INT81037

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 70
Total Number 74
Disease Relevance 15.31
Pain Relevance 37.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 3
NAc 3
substantia nigra 2
basal ganglia 2
soma 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 3466 100.00 Very High Very High Very High
Dopamine 3362 100.00 Very High Very High Very High
Serotonin 171 100.00 Very High Very High Very High
fluoxetine 101 100.00 Very High Very High Very High
Eae 679 99.92 Very High Very High Very High
imagery 23 99.92 Very High Very High Very High
Nucleus accumbens 176 99.90 Very High Very High Very High
Enkephalin 21 99.76 Very High Very High Very High
Substantia nigra 35 99.50 Very High Very High Very High
Ventral tegmentum 125 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 326 100.00 Very High Very High Very High
Sprains And Strains 163 99.84 Very High Very High Very High
Parkinson's Disease 701 99.82 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 374 99.44 Very High Very High Very High
Disease 357 98.96 Very High Very High Very High
Apoptosis 22 96.52 Very High Very High Very High
Neurodegenerative Disease 19 95.44 Very High Very High Very High
Aging 93 94.64 High High
Drug Induced Neurotoxicity 60 94.44 High High
Urological Neuroanatomy 38 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In heterozygous DAT-KO mice, DAT activity is reduced by 50% and cocaine stimulates locomotion as well as in WT mice; while in homozygous DAT-KO mice, DAT is absent and cocaine has no effect on locomotion [24].
Negative_regulation (reduced) of DAT associated with cocaine
1) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.54
Heterozygous DAT-KO mice [24]and DAT-KD mice have significantly elevated DA tone but in these mice DAT is blocked by cocaine and the mice respond to cocaine similarly to wild type mice.
Negative_regulation (blocked) of DAT associated with dopamine and cocaine
2) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.65
In DAT-KD mice, DAT activity is reduced to 10% of the wild type level, resulting in a hyperdopaminergic tone and increased locomotor activity [18].
Negative_regulation (reduced) of DAT associated with eae
3) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.27 Pain Relevance 0.47
Our results demonstrate that a dramatically reduced DAT activity does not lead to a loss or a reduction of the stimulating effect of cocaine.
Negative_regulation (reduced) of DAT associated with cocaine
4) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.54
In these DAT-CI mice, cocaine suppresses locomotion and does not produce reward, supporting the hypothesis that cocaine blockade of DAT is required for cocaine reward in normal mice [17].
Negative_regulation (blockade) of DAT associated with cocaine
5) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.09 Pain Relevance 0.68
Therefore, the locomotor suppression observed in DAT-CI mice is not due to reduced DA clearance or changes in DA homeostasis but is due to the lack of cocaine inhibition of DAT and to cocaine effects on other cocaine targets.
Negative_regulation (inhibition) of DAT associated with dopamine and cocaine
6) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.76
Cocaine inhibition of SERT and/or NET in the absence of DAT inhibition in DAT-CI mice leads to locomotor suppression.
Negative_regulation (inhibition) of DAT associated with cocaine
7) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.66
Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter (DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine (DA).
Negative_regulation (inhibiting) of dopamine transporter associated with dopamine and cocaine
8) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12006604 Disease Relevance 0.15 Pain Relevance 0.70
Here, we show that DADLE was able to block the protein as well as the functional loss of dopamine transporter (DAT) and tyrosine hydroxylase (TH) induced by methamphetamine.
Negative_regulation (loss) of DAT associated with dopamine
9) Confidence 0.56 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.30
Here, we show that DADLE was able to block the protein as well as the functional loss of dopamine transporter (DAT) and tyrosine hydroxylase (TH) induced by methamphetamine.
Negative_regulation (loss) of dopamine transporter associated with dopamine
10) Confidence 0.56 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.30
Blockade of dopamine transporter and tyrosine hydroxylase activity loss by [D-Ala(2), D-Leu(5)]enkephalin in methamphetamine-treated CD-1 mice.
Negative_regulation (loss) of dopamine transporter associated with dopamine and enkephalin
11) Confidence 0.56 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.43
Furthermore, pharmacologic studies have shown that significant DA depletion may occur after administration of DAT inhibitors, particularly after chronic drug treatment [13].
Negative_regulation (inhibitors) of DAT associated with dopamine
12) Confidence 0.54 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.09 Pain Relevance 0.80
These results demonstrate that the reduction of DAT activity and elevated dopaminergic tone does not abolish cocaine's rewarding effect in mice.
Negative_regulation (reduction) of DAT associated with cocaine
13) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.54
It is not clear whether cocaine inhibition of SERT or NET enhances or dampens locomotor stimulation in wild type mice where DAT is also inhibited.
Negative_regulation (inhibited) of DAT associated with cocaine
14) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.62
Methylphenidate, the primary stimulant used in pharmacological treatment of ADHD, was shown by PET imaging to block the dopamine transporter [44].
Negative_regulation (block) of dopamine transporter associated with dopamine, attention deficit hyperactivity disorder and imagery
15) Confidence 0.49 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.68 Pain Relevance 0.26
Furthermore, antidepressant treatment corrected the increased striatal D1 and D2 receptors and decreased dopamine transporter levels in the transgenic mice.
Negative_regulation (decreased) of dopamine transporter associated with targeted disruption, dopamine and antidepressant
16) Confidence 0.47 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226678 Disease Relevance 0.56 Pain Relevance 0.74
Tamoxifen at 50 microg reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mRNA levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mRNA levels.
Negative_regulation (decrease) of dopamine transporter in substantia nigra associated with dopamine and substantia nigra
17) Confidence 0.44 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17825264 Disease Relevance 0.24 Pain Relevance 0.58
Therefore, the lack of reward to cocaine observed in DAT-CI mice is unlikely to have resulted from the reduced DAT activity but instead is likely due to the inability of cocaine to block the mutated DAT and increase extracellular dopamine.
Negative_regulation (reduced) of DAT associated with dopamine and cocaine
18) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1914080 Disease Relevance 0.06 Pain Relevance 0.62
In contrast, in homozygous DAT-KO mice DAT is completely lacking.
Negative_regulation (lacking) of DAT
19) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
Therefore, the lack of cocaine reward and locomotor stimulation in DAT-CI mice is unlikely due to reduced DAT activity or the resulting hyperdopaminergic tone, but due to the inability of cocaine to inhibit the modified DAT.
Negative_regulation (reduced) of DAT associated with cocaine
20) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.08 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox