INT80981

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 19
Total Number 22
Disease Relevance 1.86
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
brain 6
Caco-2 4
plasma 1
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 47 100.00 Very High Very High Very High
Cannabinoid 8 100.00 Very High Very High Very High
addiction 2 99.92 Very High Very High Very High
Bioavailability 10 99.82 Very High Very High Very High
Morphine 33 99.32 Very High Very High Very High
Opioid 4 98.84 Very High Very High Very High
opiate 2 98.40 Very High Very High Very High
Antinociceptive 2 98.16 Very High Very High Very High
Analgesic 5 96.88 Very High Very High Very High
tail-flick 4 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.86 Very High Very High Very High
Myeloid Leukemia 101 99.14 Very High Very High Very High
Cancer 7 98.00 Very High Very High Very High
Primary Sclerosing Cholangitis 1 91.36 High High
Epilepsy 4 86.80 High High
Appetite Loss 1 84.92 Quite High
Vomiting 1 84.00 Quite High
Leukemia 9 71.12 Quite High
Toxicity 6 70.12 Quite High
Repression 1 65.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PURPOSE: This study was conducted to examine the influence of P-glycoprotein (P-gp) modulation on the pharmacodynamics of the model opioid peptide DPDPE.
Spec (examine) Regulation (modulation) of P-gp associated with opioid
1) Confidence 0.62 Published 1999 Journal Pharm. Res. Section Abstract Doc Link 10100317 Disease Relevance 0 Pain Relevance 0.32
The objective of the present study was to examine the time course and concentration dependence of modulation of P-glycoprotein (P-gp) activity in the blood-brain barrier (BBB) with consequent influence on substrate uptake into brain tissue.
Regulation (modulation) of P-gp in brain associated with addiction
2) Confidence 0.60 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721332 Disease Relevance 0 Pain Relevance 0.19
The present studies demonstrate that P-gp function at the BBB can be modulated by rifampin in a dose- and concentration-dependent manner.
Regulation (modulated) of P-gp
3) Confidence 0.60 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721332 Disease Relevance 0 Pain Relevance 0.07
The aim of this paper is to review the regulation of P-glycoprotein (P-gp) by dietary components and to correlate the changes in cellular P-gp function and expression with drug bioavailability.
Regulation (regulation) of P-gp associated with bioavailability
4) Confidence 0.58 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Abstract Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.14
Dietary regulation of P-gp function and expression.
Regulation (regulation) of P-gp
5) Confidence 0.58 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Title Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.15
PURPOSE: This study assessed the influence of mdr1a P-glycoprotein (P-gp) gene disruption, gender and concentration on initial brain uptake clearance (Clup) of morphine, quinidine and verapamil.
Regulation (influence) of P-gp in brain associated with morphine
6) Confidence 0.45 Published 2001 Journal Pharm. Res. Section Abstract Doc Link 11496955 Disease Relevance 0 Pain Relevance 0.10
PURPOSE: This study assessed the influence of mdr1a P-glycoprotein (P-gp) gene disruption, gender and concentration on initial brain uptake clearance (Clup) of morphine, quinidine and verapamil.
Regulation (influence) of mdr1a in brain associated with morphine
7) Confidence 0.45 Published 2001 Journal Pharm. Res. Section Abstract Doc Link 11496955 Disease Relevance 0 Pain Relevance 0.10
Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.
Regulation (Effect) of mdr1a in brain
8) Confidence 0.45 Published 2001 Journal Pharm. Res. Section Title Doc Link 11496955 Disease Relevance 0 Pain Relevance 0.09
We used P-gp knockout mice (Mdr1a) and their controls to determine where P-gp is involved in the saturable efflux systems of four other endogenous opiate-modulating peptides across the blood-brain barrier (BBB).
Regulation (controls) of Mdr1a in brain associated with targeted disruption and opiate
9) Confidence 0.37 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11854138 Disease Relevance 0.16 Pain Relevance 0.35
Effects of capsaicin on P-gp function and expression in Caco-2 cells.
Regulation (Effects) of P-gp in Caco-2 associated with qutenza
10) Confidence 0.36 Published 2006 Journal Biochem. Pharmacol. Section Title Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.84
In summary, the published literature has provided extensive data supporting the modulation of drug bioavailability through P-gp regulation by components in food groups such as fruit juices, spices, herbs, cruciferous vegetables and green tea.
Regulation (regulation) of P-gp associated with bioavailability
11) Confidence 0.26 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Abstract Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.17
In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.
Regulation (regulation) of P-gp protein in Caco-2 associated with qutenza
12) Confidence 0.21 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.71
The aim of the present study was to evaluate the chronicity and reversibility of the modulating effect of capsaicin on both the P-gp expression and activity in the Caco-2 cell monolayers.
Regulation (effect) of P-gp in Caco-2 associated with qutenza
13) Confidence 0.21 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.56
In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.
Regulation (regulation) of P-gp in Caco-2 associated with qutenza
14) Confidence 0.21 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.71
The effects of the P-gp inhibitor GF120918 on brain distribution and antinociceptive effects of morphine were examined in a rat cerebral microdialysis model.
Spec (examined) Regulation (effects) of P-gp in brain associated with antinociceptive and morphine
15) Confidence 0.14 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 10383928 Disease Relevance 0 Pain Relevance 0.88
This showed that P-gp was not affected by pH conditions.
Neg (not) Regulation (affected) of P-gp
16) Confidence 0.08 Published 2004 Journal Drug Dev Ind Pharm Section Body Doc Link 15244080 Disease Relevance 0 Pain Relevance 0
Two studies evaluating induction chemotherapy with or without cyclosporine in poor risk AML patients suggested a potential benefit of P-gP modulation in these patients [45, 46].
Regulation (modulation) of P-gP associated with myeloid leukemia
17) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902223 Disease Relevance 0.87 Pain Relevance 0
This study was undertaken to examine the effect of cannabinoids on P-gp.
Spec (examine) Regulation (effect) of P-gp associated with cannabinoid
18) Confidence 0.06 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.43 Pain Relevance 0.41
None of the transport rates for these drugs were affected by P-gp inhibitors.
Regulation (affected) of P-gp
19) Confidence 0.05 Published 2006 Journal J Drug Target Section Abstract Doc Link 16882549 Disease Relevance 0.24 Pain Relevance 0.17
Our own preliminary results did not confirm a regulation of p-glycoprotein and MDR-1 but indicate that Abcg2 and the glucose transporter Slc2a1 were notably up-regulated in MBEs by Wnt3aCM (unpublished data).
Regulation (regulation) of MDR-1
20) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0.17 Pain Relevance 0

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