standing disease.

Gene_expression (expression) of p53 in joints associated with rheumatoid arthritis, disease and arthritis
3) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.38 Pain Relevance 0.35
AA is not the best model for p53 gene therapy,

however, because dramatic p53 overexpression occurs in the latter stages of the disease.



Gene_expression (overexpression) of p53 associated with disease and arthritis
4) Confidence 0.78 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.15 Pain Relevance 0.19
The results indicate that,

although there was sufficient DNA damage to cause an increment in p53 expression in the early phase, DNA strand breaks that can be detected by TUNEL assays only occurred in chronic AA.

Gene_expression (expression) of p53 associated with arthritis
5) Confidence 0.78 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.34 Pain Relevance 0.32
There is already some overexpression of p53 in the preclinical

phase and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Gene_expression (expression) of p53 associated with arthritis
6) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.17 Pain Relevance 0.35
There is already some overexpression of p53 in the preclinical

phase and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Gene_expression (overexpression) of p53 associated with arthritis
7) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.15 Pain Relevance 0.38
There is already some overexpression of p53 in the preclinical phase

and during the onset of the arthritis, with an additional increment in p53 expression during accelerating and chronic arthritis.

Gene_expression (expression) of p53 associated with arthritis
8) Confidence 0.78 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.11 Pain Relevance 0.36
Expression of p53 in different phases of adjuvant arthritis
Gene_expression (Expression) of p53 associated with experimental arthritis and arthritis
9) Confidence 0.78 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 0.92 Pain Relevance 0.23
Overexpression of p53 protein on day 23 was confirmed by immunohistochemistry

in a separate experiment in six rats with AA.

Gene_expression (Overexpression) of p53 associated with arthritis
10) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.73 Pain Relevance 0.21
Subsequently, we examined expression of the tumor suppressor gene

p53, because this is a key regulator of apoptosis.

Spec (examined) Gene_expression (expression) of p53 associated with cancer and apoptosis
11) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.73 Pain Relevance 0.16
Overexpression of p53 was

observed in the intimal lining layer and synovial sublining in all rats on day 23.

Gene_expression (Overexpression) of p53
12) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.76 Pain Relevance 0.23
This

indicates that, although there was sufficient DNA damage to cause an increment in p53 expression in the early phases, DNA strand breaks that can be detected by TUNEL assays only occurred in chronic AA.

Gene_expression (expression) of p53 associated with arthritis
13) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.96 Pain Relevance 0.31
Expression of p53

in pooled rat AA joint extracts gradually increased from day 0 (6 arbitrary units) to day 23 (173 arbitrary units), which was markedly higher than p53 levels in RA synovium (32 arbitrary units; Table 1).

Gene_expression (Expression) of p53 in synovium associated with rheumatoid arthritis and arthritis
14) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 0.74 Pain Relevance 0.17
Therefore,

we evaluated the number of apoptotic cells and the expression of p53 in various phases of AA.


Gene_expression (expression) of p53 in apoptotic cells associated with apoptosis and arthritis
15) Confidence 0.78 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.97 Pain Relevance 0.50
The important role of adenovirus-mediated wild type p53 gene transfer has been shown in several realms of tumor biology.
Gene_expression (transfer) of p53 associated with cancer
16) Confidence 0.75 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.31 Pain Relevance 0
They emphasized the safety of adenovirus-mediated tumor-suppressor transduction into hepatocytes and over-expression of wildtype p53 transfected into quiescent and regenerating hepatocytes.
Gene_expression (over) of p53 in hepatocytes associated with cancer
17) Confidence 0.75 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.46 Pain Relevance 0
In vitro cell proliferation analyses was done to evaluate the effect of adenovirus-mediated wild-type p53 expression.
Gene_expression (expression) of p53
18) Confidence 0.75 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.66 Pain Relevance 0
Theoretically, this analysis allows determination of whether the transfection of wild-type p53 suppresses tumor cells before performing the in vivo experiment.
Spec (whether) Gene_expression (transfection) of p53 associated with cancer
19) Confidence 0.75 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.79 Pain Relevance 0
Theoretically, this analysis allows determination of whether the transfection of wild-type p53 suppresses tumor cells before performing an in vivo experiment.
Spec (whether) Gene_expression (transfection) of p53 associated with cancer
20) Confidence 0.75 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.17 Pain Relevance 0

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