INT8106

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 18.65
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
Anatomy Link Frequency
blood 3
urine 2
bile duct 1
biliary tract 1
brain 1
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 14 99.88 Very High Very High Very High
anesthesia 33 99.68 Very High Very High Very High
abdominal pain 6 99.34 Very High Very High Very High
Etanercept 2 98.12 Very High Very High Very High
Glutamate 8 96.60 Very High Very High Very High
Paracetamol 16 96.56 Very High Very High Very High
spinal inflammation 1 95.52 Very High Very High Very High
depression 1 92.88 High High
Chronic pancreatitis 5 92.36 High High
backache 3 92.00 High High
Disease Link Frequency Relevance Heat
Pancreatitis 11 100.00 Very High Very High Very High
Exfoliation Syndrome 207 99.88 Very High Very High Very High
Liver Disease 6 99.84 Very High Very High Very High
Hepatomegaly 2 99.78 Very High Very High Very High
Alcohol Addiction 5 99.64 Very High Very High Very High
Disease 60 99.34 Very High Very High Very High
Abdominal Pain 6 99.34 Very High Very High Very High
Neuropathy 68 99.28 Very High Very High Very High
Autism 296 99.12 Very High Very High Very High
Disorder Of Lipid Metabolism 61 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purified cells were tested for endothelial characteristics, such as expression of endothelial markers, F-VIII, carbonic anhydrase IV and uptake of acetylated low density lipoprotein (AcLDL), indicating their endothelial origin and expression of gamma-glutamyl transpeptidase, indicating the brain origin (27).
Gene_expression (expression) of gamma-glutamyl transpeptidase in brain
1) Confidence 0.75 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.52 Pain Relevance 0
Treatment was interrupted for one dalcetrapib participant due to increased (>3 × ULN) levels of alkaline phosphatase (ALP), ALT, and gamma-glutamyl transferase (GGT) on Day 19.
Gene_expression (levels) of GGT
2) Confidence 0.75 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.58 Pain Relevance 0
Serum biochemical analyses were done for alanine transaminase (ALT), aspartate transaminase (AST), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), bilirubin (direct (DB), indirect (IB) and total (TB)), urea, creatinine, calcium and cholesterol.
Spec (analyses) Gene_expression (done) of GGT
3) Confidence 0.65 Published 2010 Journal Acta Vet Scand Section Body Doc Link PMC3022551 Disease Relevance 0.35 Pain Relevance 0.10
We drew femoral venous blood periodically for measurements of HCP, PCP and the following clinical serum and blood analytes: fructosamine, urea, creatinine, electrolytes (potassium, sodium and chloride), total protein and albumin, total bilirubin, alkaline phosphatase, alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), triglycerides, total and HDL cholesterol.


Gene_expression (measurements) of gamma-glutamyltransferase in blood associated with disorder of lipid metabolism
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249706 Disease Relevance 0.65 Pain Relevance 0
We drew femoral venous blood periodically for measurements of HCP, PCP and the following clinical serum and blood analytes: fructosamine, urea, creatinine, electrolytes (potassium, sodium and chloride), total protein and albumin, total bilirubin, alkaline phosphatase, alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), triglycerides, total and HDL cholesterol.


Gene_expression (measurements) of GGT in blood associated with disorder of lipid metabolism
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249706 Disease Relevance 0.65 Pain Relevance 0
In summary, for these three SNPs, the GGT haplotype was overrepresented by 66% and constituted a major risk haplotype for XFS while the GAC haplotype was underrepresented by 83% and had the lowest associated risk in XFS patients.
Gene_expression (overrepresented) of GGT associated with exfoliation syndrome
6) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.71 Pain Relevance 0
When the three haplotypes of GGT, GAC, and TGC were compared individually to non-associated haplotypes of GGC or TGT, the estimated odds ratios of 1.38 (p=0.152) or 1.98 (p=0.240), 0.15 (p=3.31x10?
Gene_expression (haplotypes) of GGT
7) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.39 Pain Relevance 0
When we tabulated the combined effect of these three SNPs on XFS, the GGT haplotype was significantly overrepresented (p=1.93x10?
Gene_expression (haplotype) of GGT associated with exfoliation syndrome
8) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.54 Pain Relevance 0
Gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin were analyzed, using a Vitros® 950 chemistry system (Ortho Clinical Diagnostics, Rochester, NY, USA).


