INT81087

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 13.62
Pain Relevance 16.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC3) transport (ASIC3) plasma membrane (ASIC3)
cytoplasm (ASIC3)
Anatomy Link Frequency
neurons 7
sensory neurons 5
dorsal root ganglion 4
peripheral nervous system 3
spinal cord 1
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 83 100.00 Very High Very High Very High
sodium channel 37 100.00 Very High Very High Very High
dorsal root ganglion 21 100.00 Very High Very High Very High
tissue acidosis 14 100.00 Very High Very High Very High
Inflammation 75 99.98 Very High Very High Very High
Neuropeptide 17 99.92 Very High Very High Very High
Nerve growth factor 86 99.82 Very High Very High Very High
Peripheral nervous system 7 99.68 Very High Very High Very High
Root ganglion neuron 7 99.56 Very High Very High Very High
Pain 119 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 29 100.00 Very High Very High Very High
Acidosis 25 100.00 Very High Very High Very High
INFLAMMATION 76 99.98 Very High Very High Very High
Pain 145 99.32 Very High Very High Very High
Facial Pain 8 99.16 Very High Very High Very High
Nociception 24 98.60 Very High Very High Very High
Angina 1 98.40 Very High Very High Very High
Inflammatory Pain 21 97.32 Very High Very High Very High
Coronary Artery Disease 1 97.28 Very High Very High Very High
Hyperalgesia 26 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR revealed that all these cell types expressed TRPV1 (VR1), ASIC1a, and ASIC3 subunits of proton-gated ion channels.
Gene_expression (expressed) of ASIC3
1) Confidence 0.75 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14554100 Disease Relevance 0.34 Pain Relevance 0.33
We show that NHERF-1 and ASIC3 are co-expressed in dorsal root ganglion neurons.
Gene_expression (co-expressed) of ASIC3 in neurons associated with ganglion cysts and root ganglion neuron
2) Confidence 0.59 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16234233 Disease Relevance 0.28 Pain Relevance 0.37
The ASIC3 subunit is largely expressed in the peripheral nervous system, where it contributes to pain perception and to some aspects of mechanosensation.
Gene_expression (expressed) of ASIC3 in peripheral nervous system associated with mechanosensation, pain and peripheral nervous system
3) Confidence 0.59 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16234233 Disease Relevance 0.23 Pain Relevance 0.36
ASIC3 and these interacting proteins were expressed in dorsal root ganglia and spinal cord, and PSD-95 co-precipitated ASIC3 from spinal cord.
Gene_expression (expressed) of ASIC3 in spinal cord associated with spinal cord
4) Confidence 0.51 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.38
The acid-sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral nervous system.
Gene_expression (expressed) of ASIC3 in peripheral nervous system associated with peripheral nervous system and sodium channel
5) Confidence 0.51 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.33
The ASIC1b and ASIC3 subunits are specifically expressed in sensory ganglia neurons and are candidate sensors of peripheral acidosis.
Gene_expression (expressed) of ASIC3 in neurons associated with acidosis
6) Confidence 0.47 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16549075 Disease Relevance 0.35 Pain Relevance 0.37
The acid-sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral nervous system.
Gene_expression (expressed) of acid-sensing ion channel-3 in peripheral nervous system associated with peripheral nervous system and sodium channel
7) Confidence 0.44 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15317815 Disease Relevance 0 Pain Relevance 0.33
Detection of a shorter fragment of ASIC1a (461 bp) with primers HASIC3 and HASIC4, also yielded negative results even after 50 cycles (Figure 1, Lane C).
Gene_expression (Detection) of HASIC3
8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.09
Acid-sensing ion channel 3 (ASIC3), a depolarizing sodium channel gated by protons during tissue acidosis, is specifically expressed in sensory neurons.
