INT81075

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.39
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 4
muscle 1
Atp9b (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 8 98.56 Very High Very High Very High
aspirin 5 98.46 Very High Very High Very High
anakinra 4 78.16 Quite High
antagonist 14 72.16 Quite High
Percutaneous transluminal coronary angioplasty 9 63.92 Quite High
Inflammation 35 50.00 Quite Low
rheumatoid arthritis 6 9.44 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 45 99.68 Very High Very High Very High
Cv General 3 Under Development 7 98.56 Very High Very High Very High
Myocardial Infarction 14 97.76 Very High Very High Very High
Coronary Artery Disease 10 92.76 High High
Hemorrhage 9 90.44 High High
Cardiovascular Disease 3 63.32 Quite High
Sprains And Strains 4 62.80 Quite High
Thrombosis 5 56.16 Quite High
INFLAMMATION 38 50.00 Quite Low
Arthritis 4 44.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A chimeric (mouse and human) monoclonal antibody (c7E3 Fab) has been developed, which is a specific inhibitor of the platelet glycoprotein IIb/IIIa receptor and prevents platelet-to-platelet aggregation.
Negative_regulation (inhibitor) of IIb in platelet
1) Confidence 0.57 Published 1994 Journal J Invasive Cardiol Section Abstract Doc Link 10155090 Disease Relevance 0.12 Pain Relevance 0.10
All patients will receive standardised additional treatments according to best practice including aspirin, clopidogrel, heparin (intravenous or low-molecular weight), a glycoprotein IIb/IIIa inhibitor and a statin.
Negative_regulation (inhibitor) of IIb associated with aspirin
2) Confidence 0.57 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.07 Pain Relevance 0.16
The role of platelet glycoprotein IIb/IIIa receptor inhibition in the acute coronary syndromes of unstable angina and acute myocardial infarction treated by percutaneous intervention or with thrombolytic therapy is an exciting new frontier in ischaemic heart disease and is currently under investigation.
Negative_regulation (inhibition) of IIb in platelet associated with acute coronary syndrome, angina, coronary artery disease and myocardial infarction
3) Confidence 0.42 Published 1998 Journal BioDrugs Section Abstract Doc Link 18020584 Disease Relevance 0.48 Pain Relevance 0.10
The study results have unequivocally demonstrated that platelet GP IIb/IIIa receptor inhibition with abciximab during coronary intervention markedly reduces the incidence of postprocedural ischaemic events.
Negative_regulation (inhibition) of IIb in platelet
4) Confidence 0.42 Published 1998 Journal BioDrugs Section Abstract Doc Link 18020584 Disease Relevance 0.12 Pain Relevance 0.03
Finally, future studies will also focus on the role of long term GP IIb/IIIa inhibition with the new generation of orally active agents.
Negative_regulation (inhibition) of IIb
5) Confidence 0.42 Published 1998 Journal BioDrugs Section Abstract Doc Link 18020584 Disease Relevance 0.41 Pain Relevance 0.08
Early and late clinical outcome following coronary angioplasty performed with platelet glycoprotein IIb/IIIa receptor inhibition: the EPIC Trial results.
Negative_regulation (inhibition) of IIb in platelet associated with aspirin
6) Confidence 0.41 Published 1994 Journal J Invasive Cardiol Section Title Doc Link 10155090 Disease Relevance 0.13 Pain Relevance 0.16
The masseter muscle of both the mi/mi and +/+ showed a very similar pattern of MyHC IIb during the postnatal development.
Negative_regulation (pattern) of IIb in muscle
7) Confidence 0.10 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.06 Pain Relevance 0

General Comments

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