Spec (analyzed) Gene_expression (analyzed) of GGT
9) Confidence 0.65 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2440967 Disease Relevance 0.06 Pain Relevance 0
This participant also had elevated ALP and GGT levels on Days 22, 28, 37, 55, 70, and 118, which progressively returned to normal.
Gene_expression (levels) of GGT
10) Confidence 0.65 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.49 Pain Relevance 0
Both patients had systemic progression of disease as possible explanation for the GGT elevation.
Gene_expression (elevation) of GGT associated with disease
11) Confidence 0.65 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 0.84 Pain Relevance 0.08
We found that serum GGT levels in patients with DPP were significantly higher than those in patients without polyneuropathy.
Gene_expression (levels) of GGT associated with neuropathy
12) Confidence 0.65 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 2.06 Pain Relevance 0.03
Her white blood count normalized and CRP and GGT levels fell (CRP 1.6 mg/dL, GGT 284 U/L two days before discharge).
Gene_expression (levels) of GGT in blood
13) Confidence 0.65 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2997099 Disease Relevance 0.48 Pain Relevance 0.15
-glutamyl transpeptidase levels were elevated about 1.5-fold the normal limits and that aspartate aminotransferase (AST) levels were marginally elevated.
Gene_expression (levels) of glutamyl transpeptidase
14) Confidence 0.65 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1459933 Disease Relevance 0.56 Pain Relevance 0.09
Abdominal metastases were determined by abdominal pain/tension, hepatomegaly, elevated GGT levels, serum LDH levels >500 IU, a N2 or N3 case, KPS</=70, sensitivity of 95.9, specificity of 7.1, PPV of 13.3, NPV of 92.1 and SMR of 4.1%.
Gene_expression (levels) of GGT associated with abdominal pain, hepatomegaly and metastasis
15) Confidence 0.65 Published 2007 Journal Lung Cancer Section Abstract Doc Link 17566597 Disease Relevance 1.44 Pain Relevance 0.10
In order to investigate the role of renal factors in affecting trypsinogen 1 metabolism and excretion in chronic pancreatic disease, serum immunoreactive trypsin (IRT), urinary IRT, gamma-glutamyltransferase (GGT), alpha-glucosidase (AGL) and RNase outputs and the molecular size distribution of serum and urine IRT were studied in 8 control subjects, 18 cases with pancreatic cancer, and 23 cases with chronic pancreatitis.
Gene_expression (metabolism) of GGT in urine associated with pancreatic cancer, pancreatitis and chronic pancreatitis
16) Confidence 0.65 Published 1988 Journal Pancreas Section Abstract Doc Link 3362841 Disease Relevance 0.42 Pain Relevance 0.09
Significant correlations were detected among AGL, GGT and RNase.
Gene_expression (detected) of GGT
17) Confidence 0.65 Published 1989 Journal Nephron Section Abstract Doc Link 2563574 Disease Relevance 0.98 Pain Relevance 0.16
All orthopedic treatment administered between 1970 and 1982 was analyzed in random subsamples of men 28, 38, and 48 years old being screened for serum gamma-glutamyltransferase (GGT) levels.
Gene_expression (levels) of GGT
18) Confidence 0.65 Published 1986 Journal Prev Med Section Abstract Doc Link 2872670 Disease Relevance 0.28 Pain Relevance 0.18
This study has shown that urinary excretion of APN, DPP IV, NAGA and GGT, as markers of kidney brush border and lysosomal damage, did not change after 2 g of acetaminophen taken orally. beta 2-microglobulin was a marker of acute acetaminophen nephrotoxicity in kidney disease patients and in clinically healthy adults from nephropathic families.
Gene_expression (excretion) of GGT in brush associated with nephrotoxicity, paracetamol and renal disease
19) Confidence 0.65 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.87 Pain Relevance 0.77
In order to investigate the role of renal factors in affecting trypsinogen 1 metabolism and excretion in chronic pancreatic disease, serum immunoreactive trypsin (IRT), urinary IRT, gamma-glutamyltransferase (GGT), alpha-glucosidase (AGL) and RNase outputs and the molecular size distribution of serum and urine IRT were studied in 8 control subjects, 18 cases with pancreatic cancer, and 23 cases with chronic pancreatitis.
Gene_expression (disease) of GGT in urine associated with pancreatic cancer, pancreatitis and chronic pancreatitis
20) Confidence 0.65 Published 1988 Journal Pancreas Section Abstract Doc Link 3362841 Disease Relevance 0.42 Pain Relevance 0.09

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