INT81047

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Context Info
Confidence 0.36
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.37
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70)
nucleus (SNRNP70)
Anatomy Link Frequency
dendritic cells 1
skin 1
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 112 96.56 Very High Very High Very High
Catechol-O-methyltransferase 35 85.92 High High
Bioavailability 1 82.28 Quite High
Pain 28 77.44 Quite High
Fibrositis 40 75.36 Quite High
agonist 3 74.56 Quite High
local anesthetic 1 67.40 Quite High
rheumatoid arthritis 42 63.76 Quite High
Lasting pain 2 58.88 Quite High
cINOD 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 51 99.70 Very High Very High Very High
Dengue 57 98.80 Very High Very High Very High
Frailty 65 97.56 Very High Very High Very High
Osteoarthritis 114 96.56 Very High Very High Very High
Increased Venous Pressure Under Development 18 96.16 Very High Very High Very High
Disease 84 94.88 High High
Communicable Diseases 2 93.68 High High
Myocardial Infarction 8 90.16 High High
Fatigue 3 78.04 Quite High
Pain 28 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 1 shows the 3D structure of TP53 in the presence and absence of a DA-SNP (SNP rs28934571), as well as the poor alignment of these structures due to the presence of the SNP.
Negative_regulation (absence) of DA-SNP
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0.28 Pain Relevance 0
Figure 1 shows the 3D structure of TP53 in the presence and absence of a DA-SNP (SNP rs28934571), as well as the poor alignment of these structures due to the presence of the SNP.
Negative_regulation (absence) of SNP rs28934571
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0.28 Pain Relevance 0
At an average density of 1.4 SNPs/kb in noncoding nonrepetitive regions of the human genome, the SNP density at a brick CH site was significantly lower at all levels of conservation (1.4-, 2.0-, 2.8-, and 4.0-fold decrease at levels 4–7, respectively; P value of any of these observations assessed using binomial distribution is less than 10?
Negative_regulation (decrease) of SNP density
3) Confidence 0.24 Published 2010 Journal Molecular Biology and Evolution Section Body Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0
In habitual young smokers, the ACh- and SNP- induced palmar skin responses were reduced, which agrees with our data.
Negative_regulation (reduced) of SNP in skin associated with nicotine addiction
4) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.82 Pain Relevance 0.10
Therefore, the signal-to-noise ratio has to be optimized by reducing the SNP list to feed into the classification model.
Negative_regulation (reducing) of SNP
5) Confidence 0.05 Published 2007 Journal BMC Proc Section Body Doc Link PMC2367463 Disease Relevance 0.25 Pain Relevance 0.03
The C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (?
Negative_regulation (polymorphism) of SNP in dendritic cells associated with dengue
6) Confidence 0.04 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 0.56 Pain Relevance 0
The National Center for Biotechnology Information (Bethesda, MD, USA) SNP database was used to assign SNP numbers.


Negative_regulation (numbers) of SNP
7) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212567 Disease Relevance 0.41 Pain Relevance 0.30
According to SNPSpD, the effective number of independent SNP loci was 23.9 thus the experiment-wide significance threshold 0.0021 was required to keep the type I error rate at 5%.
Negative_regulation (number) of SNP
8) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.68 Pain Relevance 0.27
Exposure to TNFalpha resulted in a time- and concentration-dependent HUVEC apoptosis, an effect that was prevented by pretreating the cells with NCX-4016, NO-naproxen, NO-flurbiprofen, SNP or Z-VAD.FMK, a pan-caspase inhibitor.
Negative_regulation (inhibitor) of SNP
9) Confidence 0.01 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10102977 Disease Relevance 0 Pain Relevance 0
groups (Fig. 6) found in the present study show clear evidence that treatment with Bisoprolol brings an increase in endothelial responsiveness in frequency interval VI: the ACh/SNP differentiation in absolute and normalized spectral amplitude for untreated CHF patients is statistically insignificant (6b and 6e), whereas for the CHF-?
Negative_regulation (differentiation) of SNP associated with frailty
10) Confidence 0.01 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 1.08 Pain Relevance 0.04

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