INT8103

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 40.20
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
germline 2
lung 2
neck 1
proximal regions 1
colon 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 18 99.04 Very High Very High Very High
cINOD 48 98.80 Very High Very High Very High
Enkephalin 1 98.74 Very High Very High Very High
Inflammation 212 98.00 Very High Very High Very High
Pain 24 89.12 High High
Arthritis 319 89.04 High High
Analgesic 18 86.16 High High
aspirin 32 82.80 Quite High
positron emission tomography 39 82.64 Quite High
Chronic pancreatitis 8 81.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 1428 100.00 Very High Very High Very High
Inflammatory Breast Neoplasms 408 99.84 Very High Very High Very High
Aneuploidy 6 99.74 Very High Very High Very High
Mesothelioma 103 99.64 Very High Very High Very High
Toxicity 24 99.64 Very High Very High Very High
Malignant Neoplastic Disease 121 99.60 Very High Very High Very High
Breast Cancer 488 99.56 Very High Very High Very High
Chondrosarcoma 37 99.52 Very High Very High Very High
Syndrome 18 99.30 Very High Very High Very High
Leukemia 26 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These components interact with other cell cycle related genes such as p53.
p53 Binding (interact) of
1) Confidence 0.44 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 1.10 Pain Relevance 0
The p53 tumour suppressor gene and its protein products after point mutations are currently attracting wide attention in the investigation of human tumours.
p53 Binding (attracting) of associated with cancer
2) Confidence 0.37 Published 1993 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8218996 Disease Relevance 0.70 Pain Relevance 0.15
These findings are consistent with the stronger association we observed with NSAID use among those with more aggressive tumors and those with TP53 alteration, suggesting that COX inhibition could be especially relevant for these poorer prognosis tumors.
TP53 Binding (alteration) of associated with cancer and cinod
3) Confidence 0.37 Published 2007 Journal BMC Urol Section Body Doc Link PMC2018698 Disease Relevance 0.93 Pain Relevance 0.73
HCT116 (TP53(+/+)), HCT15 (TP53 mutant) and TP53 null HCT116 (TP53(-/-)) cells were irradiated with gamma rays, and apoptosis was measured at various times after irradiation.
TP53 Binding (irradiated) of associated with apoptosis
4) Confidence 0.36 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.69 Pain Relevance 0.17
HCT116 (TP53(+/+)), HCT15 (TP53 mutant) and TP53 null HCT116 (TP53(-/-)) cells were irradiated with gamma rays, and apoptosis was measured at various times after irradiation.
TP53 Binding (irradiated) of associated with apoptosis
5) Confidence 0.36 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.69 Pain Relevance 0.17
HCT116 (TP53(+/+)), HCT15 (TP53 mutant) and TP53 null HCT116 (TP53(-/-)) cells were irradiated with gamma rays, and apoptosis was measured at various times after irradiation.
TP53 Binding (irradiated) of associated with apoptosis
6) Confidence 0.36 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.69 Pain Relevance 0.17
Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma.
p53 Binding (compared) of associated with pancreatic cancer and enkephalin
7) Confidence 0.36 Published 2006 Journal J. Gastroenterol. Section Title Doc Link 16988769 Disease Relevance 0.54 Pain Relevance 0.18
TP53 is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor.
TP53 Binding (bind) of associated with cancer
8) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.80 Pain Relevance 0.21
Understanding of the molecular and biochemical mechanisms responsible for mutation of p53 is necessary before change of this molecule can be applied in clinical practice as a prognostic factor.
p53 Binding (mutation) of
9) Confidence 0.34 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.65 Pain Relevance 0
Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.
p53 Binding (accompanied) of in colon associated with colon cancer
10) Confidence 0.34 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.67 Pain Relevance 0.12
[Mutations of ras and p53 genes in human non-small cell lung cancer cell lines and their clinical significance].
p53 Binding ([Mutations) of in lung associated with lung cancer
11) Confidence 0.34 Published 1992 Journal Nippon Geka Gakkai Zasshi Section Title Doc Link 1361656 Disease Relevance 0.36 Pain Relevance 0.06
Using a p53 index of ?
p53 Binding (index) of
12) Confidence 0.33 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.09 Pain Relevance 0
Our previous studies showed that over 46% of the putative promoter sites of 324 miRNAs contain p53 binding site(s).
p53 Binding (binding) of
13) Confidence 0.31 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.56 Pain Relevance 0
The expression of hsa-miR-181b was 3.4-fold higher in 11 tumors with p53 mutations/deletions than the corresponding normal samples with wild type p53 and was strongly associated with p53 mutation status (median: 1.72 vs. 0.50, p = 0.0098) (Figure 4A).
p53 Binding (associated) of associated with cancer
14) Confidence 0.31 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.47 Pain Relevance 0
Like most human IBC samples, MARY-X is ER-negative, progesterone receptor-negative, p53-positive, and epidermal growth factor receptor-positive, but is Her-2/neu-negative.
p53 Binding (negative) of associated with inflammatory breast neoplasms
15) Confidence 0.30 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.36 Pain Relevance 0.11
As alterations to ERBB2, EGFR and TP53 can be associated with greater breast tumor aggressiveness, their roles in IBC have also been investigated.
TP53 Binding (alterations) of associated with inflammatory breast neoplasms, aggression and breast cancer
16) Confidence 0.30 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 2.20 Pain Relevance 0.04
Like most human IBC samples, MARY-X is ER-negative, progesterone receptor-negative, p53-positive, and epidermal growth factor receptor-positive, but is Her-2/neu-negative.
p53 Binding (negative) of associated with inflammatory breast neoplasms
17) Confidence 0.30 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.43 Pain Relevance 0.11
It is connected to three genes: TP53 in its active state in the nucleus (through state_transition), TPPP (TPPP can phosphorylate TP53) and MDM2 (MDM2 can inhibit the activation of TP53).
TP53 Binding (state) of in nucleus
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.51 Pain Relevance 0.03
Similarly in patients with squamous cell carcinoma Seitz et al., identified immunohistochemically a significant association between p53 overexpression and a lower complete response [15].
p53 Binding (association) of associated with skin cancer
19) Confidence 0.27 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.78 Pain Relevance 0
Survivin expression was not associated with p53 or Bax expression (p = 0.9969 and 0.0931, respectively, Table 4)

Survivin, p53, and bax expression and clinico-pathologic characteristics

p53 Binding (associated) of
20) Confidence 0.26 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.32 Pain Relevance 0

General Comments

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