INT8101

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Context Info
Confidence 0.31
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 16.20
Pain Relevance 6.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
macrophages 2
sperm 2
chondrocytes 1
HSC 1
brain 1
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 513 100.00 Very High Very High Very High
imagery 66 100.00 Very High Very High Very High
chemokine 51 99.84 Very High Very High Very High
antiepileptic Drug 27 98.76 Very High Very High Very High
Bioavailability 25 97.08 Very High Very High Very High
withdrawal 33 96.16 Very High Very High Very High
Analgesic 44 95.76 Very High Very High Very High
Opioid 201 95.36 Very High Very High Very High
Pain 146 95.04 Very High Very High Very High
Morphine 107 93.52 High High
Disease Link Frequency Relevance Heat
Cirrhosis 445 100.00 Very High Very High Very High
Recurrence 6 99.72 Very High Very High Very High
Epilepsy 35 99.62 Very High Very High Very High
Cancer 401 99.52 Very High Very High Very High
Reprotox - General 1 111 99.10 Very High Very High Very High
Metastasis 135 99.04 Very High Very High Very High
Chromosome Aberrations 4 98.68 Very High Very High Very High
Adhesions 67 98.24 Very High Very High Very High
Infection 90 98.12 Very High Very High Very High
Breast Cancer 86 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In-vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs.
In-vitro protein Binding (interaction) of
1) Confidence 0.31 Published 1992 Journal J. Pharm. Pharmacol. Section Title Doc Link 1361542 Disease Relevance 0.08 Pain Relevance 0.19
In vitro studies have demonstrated that gemfibrozil interacts with the same family of glucuronidation enzymes involved in statin metabolism.35 As a result of inhibiting statin glucuronidation, gemfibrozil coadministration with statins generally produces increases in the statin AUC.
In vitro Binding (interacts) of
2) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.20 Pain Relevance 0.12
This binding determines the physiological tonicity (that is, osmotic pressure) of the extracellular fluid around chondrocytes in vivo, but the tonicity indirectly also largely depends on the quality of the collagen network.
in vivo Binding (binding) of in chondrocytes
3) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.22 Pain Relevance 0.07
In vivo experimental data to verify the prediction by the numerical simulations that scaffold porosity is a key parameter in the design of meniscus biomaterial implants is currently lacking and needs to be the focus of future studies.
In vivo Binding (lacking) of
4) Confidence 0.04 Published 2007 Journal The Open Biomedical Engineering Journal Section Body Doc Link PMC2701084 Disease Relevance 0.13 Pain Relevance 0
In vitro systems designed to evaluate permeability, interaction with membrane transporter systems, and metabolic stability in cell models with human relevance reduced this failure rate to less than 10% by 2000 (Fig. 2) [2].
In vitro Binding (interaction) of
5) Confidence 0.04 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.37 Pain Relevance 0.05
This allows evaluation of cell-to-cell interactions in vitro.
in vitro Binding (interactions) of
6) Confidence 0.04 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.35 Pain Relevance 0.07
The authors conducted Medline and PubMed search from 1968 to February 2010 for English- language articles describing the interaction between PN and antiepileptic drugs; the search terms used were anti-epileptic drugs, PN, and/or interaction, and/or in vitro.
in vitro Binding (interaction) of associated with epilepsy and antiepileptic drug
7) Confidence 0.03 Published 2010 Journal Nutr J Section Body Doc Link PMC3022641 Disease Relevance 0.16 Pain Relevance 0.09
A Novel In Vitro Method for the Detection and Characterization of Photosensitizers

Photoactivation and binding of photoactive chemicals to proteins is a known prerequisite for the formation of immunogenic photoantigens and the induction of photoallergy.

In Vitro Binding (binding) of associated with photoallergic dermatitis
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Title Doc Link PMC3009729 Disease Relevance 0.40 Pain Relevance 0
Celecoxib inhibits vascular channel formation in vitro
in vitro Binding (formation) of
9) Confidence 0.02 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.06 Pain Relevance 0
In vitro, the variant protein has been demonstrated to exhibit three times greater binding affinity for the endopeptide ?
In vitro Binding (binding) of
10) Confidence 0.02 Published 2007 Journal Crit Care Section Body Doc Link PMC2151888 Disease Relevance 0.22 Pain Relevance 1.06
It is important to note that the UCUAN sequence significantly reduces interaction with CFIm in vitro (Venkataraman et al, 2005).
in vitro Binding (interaction) of
11) Confidence 0.02 Published 2010 Journal EMBO J Section Body Doc Link PMC2876958 Disease Relevance 0 Pain Relevance 0
In vivo brain imaging with ?
In vivo Binding (imaging) of in brain associated with imagery
12) Confidence 0.02 Published 2008 Journal Brain Section Body Doc Link PMC2367693 Disease Relevance 0.37 Pain Relevance 1.09
The phenolic compound, hydroxytyrosol has been noted to completely inhibit platelet aggregation in human blood (in vitro) in the range of 100–400 ?
in vitro Binding (aggregation) of in blood
13) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.53 Pain Relevance 0.08
Bone toxicity is not widely recognised in the safety evaluation of silver and silver-containing products, but there are strong indications from in vitro models that Ag+ interacts with and binds to the hydroxyapatite complex and can displace calcium and magnesium ions [128, 129].
in vitro Binding (binds) of associated with toxicity
14) Confidence 0.02 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3003978 Disease Relevance 0.52 Pain Relevance 0
Jones et al. (1991) described the in vivo distribution of [11C]DPN binding in man in relation to the medial (functional subdivision of brain areas mediating the affective-motivational components in pain perception) and lateral pain systems (brain areas mediating sensory-discriminative components in pain perception).
in vivo Binding (binding) of in lateral associated with pain
15) Confidence 0.02 Published 2008 Journal Brain Section Body Doc Link PMC2367693 Disease Relevance 0.48 Pain Relevance 0.89
In our studies, we showed that both conjugates were able to effectively reduce the viability of HSC in vitro.
in vitro Binding (viability) of associated with cirrhosis
16) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.65 Pain Relevance 0
After chemical conjugation of 15dPGJ2 to the carriers, the constructs displayed pharmacological activity and specific receptor-mediated binding to HSC in vitro.
in vitro Binding (binding) of in HSC associated with cirrhosis
17) Confidence 0.02 Published 2007 Journal Pharm Res Section Abstract Doc Link PMC1915609 Disease Relevance 1.03 Pain Relevance 0.09
In vitro receptor interactions differed between both targeted constructs, which led to differences in the hepatocellular distribution in vivo.
In vitro Binding (interactions) of
18) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.63 Pain Relevance 0
Radioactive studies showed significant binding of both constructs to HSC in vitro (Fig. 1).
in vitro Binding (binding) of associated with cirrhosis
19) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.20 Pain Relevance 0.03
In vivo, bisphosphonates bind strongly to hydroxyapatite on the bone surface and are preferentially delivered to sites of increased bone formation or resorption.
In vivo Binding (bind) of
20) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138711 Disease Relevance 1.58 Pain Relevance 0.10

General Comments

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