Gene_expression (expressed) of Acid-sensing ion channel 3 in sensory neurons associated with acidosis, sodium channel and tissue acidosis
9) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.68 Pain Relevance 0.95
We previously showed that low endogenous NGF was responsible for ASIC3 basal expression and high NGF during inflammation increased ASIC3 expression parallely to the development of neuron hyperexcitability associated with hyperalgesia.
Gene_expression (expression) of ASIC3 in neuron associated with hyperalgesia, inflammation, nerve growth factor and hyperexcitability
10) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.69 Pain Relevance 1.02
NGF controls ASIC3 basal expression through constitutive activation of a trkA/phospholipase C/protein kinase C pathway, (ii). high inflammatory-like NGF induces ASIC3 overexpression through a trkA/JNK/p38MAPK pathway and a p75-dependent mechanism as a transcriptional switch, and (iii).
Gene_expression (expression) of ASIC3 associated with kinase c, inflammation and nerve growth factor
11) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.67 Pain Relevance 1.08
Acid-sensing ion channel 3 (ASIC3), a depolarizing sodium channel gated by protons during tissue acidosis, is specifically expressed in sensory neurons.
Gene_expression (expressed) of ASIC3 in sensory neurons associated with acidosis, sodium channel and tissue acidosis
12) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.67 Pain Relevance 0.95
We previously showed that low endogenous NGF was responsible for ASIC3 basal expression and high NGF during inflammation increased ASIC3 expression parallely to the development of neuron hyperexcitability associated with hyperalgesia.
Gene_expression (expression) of ASIC3 in neuron associated with hyperalgesia, inflammation, nerve growth factor and hyperexcitability
13) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.70 Pain Relevance 1.02
CIPP mRNA is found at a significant level in the same dorsal root ganglion neuronal cell population that expresses the ASIC3 subunit, i.e. mainly in the small nociceptive neurons.
Gene_expression (expresses) of ASIC3 in neurons associated with nociception, ganglion cysts and dorsal root ganglion
14) Confidence 0.35 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.48 Pain Relevance 0.29
The ASIC3 subunit is mainly expressed in dorsal root ganglion neurons.
Gene_expression (expressed) of ASIC3 in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
15) Confidence 0.35 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.38 Pain Relevance 0.32
CIPP is thus a scaffolding protein that could both enhance the surface expression of ASIC3 and bring together ASIC3 and functionally related proteins in the membrane of sensory neurons.
Gene_expression (expression) of ASIC3 in sensory neurons
16) Confidence 0.35 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.44 Pain Relevance 0.24
P2X(3), TRPV1, and ASIC3 are often co-expressed in trigeminal neurons, implying the formation of functional complexes that allow craniofacial nociceptive neurons to respond synergistically to altered ATP and pH in pain.
Gene_expression (co-expressed) of ASIC3 in neurons associated with nociception and pain
17) Confidence 0.31 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19329451 Disease Relevance 1.26 Pain Relevance 1.04
NGF controls ASIC3 basal expression through constitutive activation of a trkA/phospholipase C/protein kinase C pathway, (ii). high inflammatory-like NGF induces ASIC3 overexpression through a trkA/JNK/p38MAPK pathway and a p75-dependent mechanism as a transcriptional switch, and (iii).
Gene_expression (overexpression) of ASIC3 associated with kinase c, inflammation and nerve growth factor
18) Confidence 0.28 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.64 Pain Relevance 1.05
Co-expression of CIPP and ASIC3 in COS cells increases the maximal ASIC3 peak current density by a factor of 5 and slightly shifts the pH(0.5) for activation from pH 6.2 to pH 6.4.
Gene_expression (expression) of ASIC3
19) Confidence 0.27 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.48 Pain Relevance 0.32
Co-expression of CIPP and ASIC3 in COS cells increases the maximal ASIC3 peak current density by a factor of 5 and slightly shifts the pH(0.5) for activation from pH 6.2 to pH 6.4.
Gene_expression (-) of ASIC3
20) Confidence 0.27 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.48 Pain Relevance 0.32

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