INT80978

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.68
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DES) cytoskeleton (DES) intracellular (DES)
cytoskeleton organization (DES) cytoplasm (DES)
Anatomy Link Frequency
smooth muscle 2
globules 2
DES (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 91.12 High High
abdominal pain 1 80.84 Quite High
Angina 4 73.36 Quite High
Percutaneous transluminal coronary angioplasty 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 99.76 Very High Very High Very High
Malignant Neoplastic Disease 6 99.40 Very High Very High Very High
Rhinitis 1 98.08 Very High Very High Very High
Cardiovascular Disease 46 97.36 Very High Very High Very High
Recurrence 2 97.24 Very High Very High Very High
Necrosis 3 91.64 High High
Hemorrhage 2 91.12 High High
Retinoblastoma 2 85.76 High High
Benign Tumor 1 83.52 Quite High
Hypoglycemia 1 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tumor cells were all immunoreactive for vimentin, CD 34, and focally actin-positive in one case, but not for keratin, desmin, S-100 protein, carcinoembryonic antigen, alpha 1-ACT and F VIII-related antigen, supported a primitive mesenchymal origin. p53 protein was expressed in two of the malignant cases.
Positive_regulation (immunoreactive) of Gene_expression (expressed) of desmin associated with malignant neoplastic disease and cancer
1) Confidence 0.49 Published 1999 Journal Lung Cancer Section Abstract Doc Link 10100146 Disease Relevance 2.44 Pain Relevance 0.12
The morules showed positive thyroid transcription factor-1 staining, weak keratin staining, and negative staining for smooth muscle actin, desmin, and HMB-45.
Positive_regulation (positive) of Gene_expression (staining) of desmin in smooth muscle
2) Confidence 0.49 Published 2004 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15272538 Disease Relevance 0.89 Pain Relevance 0.10
Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.
Positive_regulation (positive) of Gene_expression (staining) of desmin in globules associated with rhinitis and cancer
3) Confidence 0.49 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.87 Pain Relevance 0.08
The safety concerns have been mainly directed at the first generation of DES.
Positive_regulation (generation) of Gene_expression (generation) of DES
4) Confidence 0.28 Published 2007 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2323487 Disease Relevance 0.48 Pain Relevance 0

General Comments

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