INT81002

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1999
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
synapse 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sumatriptan 11 100.00 Very High Very High Very High
fluoxetine 8 95.96 Very High Very High Very High
agonist 6 94.88 High High
Serotonin 1 91.84 High High
Hippocampus 1 78.48 Quite High
Substantia nigra 6 77.20 Quite High
antagonist 2 67.76 Quite High
Disease Link Frequency Relevance Heat
Body Weight 3 98.92 Very High Very High Very High
Affective Disorder 1 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dimerization of sumatriptan increased the binding affinity for h 5-HT1B (pKi: 9.22 vs. 7.79 for sumatriptan), h 5-HT1D (9.07 vs. 8.08) and also h 5-HT1A receptors (7.80 vs. 6.40), while the binding affinity for h 5-ht1E (6.67 vs. 6.19) and h 5-ht1F (7.37 vs. 7.78) receptors was not affected.
Positive_regulation (increased) of Regulation (affinity) of 5-HT1A associated with sumatriptan
1) Confidence 0.49 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10101238 Disease Relevance 0 Pain Relevance 0.68
We hypothesized that the regulation of postsynaptic 5-HT1A receptors is dependent on the levels of 5-HT in the synapse.
Positive_regulation (dependent) of Regulation (regulation) of 5-HT1A in synapse
2) Confidence 0.45 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14604841 Disease Relevance 0.33 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox